Johnson Articles
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Garwood Medical Devices, LLC named as an Awardee in the Innovations for Vets QuickFire Challenge Innovation
Garwood Medical Devices, LLC has been selected as an awardee of the Innovations for Vets Quickfire Challenge launched by Johnson & Johnson Innovation – JLABS with the Johnson & Johnson Office of Military and Veterans Affairs. The intention behind this challenge was to help advance innovation that could benefit the military community. As a company named after veterans, Garwood ...
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Cancer Care Center of York County Sanford, Maine - Case Study
Key Parameters Type of Facility – Existing Build (EB) Function – Healthcare Area – 1-story Oncology and Patient Care Building Project Completed – 2007 Challenge: Clean air is important but it is extremely important for oncology patients. When the facility opened in 2006, the center’s proximity to a nearby rubber plant resulted in odors frequently being ...
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Prominent Names in RNA Delivery Discuss What’s Around the Corner
Oxford Global kicked off another exciting discussion group all about RNA therapeutics and emerging technologies for their delivery. Those attending were experts from the leading authorities in the field. Leading the conversation was Susan Rosenbaum, Founder, Chairman, and CEO of Lauren Sciences, a company that has been the recipient of twelve foundation grant awards and won first prize for Global ...
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New Method to Produce Ring-Opening Metathesis Polymers with Facile Degradability
A team of chemists at MIT has formulated a method to produce polymers that can disintegrate more readily in the body as well as in the environment. A new type of polymer designed by MIT chemists incorporates a special monomer (yellow) that helps the polymers to break down more easily under certain conditions. (Image credit: Demin Liu) A chemical reaction known as ring-opening metathesis ...
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J&J’s Auris Acquisition Featured in Forbes Article
Forbes recently featured Auris in an article about Johnson & Johnson's $3.5 billion all-cash acquisition of the company. In the deal, Auris is also eligible to receive up to $2.35 billion in additional milestone payments. This deal will boost J&J's plan to expand its robotics program. Auris was joined in 2007 by one of the pioneers of the robotic surgery, Dr. Fred Moll and since then ...
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Human VP8* mAbs neutralize rotavirus selectively in human intestinal epithelial cells
Abstract We previously generated 32 rotavirus-specific (RV-specific) recombinant monoclonal antibodies (mAbs) derived from B cells isolated from human intestinal resections. Twenty-four of these mAbs were specific for the VP8* fragment of RV VP4, and most (20 of 24) were non-neutralizing when tested in the conventional MA104 cell–based assay. We reexamined the ability of these mAbs to ...
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Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis
Abstract Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin α5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site, S651. Active PDE then hydrolyzes antiinflammatory cAMP to ...
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Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming
A population of NK cells expressing the activating receptor NKG2C and the maturation marker CD57 expands in response to human CMV (HCMV) infection. CD3–CD56dimCD57+NKG2C+ NK cells are similar to CD8+ memory T cells with rapid and robust effector function upon restimulation, persistence, and epigenetic remodeling of the IFNG locus. Chronic antigen stimulation drives CD8+ memory T cell ...
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Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Abstract Electronic nicotine delivery systems (ENDS) or e-cigarettes have emerged as a popular recreational tool among adolescents and adults. Although the use of ENDS is often promoted as a safer alternative to conventional cigarettes, few comprehensive studies have assessed the long-term effects of vaporized nicotine and its associated solvents, propylene glycol (PG) and vegetable glycerin ...
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Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease. A maladaptive epithelium due to chronic injury is a prominent feature and contributor to pathogenic cellular communication in IPF. Recent data highlight the concept of a “reprogrammed” lung epithelium as critical in the development of lung fibrosis. Extracellular vesicles (EVs) are potent mediators of cellular ...
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Degradation of splicing factor SRSF3 contributes to progressive liver disease
Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), ...
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
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Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including Parkinson’s disease (PD). Despite widespread clinical use, its therapeutic mechanisms are unknown. Here, we developed a mouse model of subthalamic nucleus (STN) DBS for PD, to permit investigation using cell type–specific tools available in mice. We found that electrical STN DBS relieved ...
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UVision360, Inc. – Luminelle DTx Hysteroscopy System
Allison London Brown, CEO of UVision360, Inc. in North Carolina, discusses the Luminelle DTx Hysteroscopy System. Traditionally, these procedures are conducted in a hospital or ambulatory setting. But the Luminelle system is compact and designed to be used in the doctor’s office, and the company is expected to file an application with the FDA that will allow doctors to conduct the first ...
By LUMINELLE
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Huron Perth Healthcare Alliance – Stratford Hospital, Stratford, Ontario, CANADA
A FLU-ACE waste heat recovery solution at the Stratford General Hospital site of the Huron Perth Healthcare Alliance was supplied to Johnson Controls, Inc. by Thermal Energy as part of its major energy reduction project at the Alliance’s four hospitals. The 10-metre tall FLU-ACE system which sits mostly inside the hospital’s boiler room facility and captures the waste heat and flue gases from ...
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Pediatric benefits fact sheet
Because children have more delicate immune systems than adults, water contaminants pose a more serious threat to the young. Drinking only the highest quality water is one way that parents can contribute to keeping their children healthy, even before they are born. Pregnant women need to be especially careful of the water they drink. Certain levels of some water contaminants such as lead, nitrate ...
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Robotics startup Vicarious files pre-submission with FDA, fresh from $220M SPAC raise
Vicarious Surgical has filed a pre-submission with the FDA, marking the start of a regulatory process it hopes will lead to a 510(k) application by late 2023. Dive Brief: Vicarious Surgical has filed a pre-submission with the FDA, marking the start of a regulatory process it hopes will lead to a 510(k) application by late 2023. The filing, which Vicarious disclosed in its first quarterly ...
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Why Digital Therapeutics Contribute to Mental Health Access & Equity
Lack of providers, long wait times for appointments, costs and other challenges can make it tough to access mental health care. Some of the communities most affected by mental health struggles are at the highest risk for not receiving care. Overcoming care obstacles Negative attitudes toward people living with mental health conditions are common in the U.S. One study showed that 63% of Black ...
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John Glenn, NASA Langley, and Hampton, VA
As we say good-bye to John Glenn, it is a good time for Teledyne Hastings to recall with pride our company’s and our city’s connection to this great American hero. Now, many people know that John Glenn was the first American to orbit the earth. But most people don’t know that the original seven Mercury astronauts, including John Glenn, received their original spaceflight ...
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Jesse Brown VA Medical Center - 3.4 MW CHP Application - Case Study
Quick Facts LOCATION: Chicago, Illinois PRIME MOVER: (1) Solar Centaur 40TM Natural Gas Turbine GENERATING CAPACITY: 3,419 kW HEAT RECOVERY EQUIPMENT: (1) Kentube Heat Recovery Steam Generator 50,000/15,000 lbs/hr (fired/unfired) (1) 800 ton Absorption Chiller HEAT RECOVERY APPLICATION: Building Heat, Absorption Cooling IMPLEMENTATION COST: $12.5 million (energy center & CHP system) TOTAL ...
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