biomarker Articles
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Linking survival and biomarker responses over time
The practical usefulness of biomarkers is limited by the complexity of linking their responses to life‐history traits of the organisms (e.g., survival, growth, reproduction) over time. Here we present a first attempt to simultaneously model biomarker responses and survival over time with a toxicokinetic‐toxicodynamic approach. Even though more work is clearly needed, the present study provides ...
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Petroleum biomarkers as tracers of Exxon Valdez oil
Over the past quarter century, petroleum biomarkers persisted in sequestered Exxon Valdez oil in Prince William Sound and the Gulf of Alaska, hence the oil remained identifiable. These biomarkers are molecular fossils derived from biochemicals in previously living organisms. Novel pattern matching indicated the presence of Alaska North Slope crude oil (ANSCO) over the entire observation period ...
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Environmental toxicity of PFCs: An enhanced integrated biomarker (EIBR) assessment and structure‐activity analysis
Perfluorinated chemicals (PFCs) are a group of compounds with varying carbon chains and functional groups. However, available toxicity study is mainly limited to dominant species. While many other PFCs are detected in the environment and biota, it is important to extend toxicity study to different types of PFCs to better assess their environmental and ecological impacts. In the present study, ...
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Rho kinase inhibition in Amyotrophic Lateral Sclerosis - Case Study
REAL is a phase 2a open-label study to assess preliminary safety, tolerability, and effect on clinical outcomes as well as neurodegeneration biomarkers of BRAVYL in patients with ALS. The study will enroll approximately 20 patients, all of whom will be treated with BRAVYL for 24 weeks. ...
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Survivin as a biological biomarker for diagnosis and therapy
Survivin (SVN) is a member of the inhibitor of apoptosis (IAP) protein family that promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated with autoimmune disease, hyperplasia, and tumors and can be used as a biomarker in these diseases. SVN is widely recognized as a tumor-associated antigen (TAA) and has become an important target for cancer diagnosis and ...
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Open-Source AI Platforms: Driving Success through Diversity
Digital biomarkers can open a world of possibilities in understanding the nuances of a patient’s behavior and response to treatment. Rather than relying on subjective perceptions of how a patient is responding, digital biomarkers treat patient observation more like an engineering problem. Such precise, sensitive measurements can ultimately influence the future of a patient’s care plan ...
By AiCure
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Dermal exposure of Eisenia andrei earthworms: Effects of heavy metals on metallothionein and phytochelatin synthase gene expressions in coelomocytes
Parameters like total number of coelomocytes, riboflavin content in coelomocytes, expression of genes implied in metal homeostasis and detoxification mechanisms can be used as biomarkers in order to assess the impact of metals on Annelids. Defense biomarkers (detoxification gene expressions and coelomocyte parameters) were investigated in the ecotoxicologically important species Eisenia andrei ...
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Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids
We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)- derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorigenicity, as well as pyrrolizidine alkaloid exposure. In this paper, we report ...
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MRE11 and H2AX biomarkers in the response to low-dose exposure: balance between individual susceptibility to radiosensitivity and to genomic instability
Unrepaired and misrepaired DNA Double-Strand Breaks (DSBs) were shown to be the key events of radiation-induced toxicity (radiosensitivity) and genomic instability (cancer proneness), respectively. We have previously shown that immunofluorescence with ?-H2AX and MRE11 biomarkers may account for unrepaired and misrepaired DSBs for doses higher than 1 Gy. Three radiosensitivity groups had been ...
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Rehabilitation of Maria after fall in WZC - Case Study
Resident in an assisted living facility Pain problems after slight fall Difficulty moving shoulder, wrist and hip Two weeks ago, Maria had an unfortunate fall in the hallway of the assisted living facility where she resides. Since this incident, she has suffered from persistent pain at the level of both her shoulders, right hip and wrist. Although the mobility of the joints was ...
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Environmental exposure to pesticides: biomarkers in non–invasively collected matrices in prenatal development and childhood
The collection of invasive samples from susceptible populations may suffer from ethical and practical limitations that restrict the routine application of human biomonitoring. Moreover, the accumulation of exposure data will be unsuccessful in risk assessment if not integrated through the appropriate sets of biomarkers for early biological responses. This paper reviews the usefulness and ...
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Clinical Proteomics in COVID-19 Infection
Earlier this month, researchers at Francis Crick and Charité- Universitätsmedizin Berlin published a study in Cell Systems that identified protein biomarkers from patients hospitalized with COVID-19. In this study, they collected serum and plasma samples from individuals shortly after being hospitalized to find which proteins might be associated with severe outcomes. Their ...
By PercayAI
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RNA Sequencing Increases the Chance of RNA Biomarker Discovery
Biomarkers are defined as measurable biological characteristics that are associated with normal or pathological conditions. They possess clinical relevance, including diagnostic, prognostic, and predictive values. RNA, not only an essential part of the central dogma, is certainly a relatively untapped resource for biomarker discovery of various diseases. Cumulating data shows that RNA ...
By CD Genomics
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Cost-Effectiveness of Urinary Biomarker Panel in Prostate Cancer Risk Assessment
Abstract Purpose: SelectMDx (MDxHealth®) is a panel of urinary biomarkers used in conjunction with traditional risk factors to individualize risk prediction for clinically significant prostate cancer. In this study we sought to characterize the effectiveness of SelectMDx in a population of American men with elevated prostate specific antigen. Materials and methods: We developed a ...
By MDxHealth
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Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance
Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, as crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migratory success and fitness. Yet the sensitivity of early life‐stage salmon to dilbit ...
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Assessment of a urinary TRUS/biomarker-based risk score as inclusion criteria for multiparametric MRI to detect clinically significant prostate cancer
BACKGROUND Non-invasive techniques like urinary biomarkers and multiparametric Magnetic Resonance Imaging (mpMRI) show great promise for the detection of clinically significant prostate cancer (PCa), leading to a reduction of over-diagnosis and over-treatment. Apart from yet to be established diagnostic accuracy is the systematic use of mpMRI challenging due to the high cost of setting up, ...
By MDxHealth
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Cercare Perfusion Reveals Microvascular Changes in COVID-19 - Case Study
Introduction Neurologic complications are frequently reported in COVID-19, but our understanding of their pathophysiologic causes and neuroanatomical correlates is limited. While several structural brain imaging findings have been reported in COVID-19, including non-spherical signal abnormalities on Susceptibility-Weighted Imaging (SWI), conventional perfusion imaging has not provided consistent ...
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Ovarian structure protein 1: A sensitive molecular biomarker of gonadal intersex in female Japanese medaka after androgen exposure
Intersex in gonochoristic fish can be induced after exposure to androgens and estrogens. The main objective of the present study was to identify biomarkers that would be predictive of intersex in Japanese medaka (Oryzias latipes) after exposure to synthetic hormones. First a gene was identified, ovarian structure protein 1 (osp1), with strong female‐specific expression during gonadal ...
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Infrared spectroscopy of human bone marrow: evidence of structural changes during acute leukemia
Fourier transform infrared (FTIR) spectroscopy was explored as a means to distinguish newly diagnosed of acute lymphoblastic leukemia from disease free bone marrow samples. Characteristic bands alterations were identified in both healthy and diseased samples arising from cellular protein, lipid and DNA. There were specific changes that affected the secondary structure of proteins that appeared in ...
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Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study
Abstract Background: Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality, most of which occurs in low and middle-income countries. The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous ...
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