Carcinoma Articles & Analysis
44 articles found
The IonVision system was tested with porcine skin, and then further refined to analyze a small number of human basal cell carcinoma and healthy skin samples. The classification accuracies achieved (over 90 %!) ...
Background of Caco-2 Cells Caco-2 cells are derived from human colorectal carcinoma and possess characteristics that mimic intestinal epithelial cells. ...
Clinical trials are the backbone of modern medicine, responsible for bringing innovative, safe, and efficient treatments to market after rigorous testing and evaluation. However, the conventional process of conducting these trials has often been long, expensive, and fraught with inefficiencies¹. The advent of predictive analytics is reshaping the landscape of clinical trials, ushering in a ...
Background and objective High grade serous carcinoma (HGSC) of the ovary is a complex and deadly disease. Although frontline treatment of chemotherapy and surgery is often effective, with nearly all patients experiencing remission, over 80% of patients will experience disease recurrence in the first two years and ultimately die of the disease. ...
However, Merck's bispecific ADC pipeline M1231 also targets EGFR/MUC1, which is co-expressed in a variety of tumor cells, including non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma (ESCC), head and neck squamous cell carcinoma cell carcinoma, triple-negative breast cancer, and ovarian cancer, among others. ...
Due to the high conservation of the backbone region of HA2, it represents an excellent target.Hepatitis VirusesInfection with hepatitis C virus (HCV) can lead to liver diseases such as cirrhosis or hepatocellular carcinoma. The development of effective HCV vaccines has been hindered by the variability of sequences within T cell-targeted epitopes. ...
Aberrantly glycosylated CD73 and a human-specific CD73 isoform (CD73s)[22] have been identified in human hepatocellular carcinoma (HCC), leading to the functional suppression of tumor CD73. Additionally, CD73 expression was found to be downregulated in advanced-stage prostate, laryngeal, and high-grade colon carcinomas. Lower CD73 expression levels were observed ...
In NSCLC, high Trop-2 expression was observed in 64% of adenocarcinomas and 75% of squamous cell carcinomas (SqCCs). In addition to its function of regulating normal fetal development, Trop-2 is also an intracellular calcium signal transducer, a key component of cell adhesion in human tissues, and plays an important role in stabilizing epithelial tight junctions. ...
CADM1 and Head and Neck Squamous Cell Carcinoma (HNSCC) CADM1 is often downregulated in HNSCC and may function as a tumor suppressor. ...
The biologics license application (BLA) has been accepted for Enfortumab Vedotin for the treatment of locally advanced or metastatic urothelial carcinoma in patients who have previously received PD-1/PD-L1 inhibitors and platinum-containing chemotherapy. ...
The full name of TROP2 protein is trophoblast cell surface antigen 2, which is highly expressed in a variety of tumors, such as pancreatic cancer, breast cancer, colon cancer, bladder cancer, oral squamous cell carcinoma and ovarian cancer. On June 7, 2022, sacituzumab govitecan was officially approved in China for the treatment of patients with unresectable locally advanced or ...
By studying anthropology, intervention in some diseases could be more efficient. Take esophageal carcinoma as an example. In China, people from two areas have a high incidence of esophageal carcinoma: Tai Mountain and the Chaoshan area in Guangdong Province. ...
The main objective of the Company is to bring new diagnostics to the market and improve cancer prognosis by allowing physicians to detect carcinomas in the pre-symptomatic stages, when approximately 90% of cancers can be cured. ...
FAUST was applied to data from a pivotal Merkel cell carcinoma anti-PD-1 clinical trial and discovered hundreds of phenotypes which was visualized with a novel embedding. ...
In existing studies of human epidermoid carcinoma cell lines expressing mesothelin, biodistribution analysis of mesothelin using radiolabeled monoclonal antibodies showed good localization and specificity for relevant tumors. ...
Medical History Jane is a 40-year-old, married mother of two teenage boys. She teaches at the local elementary school and has been in good health for most of her life. She has no surgical history. Her most severe ailment up to this point has been the flu at age 27. Her students are first-graders; they are often difficult to control. She also experiences the normal stresses of raising ...
TROP2 is expressed in various malignant tumors, including breast carcinomas and pancreatic carcinomas. TROP2 is a membrane-bound glycoprotein commonly expressed in several tissues, including the prostate. ...
Moreover, LFQ is commonly used in biomarker detection of other diseases and tumors, such as Vps35 for Parkinson's disease, SOAT1 for hepatocellular carcinoma, GOT2 for prostate cancer, A1AT for bladder cancer. Stable isotope labeling with amino acids in cell culture (SILAC) Stable isotope labeling with amino acids in cell culture is an in vivo metabolic labeling method, which ...
Methods: We identified 275 patients who underwent surgical resection for pathologic stage I-II lung adenocarcinoma or squamous cell carcinoma from 2009 to 2019 in our institution’s prospective surgical database. ...
Patient History This patient was a 68 year old man referred with short segment Barrett's Esophagus (BE) with intramucosal carcinoma (IMC). At the referring center, previous resection of nodularity revealed Tla adenocarcinoma with negative margins. ...