autoimmune Articles
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Experimental confirmation of the `protein traffic hypothesis` by routine diagnostic tests
The 'protein traffic hypothesis' suggests that the inflammation associated with autoimmune disease, trauma and disturbances of blood circulation is the result of misguided protein trafficking. The hypothesis divides the antigen spectrum into an intracellular component and an extracellular component. While the intracellular component is recognised by MHC class-I molecules and is presented to CD8 ...
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Harnessing the utility of autoantibodies to overcome challenges associated with clinical development in Systemic Lupus Erythematosus (SLE)
Overcoming issues of heterogeneity in disease classification and enabling new approaches to successful drug development. SLE is an autoimmune disease with a wide range of clinical manifestations. It affects approximately 5 million people worldwide and its prevalence varies in different geographies. SLE accounts for around 70% of all cases of lupus, other forms being cutaneous lupus, ...
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Overview Of SFA Therapeutics
SFA Therapeutics’ CEO Dr Ira Spector presents an overview of the company and its platform technology SFA Overview Presentation on YouTube Introduction to SFA Liver Disease and Oncology Programs. SFA Oncology More information here We received US Patent 10,143,669B2; to prevent Hepatitis B progression to HCC, a liver cancer that affects 400 million patients and causes 1 million cancer ...
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The power of autoantibodies to enhance clinical development success in Systemic Sclerosis (SSc)
An unmet need for disease-modifying therapy persists for patients with Systemic Sclerosis SSc is an autoimmune disease characterised by widespread vascular injury, progressive fibrosis of the skin and internal organs, and a specific pattern of autoantibodies. The clinical manifestations of SSc are highly heterogenous with significant internal organ manifestations causing a greater mortality ...
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Potentials of transforming growth factors alpha and beta-1 in predicting the clinical outcome of bladder carcinoma
The 'protein traffic hypothesis' suggests that the inflammation associated with autoimmune disease, trauma and disturbances of blood circulation is the result of misguided protein trafficking. The hypothesis divides the antigen spectrum into an intracellular component and an extracellular component. While the intracellular component is recognised by MHC class-I molecules and is presented to CD8 ...
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OCD: an "autoimmune disease"
Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a multifactorial disorder with an interplay of biological, psychological, and external factors, and ...
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Survivin as a biological biomarker for diagnosis and therapy
Survivin (SVN) is a member of the inhibitor of apoptosis (IAP) protein family that promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated with autoimmune disease, hyperplasia, and tumors and can be used as a biomarker in these diseases. SVN is widely recognized as a tumor-associated antigen (TAA) and has become an important target for cancer diagnosis and ...
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Saving Us from Ourselves: Harnessing the Power of CAR-T to Combat Autoimmunity
What is autoimmune disease? Autoimmune disease a condition in which the body’s immune system mistakenly attacks the body itself. Thus far, more than 80 different autoimmune diseases have been identified, with some of the most prevalent including rheumatoid arthritis, Crohn’s disease, type 1 diabetes, and multiple sclerosis [1]. Autoimmune disease is one of the top ten causes of ...
By Indee Labs
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Project - Sublingual IL2 (BL SLIT I)
The aim of this project is to develop low dose IL-2 for treatment of early onset juvenile Type I diabetes. Low dose injectable IL-2 in animal models has been shown to restore the balance between regulatory and effector T cells and, in this way, can help to reverse autoimmunity and the development of type I diabetes. Looking ahead, we anticipate that having a suitable oral formulation of IL-2 to ...
By BioLingus AG
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Possible role of molecular mimicry in pathogenesis of Ebola virus: implications for a rational vaccine design
Ebola Virus (EBOV) presents a challenge for vaccine development because immune correlates of protection in humans are not well known. In earlier studies we developed a concept of local similarity which refers to resemblance of structural patterns of unrelated proteins as a function of their amino acid composition. The search for local similarities between human and EBOV proteins was performed. ...
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Rapid Point-of-Care Test for Determination of C-Peptide Levels
Abstract C-peptide is co-secreted with insulin and is not subject to hepatic clearance and thus reflects functional β-cell mass. Assessment of C-peptide levels can identify individuals at risk for or with type 1 diabetes with residual β-cell function in whom β cell-sparing interventions can be evaluated, and can aid in distinguishing type 2 diabetes from Latent Autoimmune Diabetes ...
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Diabetes faces iPeak technology
DiabetOmics DiabetOmics®, Inc. is a global, commercial stage medical diagnostics company pioneering innovative, non-invasive point-of-care tests that are especially useful in alleviating the substantial economic and public health burden of maternal health and diabetes. They operate in USA and India. The primary area of focus is the diabetes market with products related to the detection ...
By IUL S.A.
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Study of the pathogenic mechanisms of autoimmune myasthenia gravis - Case Study
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
By Inovarion
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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Beyond Fecal Microbiota Transplantation: Developing Drugs from the Microbiome
Abstract The transfer of live gut microbes may transform patient care across a range of autoimmune, metabolic, hepatic, and infectious diseases. One early approach, fecal microbiota transplantation, has shown promise in Clostridiodes difficile infection and the potential for improving clinical and public health outcomes for other antibiotic-resistant bacteria. These clinical successes have ...
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Serum 14-3-3η A Predictor Of Secondary Sjögren’s Syndrome In SLE
Do you have a patient with Systemic Lupus Erythematosus (SLE) that you suspect may also have Sjögren’s Syndrome (SS)? With shared clinical and serological features, overlapping SS with SLE is a comorbidity that is often challenging to identify to promptly assist clinical management. This may also lead to misdiagnoses of other connective tissue disorders. New data on 14-3-3η (eta) ...
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Suppressive effect of low-dose X-irradiation on type I diabetes non-obese diabetic (NOD) mice
We examined the effect of X-irradiation (0, 0.25, 0.5 or 1.0 Gy) on the onset of the type I diabetes (insulin dependent diabetes mellitus) in non-obese diabetic (NOD) mice. NOD mice are characterised by a progressive loss of insulin-producing β-cells in the pancreas by autoimmune mechanisms. The destruction of β-cells is known to be due to apoptosis induced by oxidative stress caused by ROS. In ...
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“Harmless” Bacteria Cause Autoimmune Disease
Organs influenced by immune dynamics in the gut.(1) A Gut Check for Tumor Overgrowth Enzymes Work Better in a Cage Are IPS Cells Safe for Therapeutic Use? Factors contributing to autoimmune disease development. (2) The human body is the site of a flagrant yet silent invasion. We host as many foreign organisms in and on us as we have cells that make up our own body. A particular ...
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Fibromyalgia Therapies and Treatments
In honor of National Fibromyalgia Awareness Day this month, we are doing our part to set the record straight on Fibromyalgia, a condition the MayoClinic calls “one of the most misunderstood disorders in medicine today.” Once thought to be an autoimmune or inflammatory disorder, specialists now agree that fibromyalgia is a disorder of the nervous system. It most commonly affects women ...
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Diabetomics Lumella - New Point-of-Care Blood Test Kit for Early Detection of Preeclampsia
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. We recently reported that many RA patients have anti-citrullinated albumin (ACA) ...
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