cancer Articles
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Radiation-induced thyroid cancer: what we know and what we really understand
Results of the analysis of our own and literature data on the occurrence and development of radiation-induced thyroid cancer are presented. The analysis involved the distribution of the thyroid cancer incidence among 1 million children and 3 million adults, by age and sex, living in the radioactively contaminated territories of Russia; published data of the United Thyroid Cancer Registry of ...
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Low-dose irradiation for controlling prostate cancer
Prostate cancer is the second most commonly diagnosed cancer among North American men and the second leading cause of death in those aged 65 and over. The US Cancer Society recommends testing those over 50 years of age who are expected to live at least for 10 years, even though the ability of early detection to decrease prostate cancer mortality has not been demonstrated. A controversy exists ...
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A blood-based test that can detect cancer before its symptoms appear
AMADIX strongly believes that prevention is key to extend people’s life. In cancer, prevention is the best way to reduce the chances of having cancer. PREVECOLl® is an AMADIX’ blood-based test for colorectal cancer detection. Read the full new here ...
By Amadix
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Nanotechnology in cancer prevention, detection and treatment: bright future lies ahead
This paper is an overview of advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment. We begin with a brief description of the underlying causes of cancer. Then we address preventive treatment, disease-time treatment, and diagnosis in the context of some of the most recent advances in nanotechnology. Nanoparticle science is also briefly addressed as ...
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Transforming growth factor engages tace and erbb3 to activate pi3k/akt in erbb2-overexpressing breast cancer and desensitizes cells to trastuzumab
Departments of Cancer Biology, Medicine, Pathology, Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN; Expression Analysis, Durham, NC; Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, ...
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Identification of a posttranslational mechanism for the regulation of herg1 k+ channel expression and herg1 current density in tumor cells
A common feature of tumor cells is the aberrant expression of ion channels on their plasma membrane. The molecular mechanisms regulating ion channel expression in cancer cells are still poorly known. K+ channels that belong to the human ether-a-go-go-related gene 1 (herg1) family are frequently misexpressed in cancer cells compared to their healthy counterparts. We describe here a ...
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Presumption for selected cancers and occupation as a firefighter in Manitoba: the rationale for recent Canadian legislation on presumption
Provinces across Canada are suddenly considering or have already passed legislation establishing a rebuttable presumption for compensation for firefighters who develop certain types of cancer. This movement began in Manitoba and was motivated by appreciation of the role of firefighters in public safety. The evidentiary basis for establishing presumption for these cancers was developed in a report ...
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Defining Oncology and Aging
Cancer survival rates decrease with age, in part because the efficacy of cancer therapies declines in older individuals. Chemotherapy and radiotherapy wreak havoc on the immune system, kill both healthy and cancerous cells alike and cause a buildup of cellular waste in the tissue. This residual waste needs to be either removed from the body or efficiently restored to its original ...
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Evaluation of the dose and of the risk of cancer induction associated with the use of transmission X–ray body scanners using the Monte Carlo MCNPX code
In recent years, X–ray body scanners have been introduced at airports, penitentiaries and other places with considerable movement of people in order to combat drug trafficking, the entry of illegal materials and terrorism. However, although the application of this equipment in the national security area is indeed relevant, its use has caused a great deal of controversy, especially with regard to ...
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EMI-137: Intraoperative Imaging of Thyroid Cancer (NL)
Title: Detection of Thyroid Cancer and Central Lymph Node Metastases using c-Met Enhanced Optical Imaging Objective: The main objective of this phase I pilot study is to assess the feasibility of EMI-137 for the intraoperative detection of thyroid cancer and central lymph node metastases in PTC using optical fluorescent imaging Status: Study Completed Results: manuscript submitted for ...
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Addressing the cervical cancer burden in developing countries: Vietnam as a case study
Like most global diseases, the burden of the cervical cancer is borne primarily by women in less developed nations. In Vietnam, the government and certain private players are attempting to address the high mortality and morbidity rates of the disease. Vietnam promises to be an example of a relatively effective government approach for tackling cervical cancer that other similarly situated nations ...
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Institutional trust, information processing and perception of environmental cancer risk
This paper examines how institutional trust affects the way in which people process information and perceive risk. Data come from a study of risk perception in the circumstance of US state health department investigations of suspected cancer clusters, with 30 cases examined (n = 1,111). Trust is assessed for three information sources: state health departments, civic groups and industries involved ...
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ABS-INT-001 Internalizing Ab-ADC for Cancer Therapeutics - Case Study
Background Growth factor X is a well-characterized target that is involved in multiple proliferation-related signal transduction pathways Growth factor X expressed in multiple cancer types and therefore is an ideal target cancer therapies ...
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Ionising radiation and the health of nuclear industry workers
The data on deaths from all causes and cancers among workers in the nuclear industry are considered in the light of the data published by the International Agency for Research on Cancer (IARC) in 2007 (Vrijheid et al., 2007; Thierry-Chef et al., 2007; Cardis et al., 2007). The dose-effect relationship is assumed to be linear with an arbitrary sign of the slope. A zero effect of the dose is also ...
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Cancer incidence in areas with elevated levels of natural radiation
It has been reported that on reaching a certain level of cell damage the production of repair enzymes is triggered which decreases the chromosome aberrations. If this happens, prolonged exposure to high levels of natural radiation in areas with elevated levels of background radiation could decrease the frequency of chromosome aberrations. Recent epidemiological studies indicated that there is an ...
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A survivin-ran complex regulates spindle formation in tumor cells
Aberrant cell division is a hallmark of cancer, but the molecular circuitries of this process in tumor cells are not well understood. Here, we used a high-throughput proteomics screening to identify novel molecular partners of survivin, an essential regulator of mitosis overexpressed in cancer. We found that survivin associates with the small GTPase Ran in an evolutionarily conserved recognition ...
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Infiltrating Ductal Carcinoma (IDC) - Case Study
Patient with positive family history of breast cancer and ovarian cancer. September 2003 mammogram reported benign micro calcifications. August 2007 patient presented with a palpable mass in lateral aspect of left ...
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Improved health from Chernobyl
High and low dose irradiation elicit opposite results. Irrefutable evidence from three arenas provides ample evidence that low-dose irradiation improves health: 1) generations living in high levels of ambient radiation, 2) accidentally exposed nuclear workers, 3) Japanese atomic bomb victims. Since most exposures to ionising radiation at Chernobyl were less than 20 cGy, the concept predicts that ...
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Risk analysis of thyroid cancer incidence after exposure in childhood in the most contaminated areas of Ukraine, Belarus, and Russia in comparison with other studies
The current knowledge about thyroid cancer induction due to 131I exposures during childhood is limited. Due to the low incidences observed, it was assumed that 131I is less effective in cancer induction by a factor of 3, if compared to external exposures. An increase of the thyroid cancer incidence among children and adolescents from the south-eastern Belorussian, the northern Ukrainian, and the ...
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Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate
T-47D human breast cancer cells were irradiated with 60Co γ-radiation and radiation response was measured by loss of ability of single-cells to form colonies. The influence of the dose-rate on the ability of priming irradiation to abolish Low-Dose Hyper-Radiosensitivity (LDHRS) was investigated. In agreement with previous reports, the LDHRS was abolished by an acute priming dose of 0.3 Gy given 6 ...
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