blindness Articles
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Gertsen Blinded Validation Project
Summary OTraces in collaboration with the Gertsen Institute in Moscow performed a blinded validation study on OTraces breast cancer detection products, the CDx Chemistry System for processing automated tests for detection of cancer; BC Sera Dx Immunochemistry test kit for the measurements of proteins that are predictive as a group of the presence on breast cancer in women; and the OTraces Cancer ...
By OTraces Inc.
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Blinded Validation Projectfor Prostate Cancer Test Johns Hopkins University Medical Center, Brady Urology Institute
Summary OTraces, in collaboration with the Johns Hopkins Medical Center, Brady Urology Institute (JHMC), performed a blinded validation study on OTraces prostate cancer (PCa) detection products. The blinded validation project involves two phases, and the first has been completed: Phase I: Blinded third party validation of the test for men with aggressive PCa, Gleason score of 7(4+3), 8, 9, and ...
By OTraces Inc.
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Onchocerciasis Vaccine Research - Case Study
What is onchocerciasis? Onchocerciasis or river blindness is a human disease caused by the filarial worm Onchocerca volvulus, and it endangers approximately 120 million people each year globally. When the worms become adults, they can live for over a decade in knots ("nodules") under the skin and release millions of of smaller worms or microfilariae. Circulating microfilariae cause many clinical ...
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Randomized controlled trial comparing three methods of liver retraction in laparoscopic Roux-en-Y gastric bypass
Article Overview Traditional liver retractors require another wound for insertion, are bulky, and may cause iatrogenic liver injury. This study aimed to evaluate differences between three methods of liver retraction during laparoscopic Roux-en-Y Gastric bypass (LRYGB) and to compare novel liver retraction techniques with the traditional mechanical liver retractor in a randomized controlled ...
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The QUEST Post-Amputation Pain Study - Case Study
The QUEST study (High-FreQUEncy Nerve Block for PoST-Amputation Pain), is a randomized controlled study of 180 patients at 25 clinical study sites in the U.S. Recruitment for the study was completed in late 2021. Results are blinded until after participants have finished a twelve-month follow-up. ...
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Microbes4U - Case study
The Microbes4U® study is the first randomized double-blind placebo-controlled pilot study to evaluate the effects of pasteurized Akkermansia muciniphila administered in humans. The main objectives of the Microbes4U® study were to determine the safety, tolerance and metabolic parameters (i.e., insulin resistance, circulating lipids, visceral adiposity, body mass) after 3 months of daily ...
By A-Mansia
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Case Study B - Liquid Biopsy
X-ZELL is collaborating with Singapore General Hospital (SGH) and the National University Hospital Singapore (NUH) to explore how X-ZELL single-cell diagnostics may aid in the early detection of clinically significant prostate cancer in whole blood. The prospectively blinded, 400-patient multi-centre study officially commenced in 2020 and will lay the foundation for the launch of a commercially ...
By X-Zell Inc.
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Sight Conservation Project - Case study
Berea Lions Club Foundation is an organization made up of men and women who volunteer their time to humanitarian causes in their local, state, country, and world communities. Berea Lions Club Foundation is a member of Lions Club International; an association founded in Chicago, Illinois, USA, in 1917. Lions Club International has grown into the world's largest service organization with more than ...
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History of the Vaccine
The first vaccine, created by Edward Jenner, was used to fight against cowpox in 1796 in England. Though rarely seen today, cowpox, a viral infection, was contracted often by milkmaids before the late 1700s. When someone touched the udder of a cow that was infected, they could contract cowpox. The cowpox virus is like smallpox; however, it is not as deadly as smallpox. Smallpox is a virus that ...
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Three-Port Versus Standard Four-Port Laparoscopic Cholecystectomy: A Randomized Controlled Clinical Trial in a Community-Based Teaching Hospital in Eastern Nepal
Article Overview The prevalence of laparoscopic cholecystectomies has increased in frequency leading to an increase in both surgeoi experience and technical refinements, specifically the number of ports used and their size. The 3-port laparoscope cholecystectomy has already been established as being safe. The design of this study sought to determine if ther were any additional advantages compared ...
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Anti-HIV and anti-inflammatory action of iodine-lithium-α-dextrin is accompanied by the improved quality of life in AIDS patients
Clinical efficacy, tolerability and safety of various doses of Iodine-Lithium-α-Dextrin (ILαD) monotherapy have been evaluated in 56 HIV-infected patients enrolled in double blind uncontrolled randomised study during 48 weeks follow-up period. ILαD was administered intravenously three times over five days with intervals of 23 weeks between treatments for a total of 12 infusions in 4 cycles. HIV-1 ...
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CanaQuest President Interviewed by the Wall Street Analyzer
The attached is the transcript of an interview conducted by the Wall Street Analyzer with Paul Ramsay, President of CanaQuest Medical Corp. and posted on the Wall Street Analyzer’s website on January 5, 2023. Additionally, the full interview can be listened to on the Wall Street Analyzer’s website - Canaquest Medical Corp (OTC: CANQF) | The Wall Street Analyzer Interview Notes: 1. ...
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Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated vaccine against herpes simplex virus type 1 (HSV-1), a widespread human pathogen that can cause ...
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Generating a robust prediction model for stage I lung adenocarcinoma recurrence after surgical resection
Abstract Lung cancer mortality remains high even after successful resection. Adjuvant treatment benefits stage II and III patients, but not stage I patients, and most studies fail to predict recurrence in stage I patients. Our study included 211 lung adenocarcinoma patients (stages I–IIIA; 81% stage I) who received curative resections at Taipei Veterans General Hospital between January ...
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Dyve Biosciences enrolls first patient in gout trial
Dyve Biosciences announced today that it enrolled its first patient in the Phase 2 clinical study of its DYV-700 topically administered therapeutic for acute gout treatment. Thousand Oaks, Calif.–based Dyve won FDA clearance to begin the Targets Phase 2 trial in December 2019. The double-blind, placebo-controlled, randomized clinical trial is set to evaluate the efficacy of DYV-700 in ...
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Blood pressure–lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor
Abstract Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we ...
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ReActiv8-B Trial 2-Year Data Publication in Neuromodulation
Abstract Background Impaired neuromuscular control and degeneration of the multifidus muscle have been linked to the development of refractory chronic low back pain (CLBP). An implantable restorative-neurostimulator system can override the underlying multifidus inhibition by eliciting episodic, isolated contractions. The ReActiv8-B randomized, active-sham-controlled trial provided ...
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Functional Electrographic Flow Patterns in Patients with Persistent Atrial Fibrillation Predict Outcome of Catheter Ablation
Aims: Electrographic flow (EGF) mapping is a method to detect action potential sources within the atria. In a double-blinded retrospective study we evaluated whether sources detected by EGF are related to procedural outcome. Methods: EGF maps were retrospectively generated using the Ablamap® software from unipolar data recorded with a 64-pole basket catheter from patients who previously ...
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Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1 (F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
Abstract Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular ...
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Everything we know About AMD and Dark Adaptation
When automated dark adaptometry was first commercialized, many of us had more questions than answers with regard to using this information for detecting AMD and monitoring disease progression. But with more than seven years of practical in-office experience performing dark adaptation testing on thousands of patients, the tables have turned. This technology offers a safety net for ...
By MacuLogix
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