carcinoma Articles
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VLE for Pre-Treatment Planning using Real-time Targeting - Case Study
Patient History A 58 year old male presented with a history of gastroesophageal reflux disease (GERD) and long segment Barrett's Esophagus (BE). During a prior exam, pathology returned high grade dysplasia (HGD) and suspected intramucosal carcinoma (IMCA). The purpose of this procedure was to localize areas of HGD and suspected IMCA using the NvisionVLE Imaging System and then use Real-time ...
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VLE for Identification of Subsquamous Disease - Case Study
Patient History This patient was a 68 year old man referred with short segment Barrett's Esophagus (BE) with intramucosal carcinoma (IMC). At the referring center, previous resection of nodularity revealed Tla adenocarcinoma with negative margins. Subsequent surveillance biopsies yielded IMC, and triggered referral. For the procedures described here, standard endoscopy with the addition of ...
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Clinical Case Study: Invasive Ductal Carcinoma (IDC) and Ductal Carcinoma In Situ (DCIS)
Description: Description: 71-year old female presented for a routine screening mammogram Protocol: PROTOCOL: 1. August 2007 left breast mammogram showed large area of abnormality lateral aspect of breast. Mammogram RT Breast CC Mammo RT Breast MLO Mammo 2. August 2007 left breast ultrasound showed mass at 1:00-3:00 ...
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Liposome encapsulated gold nanoshells for NanoPhototherapy induced hyperthermia
Gold nanoshells have been extensively studied since their invention and their role in both in vitro and in vivo photothermal therapy has been explored and demonstrated. In this work, we investigate liposomal delivery of gold nanoshells and evaluate their effects for in vitro NanoPhototherapy induced hyperthermia in human mammary carcinoma cells. In addition, we compare the application of liposome ...
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Clinical Case Study: Ductal Carcinoma In Situ (DCIS)
Description: Patient presented with a palpable left breast lump. PROTOCOL: 1. August 2007 left breast mammogram showed large area of abnormality lateral aspect of breast. Mammogram Left_CC_Mam Left MLO Mam 2. August 2007 left breast ultrasound showed mass at 1:00-3:00 position and prominent rounded nodes ...
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Curcumin loaded organically modified silica (ORMOSIL) nanoparticle; a novel agent for cancer therapy
Curcumin is a polyphenol compound extracted from the rhizome of turmeric (Curcuma longa) and has a well established anticancer property. However poor aqueous solubility is a major hindrance for its bioavailability and therapeutic use. Nanoparticle based system can be developed to overcome this problem. Present study has been undertaken with curcumin loaded organically modified silica (ORMOSIL) ...
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MK-4101
MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma. target:SMO In vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in ...
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Infiltrating Ductal Carcinoma (IDC) - Case Study
Patient with positive family history of breast cancer and ovarian cancer. September 2003 mammogram reported benign micro calcifications. August 2007 patient presented with a palpable mass in lateral aspect of left ...
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Labelling of albumin microspheres with 188Re: a possible agent for radiotherapy
Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was ...
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Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma
Abstract The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a more malignant cell state. To discover novel druggable targets for cancers carrying co-mutations in Ras and p53, we performed arrayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of syngeneic Ras mutant ...
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Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice
Constitutive ß-catenin/Tcf activity, the primary transforming events in colorectal carcinoma, occurs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyposis. Mice carrying Apc mutations in their germ line (ApcMin) develop intestinal adenomas. Here, the crossing of ApcMin with cyclin D1–/– mice reduced the intestinal tumor number in animals genetically ...
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Segmentation of the Main Structures in Hematoxylin and Eosin Images
Pathologists conduct a biopsy on a tissue when a carcinoma case for a patient is suspected. They stain the cells on that tissue using some biochemical materials that react with a certain cell element. They put stained cells onto a slide and examine the cells by using an optical microscope device. In our case, we will focus on H&E stained breast tissue samples. Pathologists keep track of a ...
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Development of a System for the Early Diagnosis of Breast Cancer
We are now developing a system which allows the visualization of the structure and tissue associated with breast cancer, which is difficult to achieve with conventional mammography, by utilizing X-ray refraction. This system is expected to achieve an approximately 1000-fold higher contrast and high spatial resolution at low dose; compared to techniques by use of X-ray absorption. Monochromatic ...
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Chronic cadmium exposure promotes nasopharyngeal carcinoma
Chronic cadmium exposure promotes nasopharyngeal carcinoma progression and radioresistance Dr Lin Peng and her team investigate how environmental pollutant exposure influences the risk of cancer development and therapeutic resistance at the Department of Laboratory Medicine, Cancer Hospital of Shantou University Medical College, ...
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Lung cancer and mesothelioma in towns with environmental exposure to asbestos in Eastern Anatolia
Objective: Our previous study demonstrated the presence of environmental tremolite and chrysotile asbestos fiber exposure in Hekimhan town in Malatya located in eastern Turkey. The aim of this study was to investigate whether environmental asbestos exposure increases the incidence of lung cancer and mesothelioma. Method: One hundred and forty-nine patients with mesothelioma and lung cancer living ...
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Expanded and Activated Natural Killer Cells for Immunotherapy of Hepatocellular Carcinoma
Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. Using the K562-mb15-41BBL cell line as a stimulus, we obtained large numbers of activated NK cells from the peripheral blood of healthy donors. ...
By Nkarta, Inc.
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Prediction of chemotherapeutic response in ovarian cancer with DNA microarray expression profiling
Abstract Ovarian carcinoma is a leading cause of gynecologic cancer death in women. Despite treatment, a large number of women with ovarian cancer eventually relapse and die of the disease. Hence, recurrent ovarian cancer continues to be a therapeutic dilemma, possibly a result of the emergence of drug resistance during relapse. Recent advances in expression genomics enable global transcript ...
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Potentials of transforming growth factors alpha and beta-1 in predicting the clinical outcome of bladder carcinoma
The 'protein traffic hypothesis' suggests that the inflammation associated with autoimmune disease, trauma and disturbances of blood circulation is the result of misguided protein trafficking. The hypothesis divides the antigen spectrum into an intracellular component and an extracellular component. While the intracellular component is recognised by MHC class-I molecules and is presented to CD8 ...
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An Emerging Aim: ADC Target Protein - Nectin-4
The biologics license application (BLA) has been accepted for Enfortumab Vedotin for the treatment of locally advanced or metastatic urothelial carcinoma in patients who have previously received PD-1/PD-L1 inhibitors and platinum-containing chemotherapy. Enfortumab Vedotin is the first domestically submitted targeted antibody-drug conjugate that specifically targets Nectin-4. Enfortumab ...
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Pioneering VeraForm in Head and Neck Cancer Treatment: Sarcomatoid Carcinoma Tumor Bed Marking
Head and neck cancer surgery presents a number of unique challenges, not only for the surgeon but for the radiation oncologist who will subsequently treat those patients. Great care with an emphasis on precision must be taken to ensure that critical structures and tissues avoid collateral damage when possible. However, given the surgical site often lies in soft tissue, exact identification of the ...
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