Ocular Implants Technology for Postoperative Bacterial Endophthalmitis - Medical / Health Care - Clinical Services
Postoperative bacterial endophthalmitis is a rare but devastating complication that can occur following ocular surgery.1 Without proper intervention, endophthalmitis can cause irreversible damage to structures within the retina resulting in a loss of vision.2 This inflammatory condition affecting the intraocular cavities is typically caused by a bacterial or fungal infection, with the most common causative agents including coagulase-negative staphylococci, Staphylococcus aureus, streptococci and other Gram-positive cocci.
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Patients are often prescribed topical prophylaxis such as antibiotic, steroids and NSAID drops as part of post-surgical care. Surgeons also treat patients with intracameral injections of antibiotics; however, these are not approved for the treatment of endophthalmitis and are only used off-label.5 The success of topical therapies is inconsistent due to poor compliance with dosing or drop competence, particularly in elderly patients with comorbidities.
There is a need for a safe biodegradable solution that effectively prevents and treats ocular infections following cataract surgery, is well tolerated by patients, and provides a constant drug dose with a predictable degradation profile.