FluidFM Nanoprinting - Print any pattern at sub-micrometer resolution - Medical / Health Care - Clinical Services

FromCytosurge AG

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FluidFM® Nanoprinting for researchers who need precise tools to manipulate, create and prototype on the nano- and microscale.

FluidFM technology with its microfluidic probes offers unprecedented versatility and control to print patterns and explore nanostructure creation. Whether you are working with protein arrays for sensing applications, chemical gradients for cell migration studies, want to understand chemical processes in femtoliter droplets, or are interested to develop the next generation of nano-fabrication processes – FluidFM will open new doors for your research.

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From femtoliter to nanoliter
Print femtoliter droplets or deposit up to nanoliter volumes.

From nm to cm
Print features as small as 300 nm and create patterns up to cm in scale.

1 to 10’000 cP viscosity
Customers have printed with inks from 1 to 10’000 cP. From water to honey.

In air and in liquid
FluidFM technology works both immersed and in ambient conditions.

Wide range of inks
Water. Buffers. Oils. Acids. Solvents. Nanoparticles. And more.

Any pattern from µm to cm at sub-micrometer resolution

Our long-range XY-stage enables precise printing of 2.5D patterns at any size from µm to cm at sub-micrometer resolution. Spots can be printed from micro- to nanoscale with the appropriate FluidFM Probe type.

With any ink

Any liquid with viscosities ranging from 1 cP to 10`000 cP (water to honey) can be pipetted into the 1 µl reservoir and dispensed through our FluidFM Probes made of silicon nitride. If needed, probes can be coated before use, eg with anti-fouling surface chemistry. Use virtually any soluble substance: DNA, RNA, proteins, nanoparticle solutions and many other.

From nl to fl. Highly reproducible.

FluidFM can deposit volumes anywhere from sub fl to nl, depending on probe type and printing parameters. Thanks to the highly reproducible FluidFM Probe geometry and the precise, pressure-controlled flow, you can expect reproducible results over many experiments. The video shows an example of ~1 nL and ~50 fL droplet printing of protein solution on a functionalized surface in air.

Print in liquid and in air.

Material can be deposited both in liquid and air environment. When printing in air, the material transfer to a surface is mainly governed by pressure and capillary forces, while in liquid pressure and diffusion are key factors.

Print next to living cells

FluidFM can operate immersed - on live cell cultures. Guide cell migration through chemical or protein printed patterns. Shower selected single cells with chemicals. Observe the effects real-time within the cell culture context, as FluidFM is fully compatible with inverted microscopes and transparent samples.

Fast preparation & intuitive software

With the FluidFM OMNIUM, the experiment preparation just takes 5 minutes, and the user-friendly software makes the process extremely easy:

Fill the reservoir of the chosen FluidFM Probe
Place probe & sample into the system
Load your printing file containing the pattern
Follow the software instructions & recommended procedures
Preview your pattern and start the printing
The system autonomously prints according to the loaded file
Instruct the system to take the required images

Choose the most adequate nozzle geometry and size

Distinct patterns in various sizes can be easily printed due to the variety of available FluidFM Probe tips and aperture sizes ranging from 300 nm to 8 µm).

FluidFM Micropipette

Higher deposition rate
2, 4 and 8 µm diameter choice
Ideal for spotting
For high material deposition rate
In liquid & air

FluidFM Nanosyringe

Controlled tip-substrate contact
Sub-micrometer lines
For high-resolution patterns
In air

FluidFM Nanopipette

Direct ink-substrate contact
Sub-micrometer lines
For high-resolution patterns
In liquid & air