Biologic Therapeutic Articles & Analysis: Older
8 articles found
Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. This process involves the integration of specific DNA sequences into precise loci within the genome, allowing scientists to explore gene function, model diseases, and develop new treatments. ...
Peptidomimetics are structural analogs of peptides or proteins that mimic their biological activities. They are designed to overcome limitations associated with peptides, such as poor stability and bioavailability by preserving or enhancing their functions. ...
Fc-Fusion Glycosylation and Its Biological Significance Glycosylation Therapeutic monoclonal antibodies (mAb) or mAb variant molecules such as Fc-Fusion have an N-linked glycan coherent sequence of (Asn)-X-Ser/Thr (where X is any amino acid except Pro) at the Asn297 position of the heavy chain of the constant CH2 domain, and some mAb also have additional ...
Scientists continuously face pressure to purify biologics like protein therapeutics with maximum yield while minimizing cost and developing processes as quickly as possible. ...
During lead discovery, an intensive search ensues to find a drug-like small molecule or biological therapeutic, initially a hit that, through further validation and evolution, can become a development candidate that will progress into preclinical and, if successful, into clinical development and ultimately be a marketed medicine. ...
Different from traditional small molecule inhibitors and antagonists, protein degradation technology has developed rapidly in recent years because of its ability to induce the degradation of therapeutic target proteins, providing a new idea for the development of new drugs. ...
In the future, new strategies based on nanofluidic chip technology to achieve exosome loading are expected to develop into a platform-type tool to load different exogenous substances with biological significance and clinical therapeutic effects into exosomes and get more applications in biological research and cell-free ...
Therefore, recombinant glycoprotein biologics intended for human therapeutic applications are usually manufactured in mammalian cell systems, which have protein glycosylation pathways that can provide terminal sialylation (Walsh, 2010). ...