cancer based Articles
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Beyond Just Peptide Antigens: The complex world of peptide-based cancer vaccines
Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? What other factors such as adjuvants etc should be considered? Can Immunol oncological agents be synergetic with peptide vaccines? Read the full article: Beyond Just Peptide Antigens: The complex world of ...
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Neutron capture therapy at the MEPhI reactor
The article discusses the results of the creation and development of the irradiation base for Neutron Capture Therapy (NCT) at the MEPhI Reactor, development and studies of boron- and gadolinium-containing compounds, and presents the results of pre-clinical NCT studies in large laboratory animals – dogs with spontaneous melanoma.Keywords: nuclear reactors, neutron capture therapy, melanoma, boron ...
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Nanotechnology in cancer prevention, detection and treatment: bright future lies ahead
This paper is an overview of advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment. We begin with a brief description of the underlying causes of cancer. Then we address preventive treatment, disease-time treatment, and diagnosis in the context of some of the most recent advances in nanotechnology. Nanoparticle science is also briefly addressed as ...
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INOVIQ (ASX:IIQ) signs agreement with Nicoya Lifesciences to develop SubB2M-based test
INOVIQ (IIQ) signs a contract research agreement with Nicoya Lifesciences to develop a SubB2M-based test that uses its Alto digital surface plasmon resonance (SPR) platform The company believes a SubB2M-based SPR test has the potential to be developed as a multi-cancer detection test that first detects the Neu5Gc cancer signal Under the agreement, INOVIQ will pay an agreed cost for the work ...
By INOVIQ Ltd
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Spanish Cancer Company Universal Dx to Commercialize Methylation Method for Lung Cancer Detection
NEW YORK - Spanish cancer research firm Universal Diagnostics is gearing up to commercialize a liquid biopsy test that applies methylation biomarkers to detect lung cancer, based on data presented at the International Association for the Study of Lung Cancer 2020 World Conference for Lung Cancer (WCLC) last month. The Seville-based firm also expects to release clinical data on its next ...
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Novel nanoplatform for oral delivery of anti–cancer biomacromolecules
Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechnology promises the new hope and offers advantages such as controlled release, target specific delivery, combinatorial therapy and many more. In this study, we demonstrate the formulation of a novel alginate enclosed, chitosan ...
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Synthesis and characterisation of new designed protoporphyrin-stabilised gold nanoparticles for cancer cells nanotechnology-based targeting
Nanotechnology has entered the field of medicine in recent dacades and especially, in drug delivery systems, nanoparticles have shown an ability to improve pharmacokinetics, pharmacodynamics, efficacy and to reduce the toxicity of associated drugs. In this study, we have designed a new protoporphyrin-conjugated gold nanoparticle to selectively target and photo- or sonodynamic therapy of tumoural ...
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Mapk4 May Be a New Target for the Treatment of Triple-Negative Breast Cancer
There is now growing evidence that the MAPK4 enzyme may be involved in cancer growth and resistance to specific therapies. Recently, an article titled " MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade" was published in Nature Communications. By analyzing public genome databases, the researchers found that a large number of triple-negative ...
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Acibadem Hospitals Digital Pathology Project - Case study
Virasoft provides digital pathology systems that optimize the pathology workflow with digital slide management, slide viewing and quantitative image analysis for Acibadem Hospitals pathology laboratories. In partnership with Acibadem Hospitals and Virasoft, artificial intelligence projects are being developed for several cancer diagnosis. Digital Pathology System ViraCenter is an integrated ...
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New blood-based CRC test is more than 90% accurate, study says
A study of Universal Diagnostics' blood-based colorectal cancer test found it was more than 90 percent accurate, the company announced June 3. The blood test was found to detect colorectal cancer with 92 percent sensitivity and 97 percent specificity. It also was shown to have 89 percent sensitivity and 97 percent specificity detecting early-stage cancer. The test uses single target sequence ...
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Science: A protein-protein interaction map of breast cancer constructed
Advances in DNA sequencing technology have made it possible to extensively analyze the breast tumor genome and construct a catalog of gene mutations that may initiate or drive tumor progression. In addition to the well-known common mutations in oncogenes (such as TP53 and PIK3CA), breast cancer also contains a variety of rare mutations that have a low incidence in the patient population. Despite ...
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Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines
From the eradication of smallpox through to the global response to the COVID-19 pandemic, vaccines have been a cornerstone in the fight against infectious diseases in humans and livestock since the 18th century. Although vaccines against COVID-19 are unlikely to eradicate the disease in the way that the smallpox vaccine did, they have proved very effective in preventing death and hospitalisation, ...
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The Future of Hydrocolloids: Innovations in New Applications
What Is Hydrocolloid? Hydrocolloids are molecules that have a high affinity for water and can form thick gels in water. Hydrocolloids can be derived from various natural sources such as plants (e.g. pectin, guar gum), animals (e.g. gelatin), and microbial sources (e.g. xanthan gum). They can also be modified chemically to suit specific applications. Hydrocolloids are used in a wide variety of ...
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ADC Drugs For HER2 Positive Breast Cancer
According to the latest data, breast cancer has overtaken lung cancer to become the most common cancer among women, and the death rate is the second highest among female tumors, seriously affecting the physical and mental health of women around the world. Patients with abnormal expression of human epidermal growth factor receptor (HER2) account for 15%-20% of all breast cancers, which is highly ...
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These ML-powered startups are the top 30 shortlisted in the ML Elevate program
Close to 200 machine learning-powered startups applied to the ML Elevate programme, hosted by YourStory and AWS in association with Intel and Nexus Venture Partners, when it was first launched in October 2020. Early-stage startups on the lookout for a combination of tools, resources and insights necessary to build,grow and scale their startup to new heights formed the majority of applicants to ...
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What Are Heparins?
Heparin, also known as standard heparin or unfractionated heparin, is a linear polysaccharide consisting of 1-4 linked disaccharide repeat units of uronic acid and glucosamine residues. Heparin was discovered nearly 100 years ago and has been used clinically as a blood anticoagulant since 1935. This is due to its ability to bind to the antithrombin(serine protease inhibitor), causing the ...
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CD Genomics Perspective: The Application of RNA-Seq and DNA-Seq in Cancer Research
Clinicians can make better diagnostic and treatment decisions using the data obtained by next-generation sequencing (NGS) technologies. Breast cancers, for example, have typically been diagnosed using mammography, physical exam, and histology. Genetics became more significant after the discoveries of oncogenes and other biomarkers. Today, commercially available microarray-based tests enable more ...
By CD Genomics
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Advantages of using Spine 3D(CT-based) Navigation in complex Spine Surgeries
To confidently perform a spinal fusion and screw fixation with excellence surgical navigation is consistently used as a powerful tool. Surgical Navigation provides real-time guidance and precise measurements for accurately placing the pedicle screws to help stabilize the spine. A preoperative CT scan gives a detailed visualization of the structure decreasing the potential for implant-related ...
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The Liposome-Based PROTAC Strategy
Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system exhibits selective degradation of target proteins, with folate serving as a key ligand. In this study, the ...
By BOC Sciences
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Exploring the Potential of RNA-Seq in Various Fields
What is RNA-Seq? Regulation of gene expression is fundamental to linking genotypes with phenotypes. RNAs shape complex gene expression networks, which drive biological processes. An in-depth understanding of the underlying mechanisms of how to govern these complex gene expression networks is vital for the treatment of complex diseases such as cancer. Hybridization-based microarrays are used to ...
By CD Genomics
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