biomaterial Articles
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Silicone Elastomer-based combinatorial biomaterial gradients for high throughput screening of cell-substrate interactions
Shout out to Greeshma Mohan a recent SyringePumpPro owner who has published a paper titled Silicone Elastomer-Based Combinatorial Biomaterial Gradients for High Throughput Screening of Cell-Substrate Interactions. Greeshma is currently working at the University of South Florida. Pictured here are two New Era Syringe pumps working with a Harvard Apparatus syringe pump in support of ...
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Project - Rising competitiveness of early stage researchers and research management in Latvia (RISEus2)
H2020 WIDESPREAD-05-2020: Twinning project GA No 952347 Click here for the News on the project implementation General information Project coordinator: Professor Dr.sc.ing. Janis Locs Project period: 1.01.2021.-31.12.2023. Project Partners: AO Research Institute Davos, Switzerland (ARI), Institute National Polytechnique de Toulouse CIRIMAT, France (INPUT-CIRIMAT), FORM-Lab Frankfurt Orofacial ...
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Review of chatter in micro and macro cutting operations machining biomaterials
Chatter presents one of the main problems in quality of machined surfaces limiting tool life, productivity and tolerances. Chatter in milling and turning operations has been extensively analysed however, drilling operations have been neglected due to the complexity of drilling tools and problems that develop in the modelling of the tool. In this paper, an overview of chatter vibrations and ...
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Molecular interactions of degradable and non-degradable polymers with hydroxyapatite influence mechanics of polymer-hydroxyapatite nanocomposite biomaterials
Implant materials composed of hard and soft phases (composite materials) have shown much promise for total bone replacement. Interfacial interactions between the components in these composite biomaterials affect the overall mechanical response. Here, the role of interfacial interactions on the load deformation behaviour of soft phase (polymer) have been analysed using constant velocity Steered ...
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Electrodeposition of calcium phosphate coatings on titanium alloy implant at different Ca/P ratios and different times
Brushite (CaHPO4.2H2O) was coated on titanium alloy substrate by electrochemical deposition technique. Then, it was converted to hydroxyapatite [Ca10 (PO4)6 (OH) 2] by NaOH treatment. Different Ca/P ratios (0.335, 0.67, 1.0, 1.667) were applied. The surface morphology, chemical composition and phase identification of the coatings were investigated. The results showed that the coating layer is ...
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Label-free detection of biomaterials using terahertz technology
We present terahertz (THz) absorption spectra of various biomolecules (tripeptide gly-gly-gly and oligo-nucleotides poly[A] and poly[C]). While the tripeptide shows unique resonances in the THz range due to intramolecular vibrations, the different oligo-nucleotides can be distinguished due to different absorption properties. In space-resolved THz free-space measurements, we were able to ...
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Electrospun nanofibres of polycaprolactone, and their use for tendon regeneration
Inferior scar tissue formed when injured tendons heal often results in ongoing pain and site morbidity. With current treatments being ineffective, there is a clinical need for a tissue engineered approach. Electrospinning produces nanofibres with morphologies and architectures similar to the natural extra cellular matrix. Research incorporating electrospinning for tendon regeneration is limited. ...
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Bioactive compounds obtained by immobilisation of serine protease inhibitors
We studied the preparation of polymeric membranes formed of solutions of poly–3–hydroxybutyrate (PHB) and chitosan. PHB–chitosan biomaterials from these solutions may form various structural types, which determine the biodegradation time, the adsorption capacity, and the kinetics of the release of medicinal compounds from polymeric matrices. Serine protease inhibitors, SERPINs, continue to catch ...
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The effect of mixing technique on fatigue of bone cement when stress concentrations are present
Mixing techniques used to reduce porosity in bone cement demonstrate large improvements in fatigue behaviour in test specimens, but do not appear to reduce the rate of loosening of implants in vivo. We examined data showing the effect of notches on fatigue strength and found, surprisingly, that notches with low stress-concentration factors (Kt Keywords: mixing technique, fatigue strength, bone ...
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Influence of a novel radiopacifier (nano-sized strontia particles) on in vitro properties of a PMMA bone cement for use in total joint replacements
In literature reports on strontia-containing PMMA bone cements, the strontia was combined with another material, micron-sized particles were used and in vitro fatigue data are sparse. The present report is on the in vitro characterisation of a strontia-containing PMMA bone cement in which nano-sized strontia particles that were not combined with any other material were used (NANOSRO cement). ...
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Evonik Enhances Glycolide-Based Polymer Portfolio for Medical-Textile Materials
Evonik has announced the signing of an exclusive global agreement with ITV Denkendorf Produktservice (ITVP), a German-based R&D and manufacturing leader for medical-textile materials. New Platform of Glycolide-based Polymers Under the agreement, Evonik will expand its market-leading RESOMER® portfolio with the launch of a new platform of glycolide-based polymers suitable to produce ...
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Diamond coated microtools for machining compact bone
The structure of compact bone is heterogeneous and as such, is difficult to shape by cutting tools during clinical surgical practices. The structure of bone can have a devastating effect on the performance of the cutting tool unless it is coated with a thin solid film that is wear resistant. The paper investigates the use of diamond coated cutting tools to prepare bone for prosthetic implants and ...
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Synthesis and characterisation of nano alumina dental filler
The production of alumina nanoparticles using a low power plasma torch and creating a nanocomposite for use in dental applications were investigated. Upon fabricating the nanocomposite based on alumina nanoparticles, the mechanical properties were studied using instrumented nanoindentation and compared to three standard dental fillers. Several nanocharacterisation techniques were employed in the ...
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Imaging and analysis of chip formation during orthogonal cutting of titanium alloy Ti-6Al-4V
Orthogonal cutting of titanium alloy Ti-6Al-4V was investigated in a series of continuous and interrupted turning tests. Direct observation of the chip formation zone was achieved using a high speed imaging system with a long-distance microscope lens. Frame rates from 20,000 to 50,000 frames per second were used to record the chip formation cycle over a range cutting speeds from 4 to 150 m/min ...
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Growth and behaviour of bovine articular chondrocytes on nanoengineered surfaces: Part I
Surface modification, using biomaterials to mimic in vivo cell microenvironment, plays an important role in tissue engineering. Current work studies the growth and behaviour of primary bovine articular chondrocytes on layer-by-layer self-assembled nanofilms of 11 different biomaterials, including polyelectrolytes and proteins [poly(styrene sulphonate) (PSS), fibronectin, poly-L-lysine (PLL), ...
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Clinical Performance of hydrogel- bioceramic Putty for Bone Regeneration in maxillofacial surgery
The article shows the valorization of results of a non interventional clinical study of 78 patients with the product In’Oss™ in association with a collagen resorbable membrane in maxillofacial surgery. The safety and efficacy of In’Oss has been demonstrated, as well as the performance of EZ Cure membrane associated to it. G. Daculsi et al. «Clinical Performance of ...
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Induction of adipose tissue regeneration by chemically-modified hyaluronic acid
Hyaluronan was modified by amidation of the carboxyl groups with dodycyl amides to produce a viscous gel (HYADD3). Small aliquots were implanted intramuscularly in Wistar rats at a concentration of 30 mg/ml for up to 12 weeks. Standard histology and immunohistochemistry demonstrated low levels of inflammation at all time periods, absence of any fibrous capsule coupled with the presence of mature ...
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Sorption of paracetamol onto biomaterials
Pharmaceutical residues released into the environment are posing more and more public health problems. It is worthwhile to study the retention of pharmaceuticals residues by adsorption on solid supports. Batch sorption experiments are intended to identify the adsorption isotherms of the pharmaceutically active ingredient on the biomaterials. The results obtained in this study have shown that ...
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Bone cement: an overview
Polymethylmethacrylate bone cement is a widely utilised material in the field of orthopaedic surgery and specifically total joint arthroplasty. Despite this, its mechanical properties are poorly understood by the end-user and there is controversy over the manner in which the material should be tested and the effects some commonly used techniques have on its mechanical properties. This article ...
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Tepha - case study
Tepha Inc. is a medical device firm that develops and commercializes innovative products based on the company’s proprietary PHA (polyhydroxyalkanoate) bioaterial technology. Tepha began working with POS in 2002 to develop its biopolymer resin production processes. These novel process had not yet been demonstrated at the pilot plant scale when the company started working with POS. Today, ...
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