blood fractions Articles
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TOWARDS IMPROVED MODELS FOR PREDICTING BIOCONCENTRATION OF WELL‐METABOLIZED COMPOUNDS BY RAINBOW TROUT USING MEASURED RATES OF IN VITRO INTRINSIC CLEARANCE
Models were developed to predict the bioconcentration of well‐metabolized chemicals by rainbow trout. The models employ intrinsic clearance data from in vitro studies with liver S9 fractions or isolated hepatocytes to estimate a liver clearance rate which is extrapolated to a whole‐body biotransformation rate constant (kMET). Estimated kMET values are then used as inputs to a mass‐balance ...
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What is heart failure with preserved ejection fraction (HFpEF)?
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
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Ancora Heart Announces Positive Safety and Efficacy Data from Study of First-of-Its-Kind Investigational Heart Failure Therapy
Interim study results from systolic heart failure patients treated with percutaneous therapy designed to improve left ventricular function presented at TCT 2019 Santa Clara, Calif.–September 25, 2019–Ancora Heart, Inc., a company developing a novel therapy to address heart failure, today announced results from an interim analysis of heart failure patients treated in the CorCinch FMR ...
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