cancer radiotherapy Articles
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Low doses of γ–radiation induce consistent protein expression changes in human leukocytes
Twenty percent of cancer patients experience adverse effects after radiotherapy. The therapeutic doses are adjusted to the most sensitive individuals, resulting in a suboptimal dose for many patients. At present there is no screening system available to predict individual radiosensitivity. The main aim of this study is to investigate differences in protein expression pathways induced by low doses ...
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Development of an in vivo assay for detection of non-targeted radiation effects
An adaptive response may be defined as the effect of a small priming dose of radiation modifying the anticipated cellular response of the same tissues so as to alter the predicted response to a larger dose of radiation. We and many others have demonstrated that at low radiation doses (less than 0.5 Gy) the lethal and mutational effect of the radiation is mainly, possibly entirely, due to the ...
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The Promoter of Life Evolution—Superoxide Dismutase
More and more scientific evidence shows that reactive oxygen species (ROS) and reactive nitrogen species are important mediators of signaling events in cells, especially the superoxide anion in reactive oxygen species. If the content of superoxide anion in the human body is too high, it may induce various diseases, including pro-inflammatory diseases (pro-inflammatory diseases), cardiovascular ...
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Advancing Cancer Treatments with ALZET Osmotic Pumps
The research summarized in this whitepaper provides a number of examples of how ALZET® pumps offer a superior pre-clinical drug dosing option for the delivery of a wide array of anti-cancer agents, including small molecules, immunotherapies, radiotherapies, combination treatments, and novel drug entities. This whitepaper also explores how ALZET® pumps have been used to successfully test ...
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Link Between Periodontal Disease and Oral Cancer
There is a strong relationship between periodontal disease and oral cancer. In patients with tongue cancer, the periodontal disease preceded the tongue cancer. Although periodontal disease and oral cancers are both located in the mouth, until recently, there was never thought to be a connection between the two. New evidence is coming to light to show that those with periodontal disease increase ...
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The development of an anthropomorphic and anthropometric thorax female phantom for experimental radiodosimentry
Anthropomorphic-anthropometrical phantoms are simulator objects for measuring absorbed dose in conditions equivalent to those found in the exposure of the internal organs to charged particles, photons or neutrons generated by external beams or to internal intake of radioisotopes. This paper addresses the construction of an anatomical simulator that retains the anthropomorphic and anthropometrical ...
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Institute of Cancer Research Makes Groundbreaking Treatment Discoveries With NM30LA - Case Study
The Institute of Cancer Research or ICR, is a world leading institution in cancer gene discovery, cancer drugs and innovations in radiotherapy. With the help of Peak's NM30LA gas generator ICR have managed to streamline their workflow. Name: Amin Mirza Job title: Head of Structural Chemistry Company: Institute of Cancer Research Location: London, UK One of ICR’s main priorities is to ...
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Expression Genomics of Cervical Cancer: Molecular Classification and Prediction of Radiotherapy Response by DNA Microarray
Purpose The incidence and mortality rates of cervical cancer are declining in the United States; however, worldwide, cervical cancer is still one of the leading causes of death in women, second only to breast cancer. This disparity is at least partially explained by the absence of or comparatively ineffective screening programs in the developing world. Recent advances in expression genomics have ...
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