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13 applications found
The new standard for quality, capacity, and speed. Deliver the best cell lines. Set your IND up for success by getting FDA-accepted monoclonality assurance in just ...
ByBruker Corporation based in Billerica, MASSACHUSETTS (USA)
Explore interaction profiles and identify off-target binding. Most drugs in common use are small organic molecules which interact functionally with proteins, either acting as ligands for receptors, inhibiting enzymes or blocking protein interactions, etc. Their activities have generally been established by specific cellular and molecular assays to determine mode of action. While frequently well tolerated, side-effects are nevertheless commonplace and can be the result of unexpected interference with unintended ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Protein arrays are exposed to enzymes to identify targets for post-translational modifications. Many key protein functions require the protein to undergo a post-translational modification (PTM), examples ranging from phosphorylations and glycosylations to histone modifications and ubiquitinations. HuProt human proteome microarrays can be used for profiling the targets of enzymes producing PTMs and have been used in studies of phosphorylation, glycosylation, sumoylation, ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
HuProt arrays provide a primary platform for screening proteins for binary interactions with the world's largest collection of human proteins immobilised on a single microarray. Over 20,000 potential interactions are assessed in a single experiment. Array screening facilitates detection of interactors with low abundance in cellular systems. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Comprehensive antibody reactivity profiling: validate specificity, identify cross-reactions. The issue of antibody cross-reactivity is one that has often been often overlooked or sidelined in the past, with typical antibody QC involving evidence of binding to the intended target, while neglecting potential cross-reactivity. In recent years, however, many examples have come to light where poor validation of antibodies has led to misleading or erroneous conclusions for assays in which they are used as reagents, due ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Restrain or divert surface floating and semi submerged debris, logs, wood, aquatic vegetation, urban waste, loose ice, etc. Prevent debris from entering waterways. Collect debris for scheduled removal at accessible areas. Divert debris away from structures when depolyed at an angle to prevailing flow. Keep intakes and screens clear. Protect equipment from ...
ByGood Innovation LLC based in Sacramento, CALIFORNIA (USA)
Identify interacting proteins for your DNA/RNA molecule of interest. Profiling of nucleic acid binding on HuProt human proteome microarrays can reveal interactions with the largest collection of individual human proteins available on a single slide. Nucleic acid-protein interactions regulate many aspects of gene expression and thus cell physiology and pathology. DNA-protein interactions occur via a range of binding motifs present in transcription factors and nuclear receptors (e.g. DNA-binding domains, zinc ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
A high incidence of thromboembolic complications leading to organ-failure, stroke, pulmonary embolism (PE) and deep vein thrombosis (DVT) have been reported in asymptomatic, symptomatic, and recovering patient groups. ...
ByAbram Scientific, Inc. based in Menlo Park, CALIFORNIA (USA)
The concept behind protein arrays is the immobilisation of sets of proteins, up to very large numbers, on solid supports, to perform miniaturised, multiplexed binding assays with a variety of potential ligands or interactants (see powerpoint presentation on right). HuProt v4 human proteome arrays as used at CPA comprise full length human proteins, many of which will retain their native conformation. HuProt arrays can be distinguished from arrays of peptides, used primarily to identify linear epitopes, or protein ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Discover autoantigens in autoimmune diseases, delineate new candidate biomarkers. Autoantibodies are present in the blood of all healthy individuals. However, when directed at high levels against protein targets in specific tissues, autoantibodies can be a major cause of autoimmune diseases. They are also important biomarkers for diagnosis of these conditions. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
Predict Health Monitoring provides online Occupational Health Screening Assessment Tools, giving insight into the health status of your work force at any one ...
ByEnigma based in Auckland, NEW ZEALAND
Rapid and efficient screening tools are an essential step in the global fight against COVID-19 and key to ensuring a safe return to daily life and social interactions. Today, nucleotide-based testing (RT-PCR) is the gold standard for diagnosing the disease. But, while sensitive, these tests are limited by long turnaround times, high costs and a typically invasive and uncomfortable nature of ...
ByAbionic SA based in Epalinges, SWITZERLAND
The wide use of water in cooling processes – but also processing – requires high precision in its filtration and separation. Installing low quality or inadequate parameters screens may lead to damage of whole devices or even to the temporary stoppage of the entire process. How to minimise this risk? Select individually designed and precisely made ...
ByProgress Eco S. A. based in Tuczepy, POLAND