M. Articles
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Cadmium Accumulation and Antioxidative Responses in the Sesbania drummondii Callus
Abstract The effect of cadmium (Cd) on growth, accumulation, and antioxidative response was studied in Sesbania drummondii callus, cultivated on different concentrations of Cd (0–250 μM) for four weeks. Callus growth was comparable to that of the control for concentrations up to 50 μM Cd; however, concentrations higher than 50 μM affected growth. A concentration of 100 μM Cd ...
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Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants
Abstract Detailed IgE-binding epitope analysis is a key requirement for the understanding and development of diagnostic and therapeutic agents to address food allergies. An IgE-specific linear peptide microarray with random phage peptide display for the high-resolution mapping of IgE-binding epitopes of the major soybean allergen Gly m 4, which is a homologue to the birch pollen allergen Bet v ...
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EU GMP Annex 1 FAQs - Air Speed Strategies for Unidirectional Flows
The following frequently asked questions arose at a presentation given by PMS Senior GMP Scientist, Mark Hallworth, on the 6th of December on the topic of EU GMP Annex 1 Air Speed Strategies for Unidirectional Flows. Why do manufacturers like ESCO, ThermoFisher Scientific, and Nuaire adopt different air speed values for 2A2 and 2B2 biological safety cabinets compared to the suggested range of ...
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Rock cut on the A5 at Glyn Bends, North Wales, UK
This paper discusses the challenges involved in the upgrading of the A5 London to Holyhead road through Glyn Bends, an area of natural beauty adjacent to the Snowdonia National Park in North Wales. At the location where it passed through a steep gorge in the Ordovician metasiltstones, part of the original road was supported on 200 year old, 10 m high retaining walls. The metasiltstones contain ...
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Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema
Abstract Purpose: The purpose of this study was to describe a novel device that may serve as an alternative to Descemet membrane endothelial keratoplasty (DMEK) for the treatment of chronic corneal edema. Methods: The EndoArt (EyeYon Medical, Israel) is a flexible, 50-μm thin artificial endothelial layer that matches the cornea’s posterior curvature and functions as a fluid barrier ...
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Morphology and geometry of CO2-laser machined PMMA microchannels: influence of molecular weight and number of cut passes
Laser micromachining has been utilised for fabricating channels in polymeric microfluidic devices. The present work focuses on a study of the influence of polymer molecular weight (Mw) on the depth and width of microchannels in polymethyl methacrylate (PMMA) that are machined using a CO2 laser. PMMA of four molecular weights, namely, 96.7 kDa, 120 kDa, 350 kDa and 996 kDa were used. The laser cut ...
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The effect of Mentha spicata Labiatae on uterine tissue in rats
The plant Mentha spicata, or peppermint, is commonly used in the treatment of loss of appetite, common cold, bronchitis, sinusitis, fever, nausea and vomiting, and indigestion as a herbal agent. In this study, we aimed to investigate the biochemical and histological effects of M. spicata Labiatae, growing on the Anamas high plateau of Yenisarbademli town, on rat uterine tissue. Twenty female ...
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DNA-protein crosslinks induced by formaldehyde and its repair process
KCL-SDS assay was used to explore DNA-Protein Crosslinks (DPC) effect induced by formaldehyde (FA) and the repair. Gaseous FA could cause DPC at concentrations as 1.0 mg m−3 and 3.0 mg m−3 (p Keywords: formaldehyde, in vivo, in vitro, DPC, DNA-protein crosslinks, repair, DNA, ...
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Survival of
Mycobacterium tuberculosis andMycobacterium bovis in human urineTuberculosis is a zoonotic disease that mainly causes respiratory infection. However, it can also infect other organs such as the kidneys and bladder, which can lead to high counts of the organisms in the urine. Introducing urine diversion systems and reuse of the urine in agriculture may introduce new transmission routes for infection, increasing the risk of spread. This study evaluated the ...
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Continuous, Centralized Monitoring Drives O&M Optimization
In a survey conducted by Wind Energy Update this year, 80% of wind turbine owners indicated they take either a predictive or preventative approach to maintenance. Furthermore, 77% indicated that they deploy Condition Monitoring Systems (CMS). “If you can leverage data to increase plant performance by even 1%, you are looking at significant impacts to your revenue”, EDF’s ...
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The disappearance of dedicated biotechnology firms in Canada
The present paper has the objective of understanding the disappearance of biotechnology firms. To accomplish this objective, a sample was built from 552 firms operating in Canada between 1996 and 2010. The results reveal that disappearance is not only due to filing for bankruptcy, but also due to change in firms' names, as well as mergers and acquisitions (M&A). Statistical tests further show ...
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Exploring the Potential Applications of Fluorescent Microspheres
Microspheres are small spherical entities formed by dispersing or adsorbing drugs in a polymer matrix. The particle size is typically between 1 μm and 250 μm, and the largest can reach more than 800 μm. Microsphere technology is at the intersection of cutting-edge disciplines such as materials science, polymer technology, medical technology, and microelectronics. Once injected into the ...
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The survival of mycobacteria in pure human urine
Mycobacterial pathogens can be excreted in human urine by some infected individuals. High numbers of pathogenic mycobacteria in the urine could represent a new transmission route for mycobacterial infections if the urine is used for crop fertilization. In this study, the survival of spiked Mycobacterium aurum and M. fortuitum as fast-growing mycobacteria and M. avium and M. bovis as ...
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Anaphase-promoting complex/cyclosome-cdh1-mediated proteolysis of the forkhead box m1 transcription factor is critical for regulated entry into s phase
The forkhead box M1 (FoxM1) transcription factor is overexpressed in many cancers, and in mouse models it is required for tumor progression. FoxM1 activates expression of the cell cycle genes required for both S and M phase progression. Here we demonstrate that FoxM1 is degraded in late mitosis and early G1 phase by the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. FoxM1 ...
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Advice for EU GMP 5 μm Particle Limits
Abstract The EU GMP Annex 1 Guide requires continuous particle monitoring in Grade A and immediate Grade B areas using an in situ particle counting system, such as the Airnet II or IsoAir 310P. This is because the risk of contamination of finished product is very high and the greatest risk, the operator, is in close proximity. The operator is not only the greatest risk posed to product but also ...
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Study on the mutual interactions between the parameters of a CANON system and its coping strategy when operating at room temperature (15 to 25 °C) using response surface methodology
The coping strategy of a CANON (completely autotrophic nitrogen removal over nitrite) reactor working at room temperature was investigated using response surface methodology. The total nitrogen (TN) removal efficiency was taken as a dependent variable. The temperature (X), dissolved oxygen (DO) concentration (Y), and influent nitrogen loading rate (Z) were taken as independent variables. ...
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Spatial multi-omics sequencing for fixed tissue via DBiT-seq
Highlights Simultaneous transcriptomic and proteomic analysis on fixed tissue slides 10- and 25-μm spot size for varying resolution and near-single-cell analysis DBiT-seq can be conducted with common laboratory equipment and reagents DBiT-seq produces high-quality RNA sequencing data with high spatial resolution (10 μm) Summary This protocol describes the use of the ...
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Ultrasonic characterization of proteins and blood cells
Ultrasound changes its intensity and speed when propagating through a liquid or a suspension containing particles. In addition it generates a weak electric signal by altering the motion of ions and charged particles. Hence acoustic and electroacoustic measurements provide information about the properties of suspended particles and molecules. Here we present both acoustic and electroacoustic ...
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An analysis of the correlation between the non-cancer morbidity of children and the internal dose of 137Cs
This paper sets out to accomplish the following: (i) to define the relationship of child morbidity of the digestive system with the low radiation internal dose, taking into account the environmental landscape-geochemical conditions of residence territory and the age peculiarities of children, (ii) to select groups composed of children 0-14 years old and who live in analogical environmental and ...
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EluNIR DES in a Challenging Case - Case Study
Background: This paper describes a challenging case of implantation of the EluNIR™ Ridaforolimus eluting elastomeric stent (Medinol Ltd.). This complex case involved a patient with a flow-limiting lesion in a native coronary artery post bypass surgery. The new EluNIR stent system includes a stent with a low metal footprint that comprises struts of variable width: ultra-narrow struts ...
By Medinol
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