blood donor Articles
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Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in Spain
Despite the widespread occurrence of bovine spongiform encephalopathy (BSE) in European countries in the late 1990s and the European Commission Scientific Steering Committee (SSC) report that cattle in Spain were likely infected with BSE agent, Spanish authorities continued to consider their country BSE-free. Some key European Union (EU) regulations to reduce BSE risk were enforced with delay, ...
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Preliminary evidence of efficacy from an open label trial of a therapeutic AIDS vaccine derived from the blood of HIV-positive donors
Two earlier reported studies indicated the beneficial clinical effects of THIVAC, a therapeutic HIV vaccine derived from the blood of HIV-positive donors. However, in those studies no stringent statistical analysis to support the beneficial clinical outcome was attempted. This report retrospectively analyses the effect of the therapy on the CD4 counts in 272 treated individuals who had at least ...
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Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease risk management in Italy
Italy experienced two imported cases of bovine spongiform encephalopathy (BSE) in 1994 and viewed the disease as a 'foreign' problem. Early, precautionary actions including: a 1989 ban on UK meat and bone meal (MBM), 1990 ban on UK beef, 1994 domestic ban on mammalian MBM to ruminants, and 1996 ban on UK live cattle, protected Italy from a much larger outbreak. In 2001 Italy implemented an ...
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Maintaining Quality in Stem Cell Products: Recent Developments in Regulation (Series Part 1 of 4)
Background Stem cells are naturally occurring cells in the body that have the ability to divide and produce a range of different cell types. They are important in the growth and development of the body as well as repair after injury. The past few years have brought a dramatic increase in the body of knowledge concerning stem cells, and their research and investment into uses in medicines1. ...
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Is there reliable experimental evidence for different dicentric yields in human lymphocytes produced by mammography X-rays free-in-air and within a phantom?
We examined the production of dicentrics in human lymphocytes irradiated with 29 kV X-rays to a depth of 13.5 mm in a PMMA phantom. For these irradiation conditions, which are appropriate for the diagnostic application of mammography X-rays, a coefficient of (5.88±0.66)×10–2 Gy–1 of the linear quadratic dose–response relationship was determined. This value does not differ significantly from the ...
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What is the difference between infection and disease?
Disease-causing microbes are often found in the human microbiome. So, when does the presence of pathogenic microbes indicate an infection? And when does the presence of infection explain disease? What is an infection? What is a disease? A disease associated with microbes is the outcome of interaction(s) between a microbe(s) and its host in which the host suffers some sort of damage. ...
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Blood Storage and Preservation
How Is Blood Stored and Preserved? Blood storage is an important process in the blood banking industry as it helps maintain the quality of blood and its medical effectiveness. Blood can be stored in a few different ways, but the most common method is refrigeration.Blood banks depend on donors to provide blood and blood components. When blood is collected from a donor, it must be processed to ...
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Controlling Intraoperative Hemorrhage During Burn Surgery: A Prospective, Randomized Trial Comparing NuStat Hemostatic Dressing to the Historic Standard of Care
Introduction: One of the primary intraoperative challenges during burn surgery is to adequately excise the burn while avoiding massive hemorrhage. This has become increasingly important, as we see more burn patients that are older and with more medical comorbidities. While adequate excision down to healthy tissues for deep burns is essential for skin graft to take, it also leads to active ...
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Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma
Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. Using the K562-mb15-41BBL cell line as a stimulus, we obtained large numbers of activated NK cells from the peripheral blood of healthy donors. ...
By Nkarta, Inc.
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Autotransfusion device maker ships units to Ukraine
The developer of an autotransfusion device for collecting and cleaning a patient’s lost blood is sending hundreds of units to Ukraine as casualties climb from the Russian invasion. Baltimore-based Sisu Global Health has already sent 1,005 of its Hemafuse devices to hospitals in Kyiv and is planning a third shipment of 500 more any day now, co-founder and President Gillian Henker said. ...
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Meet the Entrepreneur: Carolyn Yarina and Gillian Henker, Sisu Global
At FINCA Ventures, we look for entrepreneurs leveraging market-based solutions to create large-scale, lasting social impact. In this series, “Meet the Entrepreneur,” we’ll be taking you into the minds of the intrepid leaders at our portfolio companies who boldly venture into markets in need of positive disruption. Globally, there is a shortage of over 100M units of donor blood ...
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Blood pressure–lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor
Abstract Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we ...
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What is the reliability of chromosomal aberration assays as biomarkers of individual sensitivity towards ionising radiation?
The development of biomarkers of susceptibility or sensitivity towards ionising radiation is important for the identification of individuals who may be at increased risk for the development of cancer after occupational, environmental or medical exposures. In this study we investigated the inter- and intra-individual variation of the MN assay and the G2 assay in irradiated lymphocytes to assess ...
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Some Interesting Facts About Liver Transplant And Who Needs It
Situated at the right hand part of your abdominal cavity, liver is the largest organ of your body. This dark brown organ weighs around 1.2 kg. You should know that all the blood which leaves from stomach and your intestine passes through this organ. Liver is solely responsible for carrying away waste products from your blood. Liver is important in your body for a number of reasons, such as, it ...
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Fresh Frozen Plasma Storage
Correct fresh frozen plasma storage is vital for safe and efficient treatment of patients with blood clotting disorders in various situations.This article will explore fresh frozen plasma preparation, storage and uses and discuss the Froilabo products that can aid your fresh frozen plasma storage.Fresh Frozen Plasma PreparationPlasma is the liquid portion of whole blood. It contains many ...
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