cancer research Articles
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AST 250kg load cell and cancer research
A study was approved by The University of Western Sydney Human Research Ethics to determine whether resistance training improves fatigue and quality of life in previously inactive breast cancer survivors. Upper body strength was measured by the force output during a unilateral isometric chest press. The force was measured using our AST 250kg Load Cell. The study found that 16 weeks of ...
By PT Limited
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Transforming growth factor engages tace and erbb3 to activate pi3k/akt in erbb2-overexpressing breast cancer and desensitizes cells to trastuzumab
Departments of Cancer Biology, Medicine, Pathology, Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN; Expression Analysis, Durham, NC; Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, ...
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The histone demethylase kdm5b/jarid1b plays a role in cell fate decisions by blocking terminal differentiation
Stem Cell and Cancer Research Institute, McMaster University Hamilton, CA L8N 3G5; Department of Biochemistry and Biomedical sciences, Faculty of Health Sciences, McMaster University, Hamilton, CA L8N 3G5; Kings College Medical School, Breast Cancer Biology Lab, 3rd floor Thomas Guy House, Guys Hospital, London SE1 ...
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New Breakthrough in Cancer Cell Research
The body's immune system is an effective weapon against disease, and immunotherapy of cancer cell research is the current frontier in the treatment of cancer and other diseases. Recently, researchers at Notre Dame University have identified specific features of the reaction of two distinct peptide antigens to a T-cell receptor (TCR), which provides new clues to optimizing molecular structure ...
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Institute of Cancer Research Makes Groundbreaking Treatment Discoveries With NM30LA - Case Study
The Institute of Cancer Research or ICR, is a world leading institution in cancer gene discovery, cancer drugs and innovations in radiotherapy. With the help of Peak's NM30LA gas generator ICR have managed to streamline their workflow. Name: Amin Mirza Job title: Head of Structural Chemistry Company: Institute of Cancer Research Location: London, UK One of ICR’s main priorities is to ...
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Matrix Gemini Lims at work in Cancer research trials case study
Executive Summary The Roy Castle Lung Cancer Foundation (RCLCF) is a UK wide charity, dedicated to the defeat of lung cancer. It funds basic science research, tobacco control initiatives and work in lung cancer patient information, support and advocacy. RCLCF works towards defeating lung cancer through research, campaigning and education and gives practical and emotional support for patients and ...
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CD Genomics Supports Immune and Cancer Research with TCR-Seq Service
CD Genomics is a world-leading genomics services company that continues to innovate in high throughput sequencing services for the genomics industry, as well as genotyping, bioinformatics, microarrays, and more. The company has recently launched TCR-seq, a powerful service that enables rapid and efficient analysis of T-cell receptor (TCR) diversity and clonality, providing critical support for ...
By CD Genomics
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The Limitations and Challenges of Cancer Therapies
Considerable investment into cancer research has led to the development of remarkable new therapies, which have greatly improved therapeutic outcome for the countless individuals diagnosed with cancer. Until recently, almost all therapies that were granted clinical approval were small molecules. However, biotechnological advances in the last several decades have made it possible to develop ...
By Indee Labs
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CD Genomics Perspective: NGS-Based Gene Panels for Cancer Research
IntroductionTumorigenesis involves in many somatic mutations, most of which are random. Generally, hundreds of genes are thought to be associated with oncogenesis progression and have high mutation rates. Digging deeper into the cancer genome can help to understand the molecular mechanisms of tumorigenesis and provide guidance for the prevention, treatment and prognosis strategies. The main ...
By CD Genomics
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Mapk4 May Be a New Target for the Treatment of Triple-Negative Breast Cancer
There is now growing evidence that the MAPK4 enzyme may be involved in cancer growth and resistance to specific therapies. Recently, an article titled " MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade" was published in Nature Communications. By analyzing public genome databases, the researchers found that a large number of triple-negative ...
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A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia (Clinical Cancer Research)
Purpose:Although considerable progress has been made withautologous T cell–based therapy in B-cell malignancies, appli-cation in chronic lymphocytic leukemia (CLL) lags behind dueto disappointing response rates as well as substantial toxicitythat is of particular concern in the elderly CLL population.Vg9Vd2-T cells form a conserved T-cell subset with strongintrinsic immunotherapeutic ...
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Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
By CD Genomics
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The Francis Crick Institute CHP Plant - Case Study
The Francis Crick institute is being built in central London next to St Pancras International station. By bringing together scientists from all disciplines, it will not only help to improve people's lives but will also keep the UK at the forefront of innovation in medical and bioscience research, attract high-value investment, and strengthen the economy. Francis Crick was one of Britain’s ...
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A brief overview of the research reactor FRM II
The research reactor Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II) is operated using a single compact fuel element embedded in a large heavy water filled moderator tank. Consequently the thermal neutron flux density exhibits its maximum value outside the fuel element in an area which is accessible for experimental installations. A further advantage of the use of heavy water is that it ...
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CD Genomics Perspective: The Application of RNA-Seq and DNA-Seq in Cancer Research
Clinicians can make better diagnostic and treatment decisions using the data obtained by next-generation sequencing (NGS) technologies. Breast cancers, for example, have typically been diagnosed using mammography, physical exam, and histology. Genetics became more significant after the discoveries of oncogenes and other biomarkers. Today, commercially available microarray-based tests enable more ...
By CD Genomics
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Nanostics Re-Opens ClarityDX Prostate Clinical Study with New US Recruitment Site
Summary Nanostics' clinical validation study for ClarityDX Prostate, a liquid biopsy test for the early diagnosis of clinically significant prostate cancer, re-opens recruitment after lifting of COVID-19 research restrictions A top-ranked research institute in the Northeast US will now partner with Nanostics' by recruiting patients for the clinical validation study This partnership will ...
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Nanostics Announces Study Data Supporting ClarityDX Prostate as a Reflex Test to Predict Clinically Significant Prostate Cancer
Real-world data shows that at a 94% sensitivity level for prostate cancer ClarityDX Prostate® is 147% more specific than the PSA test for predicting clinically significant prostate cancer. Using ClarityDX Prostate® as a reflex test vs. PSA test alone could have resulted in 37% fewer unnecessary biopsies. The clinical study recruited men from two sites in Alberta, Canada, and one site ...
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Understanding Drug-Disease Relationship Analysis: A Key to Drug Discovery
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
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Universal Diagnostics - Case Study
Name: Paola Hurtado Job Title: Laboratory Director Company: Universal Diagnostics, Spain Infinity supplies LC-MS used in early detection Universal Diagnostics is a biomedicine start-up focused on the development of cutting-edge technologies in metabolomics, genetics and bioinformatics, with the mission to develop a blood test for early detection. Based on proprietary technologies and ...
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If cloning is the answer, what was the question? Power and decision-making in the geneticization of health
Since the announcement of the birth of Dolly the cloned sheep in February 1997, assiduous attempts have been made to emphasise the potential benefits of human cloning techniques that do not result in a cloned baby: replacement body organs; cancer and ageing research; testing new pharmaceuticals, to name a few. Such research would nonetheless pave the way for the replication of humans and for ...
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