cancer treatment Articles
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Nanodrug potential in cancer therapy: efficacy/toxicity studies in cancer cells
The interest of nanotechnology to find a more effective approach for drug delivery is growing fast. Nanoparticles as drug vehicles potentially improve the pharmacokinetic and pharmacodynamic properties of various types of drugs, and provide a tool to visualise molecules and tumour target cells that otherwise cannot be detected through conventional imaging. However, there are many aspects of ...
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Chromosomal aberrations induced by a low dose of neutron irradiation and hyperthermia
The purpose of this study was to investigate the effect of Hyperthermia (HT) on the Frequency of Chromosomal Aberrations (FCA) induced by a low dose of neutron irradiation. Blood samples were exposed to HT, 6cGy neutrons, HT + neutrons and neutrons + HT, and the FCA was scored in metaphase. HT alone at 41.5°C had no effect on FCA; however, the FCA was significantly higher at 43°C (p Keywords: low ...
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Advancing Cancer Treatments with ALZET Osmotic Pumps
The research summarized in this whitepaper provides a number of examples of how ALZET® pumps offer a superior pre-clinical drug dosing option for the delivery of a wide array of anti-cancer agents, including small molecules, immunotherapies, radiotherapies, combination treatments, and novel drug entities. This whitepaper also explores how ALZET® pumps have been used to successfully test ...
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Nanotechnology in cancer prevention, detection and treatment: bright future lies ahead
This paper is an overview of advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment. We begin with a brief description of the underlying causes of cancer. Then we address preventive treatment, disease-time treatment, and diagnosis in the context of some of the most recent advances in nanotechnology. Nanoparticle science is also briefly addressed as ...
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Beyond Just Peptide Antigens: The complex world of peptide-based cancer vaccines
Therapeutic vaccines may well be the next wave of immunotherapy for cancer treatment. Peptide-based vaccines will play a pivotal role in the field. How is a peptide vaccine designed? What other factors such as adjuvants etc should be considered? Can Immunol oncological agents be synergetic with peptide vaccines? Read the full article: Beyond Just Peptide Antigens: The complex world of ...
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Evaluation of radioinduced damage and repair capacity in human breast cancer cells, MCF-7 and T-47D
Ionising radiation is an established etiological agent for breast cancer, but is also a therapeutic modality used in cancer treatment. The accumulation of deoxyribonucleic acid (DNA) damage and deficient DNA repair are considered susceptibility factors that predispose individuals to breast cancer development. In the present study, the genetic damage induced by gamma radiation and repair capacity ...
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Defining Oncology and Aging
Cancer survival rates decrease with age, in part because the efficacy of cancer therapies declines in older individuals. Chemotherapy and radiotherapy wreak havoc on the immune system, kill both healthy and cancerous cells alike and cause a buildup of cellular waste in the tissue. This residual waste needs to be either removed from the body or efficiently restored to its original ...
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Gold nanoparticle–based platforms as cancer–targeted molecules delivery systems
Cancer is a major cause of deaths. More recently, drug delivery systems (DDSs) using gold nanoparticles (GNPs) have been widely developed in cancer therapy for their easily synthesised, functionalised, better biocompatible, and low toxicity properties. Gold nanoparticle–based platforms as cancer–targeted molecules delivery to tumour tissues have been proposed as an effective strategy by ...
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Clinical significance of low-dose radiation therapy: radiation hormesis
This study was designed to investigate the clinical significance of low-dose radiation therapy, radiation hormesis, and accuracy of therapeutic regimen. Radiation hormesis was performed in six patients (four patients with malignant diseases and two patients with benign diseases) in the experimental room where they could be exposed to a low level of direct gamma ray and inhale radon gas ...
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Immune Strategies for Cancer Treatment
In the search for innovative and effective ways to target cancer, we are faced with more than just a challenging problem; we are faced with our own cells as opponents. Cancer cells evolve to achieve an optimum of physical fitness, giving them an array of abilities that no cell should possess in a healthy organism. One way to find novel therapies against cancer therefore could imply finding a ...
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The development of complete personalized treatment plans for colon cancer patients utilizing three gene prediction models.
Background Combination chemotherapy using fluorouracil, leucovorin with or without oxaliplatin (5-FU and FOLFOX) are standard treatment for locally advanced colon cancer. However, about half of the patients developed recurrence. The objective of this study was to use gene profiling to predict treatment efficacy for colon cancer patients (stages 1-3). We developed three prediction models: the ...
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Cold atmospheric plasma shows promise to help fight the spread of COVID-19
Plasma is one of the four basic states of matter. Cold atmospheric plasma is an ionized room-temperature gas. Though it is a relatively new technology, plasma has been proven to be effective in multiple different medical applications including in cancer treatments, wound healing, dentistry and more. Researchers at UCLA used an atmospheric pressure plasma jet to spray surfaces that were ...
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Absorbed dose using a nanoscale ion beam for Bragg peak calibrations
The proton beam was investigated for cancer cell therapy in the pancreas. Neon ion interaction profiles were compared with the result of the proton beam, which was investigated for nanoscale ion beam interactions. Simulation for the Bragg peak calculation was performed for interactions with a human organ, the pancreas. The results show the absorbed dose and dose equivalent, which vary with the ...
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ADC Drugs For Breast Cancer Treatment
Breast cancer is the malignant tumor with the highest morbidity and mortality among women worldwide. At present, the main therapeutic methods include surgery, chemotherapy, radiotherapy, endocrine therapy and targeted therapy, etc. The development and marketing of new drugs have far-reaching significance in improving the survival of breast cancer patients and changing the pattern of breast cancer ...
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A brief overview of the research reactor FRM II
The research reactor Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II) is operated using a single compact fuel element embedded in a large heavy water filled moderator tank. Consequently the thermal neutron flux density exhibits its maximum value outside the fuel element in an area which is accessible for experimental installations. A further advantage of the use of heavy water is that it ...
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Hoffmann-La Roche - Ozone oxidation for the elimination of active pharmaceutical ingredients from wastewater - Case Study
Hoffmann-La Roche has set up a new facility in Toluca, Mexico for the production of two highly effective cancer treatment drugs. The wastewater generated in this context poses an ecotoxicological risk. Therefore, it needs to be eliminated at the source. Various methods were tested and evaluated from an ecological and economic perspective. According to preliminary studies, the best way to ...
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AU2012348311 - Reduction of galectin-3 levels by plasmapheresis
Abstract The invention is directed to the removal of serum gal-3 from circulation by plasmapheresis using gal-3 binding agents in either a fixed bed, or in a form easily removed, such as by being complexed with magnetic particles. This method, on its own, brings a sharp reduction and relief from the inflammation and fibroses that can be induced by circulating gal-3. The process may be combined ...
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Survivin as a biological biomarker for diagnosis and therapy
Survivin (SVN) is a member of the inhibitor of apoptosis (IAP) protein family that promotes cellular proliferation and inhibits apoptosis. Overexpression of SVN is associated with autoimmune disease, hyperplasia, and tumors and can be used as a biomarker in these diseases. SVN is widely recognized as a tumor-associated antigen (TAA) and has become an important target for cancer diagnosis and ...
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Improving drug loading efficiency and delivery performance of micro– and nanoparticle preparations through optimising formulation variables
In this report, we briefly introduce our recent studies related to drug delivery systems using biodegradable materials, PLGA, PLA or chitosan to prepare submicroparticles or microparticles for carrying vaccine, protein or small molecule drugs. These preparations were prepared by spray dried or solvent extraction methods. In addition, liposomal formulations containing various lipids and pegylated ...
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Institute of Cancer Research Makes Groundbreaking Treatment Discoveries With NM30LA - Case Study
The Institute of Cancer Research or ICR, is a world leading institution in cancer gene discovery, cancer drugs and innovations in radiotherapy. With the help of Peak's NM30LA gas generator ICR have managed to streamline their workflow. Name: Amin Mirza Job title: Head of Structural Chemistry Company: Institute of Cancer Research Location: London, UK One of ICR’s main priorities is to ...
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