breast tissue Articles
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Raman ‘optical biopsy’ of human breast cancer
Abstract Raman imaging (RI) is a novel method of medical diagnostics of human breast cancer and has a potential to become a routine optical biopsy. Up to date the present study is the most statistically reliable Raman analysis based on data of normal, benign, and cancerous breast tissues for 146 patients. This paper present the first Raman ‘optical biopsy’ images of the normal and ...
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Raman imaging at biological interfaces: applications in breast cancer diagnosis
Abstract Background: One of the most important areas of Raman medical diagnostics is identification and characterization of cancerous and noncancerous tissues. The methods based on Raman scattering has shown significant potential for probing human breast tissue to provide valuable information for early diagnosis of breast cancer. A vibrational fingerprint from the biological tissue provides ...
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Segmentation of the Main Structures in Hematoxylin and Eosin Images
Pathologists conduct a biopsy on a tissue when a carcinoma case for a patient is suspected. They stain the cells on that tissue using some biochemical materials that react with a certain cell element. They put stained cells onto a slide and examine the cells by using an optical microscope device. In our case, we will focus on H&E stained breast tissue samples. Pathologists keep track of a ...
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MicroRNA-155 is regulated by the transforming growth factor β/smad pathway and contributes to epithelial cell plasticity by targeting RhoA
Transforming growth factor β (TGF-β) signaling facilitates metastasis in advanced malignancy. While a number of protein-encoding genes are known to be involved in this process, information on the role of microRNAs (miRNAs) in TGF-β-induced cell migration and invasion is still limited. By hybridizing a 515-miRNA oligonucleotide-based microarray library, a total of 28 miRNAs were ...
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New Breast Imaging Technology: The Koning Difference
Revolutionizing breast cancer detection Breast cancer is the most diagnosed cancer in women in the United States and the second leading cause of cancer death in American women.1 It is also treatable if detected early enough. While there are various cancer detection modalities available, current breast imaging devices fail to expose as much as 35% of breast cancers and that number increases to ...
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An Automated and Accurate Methodology to Assess Ki-67 Labeling Index of Immunohistochemical Staining Images of Breast Cancer Tissues
Automatic scoring of Ki-67 with digital image analysis would improve the accuracy of the diagnostic. However, automatic Ki-67 assessment is very challenging due to complex variations of cell characteristics. In this paper, we propose an integrated framework for accurate Ki-67 scoring. The main contributions of our method are: a robust cell detection algorithm to detect all tumor and non-tumor ...
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Distribution of Oxytetracycline residues in eggs from orally administered hens
Twenty five-week old hens (n = 6) were administered with an oral dose of 75 mg of Oxytetracycline (OTC) hydrochloride per day per head for five consecutive days and its residues in eggs as well as breast, leg and liver tissues were analysed by a high-performance liquid chromatography-ultraviolet visible detection (HPLC-UV) technique. The highest OTC residue concentration in egg white (0.5944 µg ...
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The Biological Importance and Research Ideas of Transfer Ribonucleic Acid (tRNA)
Transfer RNA (Transfer Ribonucleic Acid, tRNA) is the most abundant short-chain non-coding RNA molecule in the organism. It carries and transports amino acids, participates in protein translation, and is an important bridge connecting mRNA and protein. Although tRNA is widely present in organisms, different body genomes have different preferences for specific codons, which leads to differences in ...
By CD Genomics
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Closing the "tunnel of cells" to slow cancer
Recent research has uncovered an especially aggressive mechanism for the spread of a particularly aggressive type of breast cancer, in which the NUP93 protein plays a key role. Because this protein creates a "tunnel" in the nuclear membrane, cancer can gain access to the cell's DNA and exploit it to satisfy its own goals, such as increasing the cell's ability to migrate and spread the disease ...
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Delivering a precision medicine programme at scale
The Covid-19 pandemic highlighted the disparity between those who succumbed to severe illness while others remained relatively unaffected, underscoring the urgent need to shift the healthcare industry’s focus from a one-size-fits-all approach to more personalised healthcare. Personalised medicine promises to transform healthcare with treatments tailored to a patient’s unique genetic ...
By Lifebit
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Development of a System for the Early Diagnosis of Breast Cancer
We are now developing a system which allows the visualization of the structure and tissue associated with breast cancer, which is difficult to achieve with conventional mammography, by utilizing X-ray refraction. This system is expected to achieve an approximately 1000-fold higher contrast and high spatial resolution at low dose; compared to techniques by use of X-ray absorption. Monochromatic ...
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Polybrominated Diphenylether Levels among United States Residents: Daily Intake and Risk of Harm to the Developing Brain and Reproductive Organs
Data on Polybrominated diphenylether (PBDE) concentrations in individual U.S. women were compiled. PBDE levels in adipose tissue, serum, and breast milk from individual U.S. women were found to follow similar lognormal distributions, which exhibited a high degree of variability. The distribution of lipid-normalized PBDE concentrations for all media combined had a median of 47.9 ng/g and a 95th ...
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A Detailed Introduction to Exosome Proteomics
What are exosomes? Exosomes, a tiny membrane vesicle with a lipid bilayer structure, are secreted by most cells and are approximately 40-200 nm in diameter. exosomes are found in body fluids, including blood, saliva, urine and breast milk. exosomes of different tissue origins differ in content composition and function, and this difference is dynamically regulated by the extracellular matrix and ...
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INOVIQ study validates the use of SubB2M as an aid in diagnosing malignant melanoma
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. SubB2M-based immunohistochemistry applications represent a new product opportunity for SubB2M in the $1.9b immunohistochemistry market. INOVIQ Ltd (ASX:IIQ) has successfully completed ...
By INOVIQ Ltd
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Reconstruction of tissues affected by Pilonidal Sinus Disease
Highlights • AROA’s Myriad Matrix™ is further validated in a clinical study and peer-reviewed publication in Journal of Wound Care. • Study of six patients shows 100% success rates from use of Myriad Matrix™ as an implant during surgical reconstruction of soft tissues affected by Pilonidal Sinus Disease (PSD). • All patients healed well with no major complications ...
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Pioneering VeraForm in Head and Neck Cancer Treatment: Sarcomatoid Carcinoma Tumor Bed Marking
Head and neck cancer surgery presents a number of unique challenges, not only for the surgeon but for the radiation oncologist who will subsequently treat those patients. Great care with an emphasis on precision must be taken to ensure that critical structures and tissues avoid collateral damage when possible. However, given the surgical site often lies in soft tissue, exact identification of the ...
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