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Liposomes - Hollow Nanospheres for Brain Drug Delivery - Medical / Health Care
The trespassing of the blood brain barrier is a challenge for the treatment of central nervous diseases such as Alzheimer, Parkinson, stroke, or cancer (glioma). The endothelium shows tight junctions and specialized transporters which limits the bioavailability of drugs in the central nervous system.
The most invasive way of reaching the brain is directly injecting the drug in the brain through a catheter, which has many risks associated. Encapsulation of the drug in liposomes allow a non-invasive way to penetrate this barrier, since they are able to circulate, reach and permeate through it with adequate targeting strategies. Currently this is already being exploited and several liposomed central nervous system pharmaceuticals are in clinical trials or already marketed for the treatment of meningitis, pediatric brain tumors and glioblastoma with great success.