Antigen Affinity Articles & Analysis: Older
4 articles found
They have the advantages of small size, high stability, and good penetration, and therefore have a wide range of application prospects in the fields of clinical treatment, diagnostic reagent development, etc.Characteristics of NanobodiesThe size of nanobodies usually ranges between 10-15kDa, which is only 1/10 of the size of regular antibodies. Their unique antigen-binding ...
Smaller volume Nbs can achieve higher tissue penetration and stronger cell killing in vivo.Antigen recognition ability: Among all complementarity determining regions, CDR3 accounts for 60-80% of the antigen recognition specificity. The CDR3 loop is long and extended. This characteristic gives VHH better antigen recognition specificity and ...
Antibody Backbone: The Starting Point for ADC Design l Selection of antigen specificity Since the mechanism of ADCs begins with the binding of target cells, the antibody should have high specificity for the target antigen. ...
Here, using a genetic timestamping system in mice, we show that persistent PCs accrue in bone marrow at an approximately constant rate of one cell per hour over a period spanning several weeks after a single immunization with a model antigen. Affinity-based selection was evident in persisting PCs, reflecting a relative and dynamic rather than absolute ...