Autoimmune And Infectious Diseases Articles & Analysis: This-Year
12 articles found
Blocking CCR1 can blunt harmful inflammation but risks impairing protective immunity. Clinical Relevance: From Autoimmunity to Oncology In autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, CCR1 signaling sustains leukocyte infiltration into tissues. ...
The rat thymus, an essential organ in the immune system, plays a crucial role in the development and maturation of T-cells. Investigating the thymus of rats provides valuable insights into immunological processes and disease mechanisms. One of the most effective methods for preserving and studying the cellular architecture of the rat thymus is through the use of Formalin-Fixed Paraffin-Embedded ...
Tissue cross-reactivity studies play an essential role in the understanding of immune responses, particularly in the context of autoimmunity, transplant rejection, and vaccine development. These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
These proteins are vital for treating conditions such as cancer, autoimmune diseases, and infectious diseases. Beyond therapeutic uses, recombinant proteins are instrumental in research and diagnostics. ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. ...
Applications of Single-Domain Antibodies Single-domain antibodies have a wide array of applications across multiple fields: Therapeutics: They are being explored as potential treatments for various diseases, including cancer, infectious diseases, and autoimmune disorders, due to their ability to specifically target antigens. ...
Their size, ease of handling, and well-characterized immune system make them ideal candidates for studying disease mechanisms and therapeutic interventions. Understanding the cytokine and chemokine profiles in rats can provide insights into human diseases, as many of the biological pathways are conserved across species. ...
Customized assays can help identify key cytokines involved in immune regulation. Infectious Disease Studies: Cytokines play a significant role in the host response to infections. By measuring cytokine levels, researchers can gain insights into the pathogenesis of infectious diseases and the effectiveness of potential treatments. ...
In the realm of drug discovery, the search for innovative therapies often leads to new paradigms. One such paradigm that has gained significant traction in recent years is the development of PROTAC (Proteolysis Targeting Chimeras) technology. This groundbreaking approach unlocks new potential in targeting previously “undruggable” proteins, paving the way for transformative therapies ...
Understanding the immune system is fundamental to advancing biomedical research, especially in areas such as cancer, autoimmune diseases, and infectious diseases. Mouse models play a pivotal role in this field, as their immune system shares many similarities with that of humans. ...
This approach is especially beneficial for investigating diseases with immune dysregulation, such as cancer, autoimmune disorders, or infectious diseases, where multiple cytokines orchestrate pathological processes. ...
Human mesenchymal stem cells (hMSCs) are a remarkable type of stem cell found in various tissues, such as bone marrow, adipose tissue, and umbilical cord. These cells have garnered significant attention in the field of regenerative medicine and therapeutic research due to their unique properties and potential applications. Characteristics of hMSCs hMSCs possess the ability to differentiate into ...