Airway Inflammation Articles & Analysis
11 articles found
High levels of nitric oxide can indicate airway inflammation, commonly found in allergic asthma. Asthma is a common respiratory condition that affects around 5.4 million people in the UK , sadly high numbers of people are dying each year from asthma and it is thought a high percentage of these deaths are avoidable. ...
This is normal in exhaled breath as a part of the respiratory process but is raised in the presence of eosinophilic airway inflammation, which is present in the majority of people with uncontrolled asthma symptoms. ...
This review brings significant changes to asthma care approaches, including applying fractional exhaled nitric oxide (FeNO) testing- an objective airway inflammation test for aiding in asthma diagnosis and management. ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
It is a combination of variable symptoms, and you may find that over weeks or months, you experience a difference in symptoms. The underlying problem is the airways, the airways can either have hyperresponsiveness, which is an increased sensitivity of the airways or inflammation. ...
Methods of measuring FeNO Fractional exhaled nitric oxide (FeNO) measurement plays a crucial role in the diagnosis and management of airway inflammation. FeNO testing is recommended by the National Institute for Health and Care Excellence (NICE) to help diagnose asthma1, with the NObreath® device one of three devices recommended by NICE1. ...
FeNO Testing in Asthma Care Although airway eosinophilic inflammation is a key characteristic of asthma, there are few methods available to measure it. ...
Despite advancements in treatment, many patients still struggle with symptom control and recurrent attacks. While inflammation has been the focal point of asthma research, a recent study sheds light on a mechanical aspect that could refine our understanding and treatment of the condition. ...
Inflammatory effectors are key cytokines driving major clinical symptoms, like INF-γ inducing fever and hematopoiesis, TNF-α causing fever and depression, and IL-6 contributing to fever, acute kidney injury, and NK cell dysfunction. Inflammation initiation factors involve virus recognition by macrophage pattern receptors, triggering inflammasome assembly and the ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
Recently, in a study published in Cell Reports entitled "GM-CSF production by non-classical monocytes antagonistic controls LPS-driven functions in allergic inflammation," scientists from the University of Alabama and other institutions found through the study that the key to LPS promoting or preventing the body's anaphylaxis lies in the allergen itself. Further understanding ...