cardiac function Articles
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Reactive oxygen species regulate hypoxia-inducible factor 1 differentially in cancer and ischemia
In exercise, as well as cancer and ischemia, hypoxia-inducible factor 1 (HIF1) transcriptionally activates hundreds of genes vital for cell homeostasis and angiogenesis. While potentially beneficial in ischemia, upregulation of the HIF1 transcription factor has been linked to inflammation, poor prognosis in many cancers, and decreased susceptibility of tumors to radiotherapy and chemotherapy. ...
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Reactive oxygen species regulate hypoxia-inducible factor 1 differentially in cancer and ischemia
In exercise, as well as cancer and ischemia, hypoxia-inducible factor 1 (HIF1) transcriptionally activates hundreds of genes vital for cell homeostasis and angiogenesis. While potentially beneficial in ischemia, upregulation of the HIF1 transcription factor has been linked to inflammation, poor prognosis in many cancers, and decreased susceptibility of tumors to radiotherapy and chemotherapy. ...
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An In-depth Analysis of hERG (IKr, Kv11.1): Its Function, Role, and Importance
Introduction hERG, which stands shorthand for the human Ether-à-go-go-Related Gene, generates the protein responsible for a certain type of potassium channel in the human heart, denoted as IKr or Kv11.1. The role of this potassium channel is fundamental for normal cardiac function, playing a vital role in the termination of the cardiac action potential and ultimately contributing to the ...
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Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance
Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, as crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migratory success and fitness. Yet the sensitivity of early life‐stage salmon to dilbit ...
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Injecting mRNA and generating CAR-T directly in the body to repair the heart in one shot
January 6, 2022—Researchers at the Perelman School of Medicine at the University of Pennsylvania published a research paper in Science titled: CAR-T cells produced in vivo to treat cardiac injury. Heart damage or inflammation can induce fibroblasts to overproduce fibrous material, causing cardiac fibrosis, which hardens the heart muscle and impairs heart function. Heart failure, liver ...
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Top Advances in Echocardiography Transforming Cardiac Imaging on World Heart Day
In honor of World Heart Day on September 29, we're diving into the world of cardiovascular diagnostics. Echocardiography, one of the most widely used screening and diagnostic modalities in healthcare, has seen a resurgence thanks to advances and groundbreaking innovations within the last few years. Join us as we explore the top trends shaping these diagnostic methods. 1. ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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CPR Vs. AED Training: What’s The Difference?
Every second counts in any emergency, particularly those involving sudden cardiac events. Training in life-saving procedures becomes pivotal in ensuring that a victim has the best chance of survival. Two terms that often surface in discussions about cardiac emergencies are CPR vs. AED training. While both aim at preserving life during cardiac crises, they serve different functions and involve ...
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UCT Silane Cited in Organ-On-Chip
The ventricular myocardium of the human heart is composed of an anisotropic tissue structure that allows for force generation and contraction to pump blood throughout the body. It has long been established that the collagen-rich, fibrous, extracellular matrix environment guides the formation of this laminar tissue architecture. The structural and mechanical properties of the cardiac ...
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Baroreflex Activation Therapy: A Novel Approach for HFrEF Patients
During the webinar, you’ll learn about: Treatment options and unmet needs of HFrEF patients The physiologic rationale of baroreflex activation Barostim therapy overview and clinical evidence overview Appropriate patient selection and real-world experience Important Safety Information CAUTION: Federal law restricts this device to sale by or on the ...
By CVRx
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