ADCs Customized Linkers

Antibody Drug Conjugates (ADCs) use targeting ability of monoclonal antibodies to deliver potent cytototoxic payloads to their intended target. The linker encompasses a conjugating functionality suitable for attachment to the antibody, a spacer unit that typically incorporates a hydrophilic element and a trigger which releases the potent cytototoxic warhead. The properties that an optimal linker needs to fulfill are manifold: for efficient delivery of the payload to the tumor, the linker has to be stable in circulation, but at the site of the tumor, it has to be cleaved to release the active payload catabolite from the antibody. Depending on the target biology of the antibody, the linker may be cleaved either extracellularly in the tumor microenvironment or intracellularly after internalization and trafficking to the lysosomes, and thus the linker chemistry needs to be designed accordingly.

ALL Chemistry Inc. offers linkers for solid-phase chemistry, ADC linkers and various other linker molecules, with a wide variety of founctional groups, as well as custom synthesized linkers to suit your needs. ALL Chemistry Inc. understands the conflicting requirements of ADC design, provides stability in systemic circulation but efficient payload release once the ADC reaches its intended target, which is crucial to effective linker development. ALL Chemistry Inc. have approached ADC linker design in a variety of different ways, with increasingly elegant solutions continuing to be reported as understanding of the intricate design complexities increases. We focuse on the synthetic approaches used in ADC linkers, and the impact of linker design on antibody conjugation, ADC pharmacokinetics and payload release.