cancer development Articles
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A new approach to individual prognostication of cancer development under conditions of chronic radiation exposure
This paper describes a new approach to modelling carcinogenesis, including that induced by ionising radiation. The specific feature of the developed approach is that the model, still adhering to the mutational theory of carcinogenesis, includes parameters of intracellular processes which can be measured for any individual. The assumptions laying the basis for this approach are that cell ...
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Addressing the cervical cancer burden in developing countries: Vietnam as a case study
Like most global diseases, the burden of the cervical cancer is borne primarily by women in less developed nations. In Vietnam, the government and certain private players are attempting to address the high mortality and morbidity rates of the disease. Vietnam promises to be an example of a relatively effective government approach for tackling cervical cancer that other similarly situated nations ...
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Chronic cadmium exposure promotes nasopharyngeal carcinoma
Chronic cadmium exposure promotes nasopharyngeal carcinoma progression and radioresistance Dr Lin Peng and her team investigate how environmental pollutant exposure influences the risk of cancer development and therapeutic resistance at the Department of Laboratory Medicine, Cancer Hospital of Shantou University Medical College, ...
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Presumption for selected cancers and occupation as a firefighter in Manitoba: the rationale for recent Canadian legislation on presumption
Provinces across Canada are suddenly considering or have already passed legislation establishing a rebuttable presumption for compensation for firefighters who develop certain types of cancer. This movement began in Manitoba and was motivated by appreciation of the role of firefighters in public safety. The evidentiary basis for establishing presumption for these cancers was developed in a report ...
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Evaluation of radioinduced damage and repair capacity in human breast cancer cells, MCF-7 and T-47D
Ionising radiation is an established etiological agent for breast cancer, but is also a therapeutic modality used in cancer treatment. The accumulation of deoxyribonucleic acid (DNA) damage and deficient DNA repair are considered susceptibility factors that predispose individuals to breast cancer development. In the present study, the genetic damage induced by gamma radiation and repair capacity ...
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New blood-based CRC test is more than 90% accurate, study says
A study of Universal Diagnostics' blood-based colorectal cancer test found it was more than 90 percent accurate, the company announced June 3. The blood test was found to detect colorectal cancer with 92 percent sensitivity and 97 percent specificity. It also was shown to have 89 percent sensitivity and 97 percent specificity detecting early-stage cancer. The test uses single target sequence ...
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HPV-16 E7-Specific Cellular Immune Response
HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in ...
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Inflammation, Immunity and Cancer
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune ...
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Revealing the molecular mechanism of mutant protein-induced melanoma in the body
The RNA surveillance pathway detects and interprets defective transcripts to ensure RNA fidelity. Recently, in a research report entitled "Oncogenic CDK13 mutations impede nuclear RNA surveillance" published in Science, scientists from Howard Hughes Medical Institute and other institutions discovered a new type of mechanism that affects the occurrence of melanoma, providing broad and important ...
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Data and literature gathering in chemical cancer risk assessment
In recent years, chemical cancer risk assessment has faced major challenges: the demand for cancer risk assessment has grown considerably with strict legislation regarding chemical safety, whereas cancer hazard identification has turned increasingly complex due to the rapid development and high publication rate in biomedical sciences. Thus, much of the scientific evidence required for hazard ...
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The C-Myc Oncogene Is Associated with Aging, New Study Found
The Myc gene is one of the most important drivers of cancer in mice and humans. Myc also plays a newly discovered key role in aging, according to a new study in Cell Reports by researchers at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine. The study, led by Edward V. Prochownik, MD, UPMC Children's Hematology/Oncology Division and Paul C. Gaffney ...
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CD Genomics Perspective: High-Throughput Sequencing Approach to Explore the Human Microbiome
The Use of Microbiome Sequencing in Cancer Research A growing body of evidence now suggests that human microbial dysbiosis has a crucial role in cancer development and progression. Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of ...
By CD Genomics
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Gold nanoparticle–based platforms as cancer–targeted molecules delivery systems
Cancer is a major cause of deaths. More recently, drug delivery systems (DDSs) using gold nanoparticles (GNPs) have been widely developed in cancer therapy for their easily synthesised, functionalised, better biocompatible, and low toxicity properties. Gold nanoparticle–based platforms as cancer–targeted molecules delivery to tumour tissues have been proposed as an effective strategy by ...
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A Bayesian design for phase I cancer therapeutic vaccine trials
Abstract Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not ...
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Vision-based 3D surface motion capture for the DIET breast cancer screening system
Breast cancer is one of the most prevalent forms of cancer in the world today. The search for effective treatment and screening methods is a highly active area of research. The Digital Image-based Elasto-Tomography (DIET) project is a new breast cancer screening system under development, where surface motion from the mechanically actuated breast is measured in 3D, and used as input to an inverse ...
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What is the reliability of chromosomal aberration assays as biomarkers of individual sensitivity towards ionising radiation?
The development of biomarkers of susceptibility or sensitivity towards ionising radiation is important for the identification of individuals who may be at increased risk for the development of cancer after occupational, environmental or medical exposures. In this study we investigated the inter- and intra-individual variation of the MN assay and the G2 assay in irradiated lymphocytes to assess ...
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Myths vs Facts: HPV and Cervical Cancer
Cervical cancer is the second most common cancer affecting and causing deaths among women in India. Cervical cancer is caused by the Human Papilloma Virus or HPV. The lower part of the uterus known as Cervix is affected due to HPV infection. This cancer develops very slowly and most of the times is asymptomatic during the development stage. HPV infection is a sexually transmitted infection (STI) ...
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Ozette’s computationally-driven analysis aids advancement of cancer drug development - Case study
Summary Inflammation is a hallmark of the tumor microenvironment and an area of active investigation. To better understand how tumor inflammation differs from general inflammation, such as in gum disease, Drs. Prilic, Mair, and Erikson employed novel methods, which included high parameter flow cytometry and Ozette’s foundational technology–full annotation using ...
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Regenerative medicine: new opportunities for developing countries
There has been a major shift in burden of disease in developing countries. Although traditionally associated with industrialised nations, epidemic levels of non-communicable diseases, such as diabetes, cardiovascular diseases and cancer, now threaten the developing world and are straining health systems that are still struggling with persisting levels of infectious disease. Developing countries ...
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Introduction to Protein N-glycosylation
Glycosylation is one of the most important protein post-translational modifications in organisms, occurring in 50%-70% of proteins in cells. It is associated with many diseases as it can affect essential life activities, such as cell recognition, differentiation, adhesion, signal transduction, and immune response. Immune diseases, congenital sugar defects, and dozens of genetic diseases, as well ...
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