cancer associated Articles
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Advancing Cancer Treatments with ALZET Osmotic Pumps
The research summarized in this whitepaper provides a number of examples of how ALZET® pumps offer a superior pre-clinical drug dosing option for the delivery of a wide array of anti-cancer agents, including small molecules, immunotherapies, radiotherapies, combination treatments, and novel drug entities. This whitepaper also explores how ALZET® pumps have been used to successfully test ...
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Evaluation of the dose and of the risk of cancer induction associated with the use of transmission X–ray body scanners using the Monte Carlo MCNPX code
In recent years, X–ray body scanners have been introduced at airports, penitentiaries and other places with considerable movement of people in order to combat drug trafficking, the entry of illegal materials and terrorism. However, although the application of this equipment in the national security area is indeed relevant, its use has caused a great deal of controversy, especially with regard to ...
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Environmental Policies to Reduce Cancer Risk
Untitled Document Cancer is the second most prevalent cause of death in the United States, behind heart diseases. The lifetime risk of contracting cancer is roughly 1 in 3 for women and 1 in 2 for men. It is therefore not surprising that U.S. legislators and policy-makers continue to seek avenues for addressing cancer risks attributable to environmental ...
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Mechanisms underlying the conversion of DNA double-strand breaks into chromatid breaks
Chromatid breaks are associated with cancer-predisposition but may also provide a mechanism of radiation carcinogenesis via the formation of genomic rearrangements. A model of chromatid breakage has been proposed and supporting evidence presented which derives from work with a genetically-engineered hamster cell line containing a unique dsb site. Chromatid breaks are induced in irradiated ...
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CD Genomics Perspective: The Application of RNA-Seq and DNA-Seq in Cancer Research
Clinicians can make better diagnostic and treatment decisions using the data obtained by next-generation sequencing (NGS) technologies. Breast cancers, for example, have typically been diagnosed using mammography, physical exam, and histology. Genetics became more significant after the discoveries of oncogenes and other biomarkers. Today, commercially available microarray-based tests enable more ...
By CD Genomics
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Regulation of cancer by therapeutic vaccination and dietary bio-modulation involving organ-specific mitochondria
Cancer therapy should aim to prevent recurrent disease. Surgery and toxic treatments remove only symptoms associated with cancer without trying to intervene in the aetiology, therefore the disease may recur. The autologous cancer vaccine supplemented with bio-modulation might fulfil requirements for effective tumour therapy. The autologous tumour vaccine is formed in the same way as our bodily ...
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Antibody-peptide epitope conjugate (APEC), another disguise for ADC
Background Tumor immunotherapies compose immune checkpoint inhibitors, therapeutic antibodies, tumor vaccines, cellular therapies, and so on. However, each has its own set of issues, such as the fact that CAR-T therapy is an individual therapy that is costly; immune checkpoint inhibitors are highly effective, but only in some patients. The researchers expose us to a radically different way of ...
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CD Genomics Perspective: High-Throughput Sequencing Approach to Explore the Human Microbiome
The Use of Microbiome Sequencing in Cancer Research A growing body of evidence now suggests that human microbial dysbiosis has a crucial role in cancer development and progression. Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of ...
By CD Genomics
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Delivering a precision medicine programme at scale
The Covid-19 pandemic highlighted the disparity between those who succumbed to severe illness while others remained relatively unaffected, underscoring the urgent need to shift the healthcare industry’s focus from a one-size-fits-all approach to more personalised healthcare. Personalised medicine promises to transform healthcare with treatments tailored to a patient’s unique genetic ...
By Lifebit
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Abstract 4842: A comparative preclinical study of PARP inhibitors demonstrates superb properties for IDX-1197
Abstract Background PARP inhibitors have demonstrated clinically meaningful increase in progression-free survival as a single agent in women with recurrent ovarian cancer following a response to platinum-based chemotherapy. We aimed to develop a novel PARP inhibitor that may have potent antitumor efficacy. IDX-1197 is a novel, potent, selective, and orally bioavailable poly (ADP-ribose) ...
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Unveiling Gene Isoforms by RNA Sequencing: Detection Methods and Applications
What Is Gene Isoform? Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their coding sequence or in the regulatory elements that control their expression. Alternative splicing is a process in which ...
By CD Genomics
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Fatty Acids in Cancer
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. And the activation of ab initio synthesis is negatively ...
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VisionGate’s Breakthrough Lung Cancer Detection Technologies Help Save Lives
VisionGate’s Non-Intrusive Testing, Patented Cell-CT Imaging and AI-Powered Cancer Detection Work Together to Deliver Early Detection of Lung Cancer. VisionGate’s mission is backed by cutting-edge technology that is designed to save lives through early detection and prevention of lung cancer. VisionGate’s breakthrough technologies include non-intrusive testing, 3D cell imaging ...
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Cancer, Sarcoid, or Rose Thorn Infection? - Case Study
This case study highlights medical calculators and analytics which can be instrumental in a physician’s clinical decision making process, especially when the diagnosis can be complicated due to the patient’s prior health conditions. Mary is a 66-year-old retired nurse. Five years ago she had been diagnosed with an adenocarcinoma that involved her right pleural space. An extensive ...
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Many Faces of Sepsis (1): Cancer Therapy and Management Febrile Neutropenia - Case Study
The purpose of this case study is to highlight ways in which medical algorithms can be integrated into the clinical decision making process. This case study is the first of a series focused on sepsis, a common but complex clinical problem. Use of algorithms can help healthcare providers diagnose sepsis early. Throughout our discussion, appropriate algorithms are suggested to help clinicians ...
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Proteomics and the development of precision medicines against cancer (Part 1)
Cancer is a heterogenous mixture of diseases characterized by, among other things, the abnormal, uncontrolled growth of cells derived from otherwise healthy tissues (Hanahan 2022). Although cancer cells sometimes grow into balls of cells and stop there (so-called benign tumors), often they gain the ability to disperse throughout the body, seed the growth of other tumors, disrupt the function of a ...
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A survivin-ran complex regulates spindle formation in tumor cells
Aberrant cell division is a hallmark of cancer, but the molecular circuitries of this process in tumor cells are not well understood. Here, we used a high-throughput proteomics screening to identify novel molecular partners of survivin, an essential regulator of mitosis overexpressed in cancer. We found that survivin associates with the small GTPase Ran in an evolutionarily conserved recognition ...
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Development of a System for the Early Diagnosis of Breast Cancer
We are now developing a system which allows the visualization of the structure and tissue associated with breast cancer, which is difficult to achieve with conventional mammography, by utilizing X-ray refraction. This system is expected to achieve an approximately 1000-fold higher contrast and high spatial resolution at low dose; compared to techniques by use of X-ray absorption. Monochromatic ...
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Mesothelin: A New Target for Cancer Therapy
Structure and function of mesothelin The MSLN gene is located in chromosome 16p13. It contains 17 exons, with a cDNA length of about 2138bp, has a 1884-bp open reading frame, and encodes the precursor protein of 628 amino acids (69 kDa). This precursor protein can be hydrolyzed by furin protease into two parts: mesothelin in the size of 40 kDa fragments and 31 kDa secreted fragments called ...
By BOC Sciences
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Cancer Target: Mesothelin
Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. Its biological function has not yet been clarified, but due to its limited distribution in normal tissues and high expression in some tumor tissues, it is expected to be used in tumor-specific treatment. In existing studies of human epidermoid carcinoma cell lines expressing mesothelin, biodistribution analysis ...
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