Autoimmunity Articles & Analysis
99 articles found
Dysregulation of ubiquitination is a hallmark of numerous human diseases, including many cancers, neurodegenerative disorders like Parkinson's and Alzheimer's, and autoimmune conditions. How We Study the 'Ubiquitome': Ubiquitinated Proteomics Analysis Given its central role in health and disease, understanding which proteins are ubiquitinated, when, and how, is a major goal for ...
However, the same proteolytic activity that protects against pathogens can, when unregulated, contribute to tissue injury, autoimmune inflammation, and chronic disease progression. In recent years, recombinant ELANE protein has become an indispensable tool for researchers studying neutrophil function, protease regulation, and disease mechanisms, particularly in pulmonary, ...
Tissue cross-reactivity studies play an essential role in the understanding of immune responses, particularly in the context of autoimmunity, transplant rejection, and vaccine development. These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects ...
These proteins are vital for treating conditions such as cancer, autoimmune diseases, and infectious diseases. Beyond therapeutic uses, recombinant proteins are instrumental in research and diagnostics. ...
These chemokines protein allows researchers to study the functional dynamics of chemokine-receptor interactions in controlled environments, facilitating the development of targeted therapies for a range of diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. One of the most significant applications lies in cancer immunotherapy. ...
Their highly specific interactions with biological targets offer unprecedented precision in treating autoimmune disorders, cancers, and genetic conditions. However, their structural complexity presents unique manufacturing challenges, requiring specialized bioprocessing techniques, cold chain management, and sophisticated analytical methods. ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. Antibodies, which are proteins produced by the immune system, have the ability to specifically recognize ...
Applications of Single-Domain Antibodies Single-domain antibodies have a wide array of applications across multiple fields: Therapeutics: They are being explored as potential treatments for various diseases, including cancer, infectious diseases, and autoimmune disorders, due to their ability to specifically target antigens. ...
By measuring cytokine levels, researchers can gain insights into the pathogenesis of infectious diseases and the effectiveness of potential treatments. Autoimmune and Inflammatory Diseases: Cytokines are central to the development and progression of autoimmune and inflammatory diseases. ...
Versatile Applications: This panel can be applied in various research settings, including cancer immunology, autoimmune diseases, infectious diseases, and neuroinflammation. It helps elucidate the roles of specific cytokines and chemokines in disease mechanisms and therapeutic responses. ...
As a result, PROTACs have emerged as a promising strategy in various fields such as oncology, neurodegenerative disorders, and autoimmune diseases. The Role of Discovery Services Discovery services play a critical role in the early stages of PROTAC development. ...
Understanding the immune system is fundamental to advancing biomedical research, especially in areas such as cancer, autoimmune diseases, and infectious diseases. Mouse models play a pivotal role in this field, as their immune system shares many similarities with that of humans. ...
This approach is especially beneficial for investigating diseases with immune dysregulation, such as cancer, autoimmune disorders, or infectious diseases, where multiple cytokines orchestrate pathological processes. ...
This characteristic makes hMSCs a promising candidate for treating autoimmune diseases and minimizing tissue rejection in transplant scenarios. ...
At present, recombinant protein drugs are widely used in various fields such as tumors, autoimmune diseases, metabolic diseases, geriatric diseases, and degenerative diseases.FcyR (Fc gamma receptors) are receptors expressed on the surface of immune cells, primarily responsible for recognizing and binding to the Fc (Fragment crystallizable region) part of antibodies. ...
This approach has opened new avenues for immunotherapy, providing hope for treating conditions like cancer, autoimmune disorders, and genetic diseases. Understanding Primary T Cells Primary T cells play a vital role in the body’s defense mechanism. ...
Antibody drugs have shown remarkable therapeutic effects in the treatment of various diseases, such as cancer, autoimmune diseases, inflammatory diseases, immune regulation, and ophthalmic diseases.In the production process of antibody drugs, the culture medium plays a very important role. ...
This process also aids in screening for monoclonal antibodies with high specificity and affinity, crucial for therapeutic applications in oncology, infectious diseases, and autoimmune disorders. 4. Glycan-Based Drug Discovery The study of glycan structures has led to the discovery of novel drug candidates targeting glycan-related pathways. ...
Conditions such as diabetes and autoimmune disorders can affect the health of the cornea and, by extension, the epithelial cells. ...
They play a crucial role in the development of diagnostic kits for diseases such as HIV, hepatitis, and various autoimmune disorders. Research and Development Synthetic peptides are invaluable in research settings for studying receptor interactions, enzyme activities, and signal transduction pathways. ...