cancerous breast Articles
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Raman ‘optical biopsy’ of human breast cancer
Abstract Raman imaging (RI) is a novel method of medical diagnostics of human breast cancer and has a potential to become a routine optical biopsy. Up to date the present study is the most statistically reliable Raman analysis based on data of normal, benign, and cancerous breast tissues for 146 patients. This paper present the first Raman ‘optical biopsy’ images of the normal and ...
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Mapk4 May Be a New Target for the Treatment of Triple-Negative Breast Cancer
There is now growing evidence that the MAPK4 enzyme may be involved in cancer growth and resistance to specific therapies. Recently, an article titled " MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade" was published in Nature Communications. By analyzing public genome databases, the researchers found that a large number of triple-negative ...
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Early Detection Saves Lives KBCT Can Help
Despite breast cancer being the second most common cancer for women in the US, progress in the breast imaging space has been stagnant over the last few decades. This is evident in the countless women who are still misdiagnosed – either receiving a false positive or getting diagnosed in the later stages of the disease. Why Early Detection is Important According to the National Breast ...
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Analysis of breast cancer in the Massachusetts TB fluoroscopy cohort and in the Japanese A-bomb survivors, taking account of dosimetric error and curvature in the A-bomb dose response: absence of evidence of reduction of risk following fractionated i
Breast cancer has occurred in excess among women exposed briefly to atomic bomb radiation and among those exposed repeatedly over many years to medical radiation for tuberculosis (TB). The breast cancer excess is strongly dependent on age at exposure, with risk highest among the young and small or non-existent when exposure occurs past the menopausal ages. The linear excess relative risk ...
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Transforming growth factor engages tace and erbb3 to activate pi3k/akt in erbb2-overexpressing breast cancer and desensitizes cells to trastuzumab
Departments of Cancer Biology, Medicine, Pathology, Breast Cancer Research Program, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN; Expression Analysis, Durham, NC; Centro de Investigación del Cáncer, CSIC-Universidad de Salamanca, ...
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ADC Drugs For Breast Cancer Treatment
Breast cancer is the malignant tumor with the highest morbidity and mortality among women worldwide. At present, the main therapeutic methods include surgery, chemotherapy, radiotherapy, endocrine therapy and targeted therapy, etc. The development and marketing of new drugs have far-reaching significance in improving the survival of breast cancer patients and changing the pattern of breast cancer ...
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Zanidatamab, a HER2-targeted bispecific antibody, in combination with docetaxel as first-line therapy for patients with advanced HER2-positive breast cancer: Preliminary results from a Phase 1b/2 study (American Society of Clinical Oncology)
Worldwide, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer deaths in women, with over 650,000 deaths in 2020.1,2 Human epidermal growth factor receptor 2 (HER2)-targeted agents have improved outcomes in HER2-positive breast cancer, but most patients in first-line therapy do not respond to current therapies, eventually relapse or develop ...
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Evaluation of radioinduced damage and repair capacity in human breast cancer cells, MCF-7 and T-47D
Ionising radiation is an established etiological agent for breast cancer, but is also a therapeutic modality used in cancer treatment. The accumulation of deoxyribonucleic acid (DNA) damage and deficient DNA repair are considered susceptibility factors that predispose individuals to breast cancer development. In the present study, the genetic damage induced by gamma radiation and repair capacity ...
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Carbon nanotube-based electrochemical signal amplification for breast cancer gene detection
Carbon-nanotubes (CNT) represent an important group of nanomaterials with useful properties that enable their use for many important applications and made them extremely attractive for the task of electrochemical detection. Here, the author uses CNT to enhance the sensitivity of a multi-enzyme-based electrochemical bioassay for breast cancer gene (BRCA1) detection. Giant enzyme-based ...
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Phase lb study of venadaparib, a potent and selective PARP inhibitor, in homologous recombination repair (HRR) mutated breast cancer
Poly ADP-ribose polymerase (PARP) is an enzyme that is central to the repair of DNA replication errors and are currently approved for ovary, breast, pancreas and prostate cancers. VASTUS study (NCT04174716)1' is a basket trial investigating the safety and efficacy of venadaparib in 6 cohorts (active recruiting) of different tumors, including breast ...
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Raman imaging at biological interfaces: applications in breast cancer diagnosis
Abstract Background: One of the most important areas of Raman medical diagnostics is identification and characterization of cancerous and noncancerous tissues. The methods based on Raman scattering has shown significant potential for probing human breast tissue to provide valuable information for early diagnosis of breast cancer. A vibrational fingerprint from the biological tissue provides ...
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ADC Drugs For HER2 Positive Breast Cancer
According to the latest data, breast cancer has overtaken lung cancer to become the most common cancer among women, and the death rate is the second highest among female tumors, seriously affecting the physical and mental health of women around the world. Patients with abnormal expression of human epidermal growth factor receptor (HER2) account for 15%-20% of all breast cancers, which is highly ...
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Gertsen Blinded Validation Project
Summary OTraces in collaboration with the Gertsen Institute in Moscow performed a blinded validation study on OTraces breast cancer detection products, the CDx Chemistry System for processing automated tests for detection of cancer; BC Sera Dx Immunochemistry test kit for the measurements of proteins that are predictive as a group of the presence on breast cancer in women; and the OTraces Cancer ...
By OTraces Inc.
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Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate
T-47D human breast cancer cells were irradiated with 60Co γ-radiation and radiation response was measured by loss of ability of single-cells to form colonies. The influence of the dose-rate on the ability of priming irradiation to abolish Low-Dose Hyper-Radiosensitivity (LDHRS) was investigated. In agreement with previous reports, the LDHRS was abolished by an acute priming dose of 0.3 Gy given 6 ...
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Infiltrating Ductal Carcinoma (IDC) - Case Study
Patient with positive family history of breast cancer and ovarian cancer. September 2003 mammogram reported benign micro calcifications. August 2007 patient presented with a palpable mass in lateral aspect of left ...
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New Breast Imaging Technology: The Koning Difference
Revolutionizing breast cancer detection Breast cancer is the most diagnosed cancer in women in the United States and the second leading cause of cancer death in American women.1 It is also treatable if detected early enough. While there are various cancer detection modalities available, current breast imaging devices fail to expose as much as 35% of breast cancers and that number increases to ...
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Feedback regulation between zipcode binding protein 1 and β-catenin mrnas in breast cancer cells
ZBP1 (zipcode binding protein 1) is an RNA-binding protein involved in many posttranscriptional processes, such as RNA localization, RNA stability, and translational control. ZBP1 is abundantly expressed in embryonic development, but its expression is silenced in most adult tissues. Reactivation of the ZBP1 gene has been reported in various human tumors. In this study, we identified a detailed ...
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Vision-based 3D surface motion capture for the DIET breast cancer screening system
Breast cancer is one of the most prevalent forms of cancer in the world today. The search for effective treatment and screening methods is a highly active area of research. The Digital Image-based Elasto-Tomography (DIET) project is a new breast cancer screening system under development, where surface motion from the mechanically actuated breast is measured in 3D, and used as input to an inverse ...
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AST 250kg load cell and cancer research
A study was approved by The University of Western Sydney Human Research Ethics to determine whether resistance training improves fatigue and quality of life in previously inactive breast cancer survivors. Upper body strength was measured by the force output during a unilateral isometric chest press. The force was measured using our AST 250kg Load Cell. The study found that 16 weeks of ...
By PT Limited
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IMOGEN - Contrast-Free Magnetic Resonance Imaging for Breast Disease - Case Study
This is an observational cohort study looking at women, 30 years of age or older with a concern or at risk of suspected breast disease or breast cancer. The proposed study aims to examine the diagnostic performance of non-contrast MRI in breast disease by applying quantitative multiparametric MRI ...
By Perspectum
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