Cell And Gene Therapy Articles & Analysis: Older
102 articles found
These technologies allow scientists to cut, insert, or modify specific DNA sequences, enabling the customization of T cells to recognize and attack disease-specific antigens. Applications in Cancer Therapy One of the most promising applications of gene editing in primary T cells is in cancer therapy. ...
Cytokines are a diverse group of small protein molecules that play crucial roles in the immune system and various biological processes. They are synthesized and secreted by a range of immune cells, including monocytes, macrophages, T cells, B cells, and natural killer (NK) cells, as well as certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines are produced ...
Human umbilical cord cells, particularly those found in Wharton’s jelly, have emerged as a focal point in regenerative medicine and cellular therapy. Wharton’s jelly is a gelatinous substance that surrounds the umbilical cord’s blood vessels, providing structural support and protection. It is rich in mesenchymal stem cells (MSCs), which are known for their unique regenerative ...
Human corneal epithelial cells play a vital role in maintaining the health and function of the cornea, the transparent front part of the eye. This layer of cells acts as a protective barrier against environmental insults, pathogens, and mechanical injury. Given their crucial functions, understanding these cells is essential for advancements in ophthalmology and regenerative medicine. The corneal ...
Human brain has approximately 171 billion cells, of which slightly more than half (approximately 86 billion) are nerve cells. These 86 billion nerve cells are a diverse cell population with hundreds of specialized types and functions, but all originate from three neural cell lineages--neurons, oligodendrocytes and astrocytes. All three cell lineages originate from a pool of neural stem and ...
This article aims to engage in an incisive analysis of cell and gene therapies, decoding their transformative implications on human health and medical research. ...
GMP growth factors and cytokines designed for therapeutic manufacturing are an essential component of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct contact with patients. In fact, ...
In cancer research, zebrafish models have advantages over traditional cell culture assays because a wider range of phenotypes can be tested. ...
As a biology researcher, staying at the cutting edge of technology is crucial to advancing research in the field. The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. However, the monitoring and detection of CAR-T cells in vivo remain a challenge in the evaluation ...
Through peptide sequencing, we can discover new peptide drugs with specific bioactivity, such as peptide hormones and peptide antibodies, providing powerful tools for targeted therapy. At present, peptide drugs have shown broad application prospects in the treatment of tumors, hepatitis, diabetes, and AIDS.Antibody-Based TherapyAntibodies are proteins produced by the immune ...
Pancreatic cancer is one kind of cancer that originates from the pancreas, an important organ behind the stomach. When cells in the pancreas grow uncontrollably, they can form tumors and trigger cancer. ...
The quest for transformative cell and gene therapies has ignited a wave of innovation in biopharmaceuticals. As the industry races to unlock these treatments’ full potential, the intricacies of therapy development present unprecedented challenges. From navigating a highly regulated environment to ensuring streamlined ...
The process of iPSC differentiation to neurons and neuronal cells is of special importance for neurobiology and related disorders, considering the dearth of clinically relevant in vitro models available for research, drug screening and development, as well as the lack of therapy to reverse neuronal damage. ...
In addition, carboxylic acid PEGs can be involved in regulating interactions with cells, such as fusion with cell membranes and cellular uptake, providing effective carriers for cell therapy and gene delivery. ...
This conjugate can selectively deliver the drug to disease-related cells, such as cancer cells, thereby increasing efficacy and reducing toxicity to normal tissues.ADC is a complex composed of an antibody and a drug (usually a cytotoxic drug). The antibody component specifically targets surface antigens on specific cancer cells, while the drug ...
In the field of medicine, effectively delivering drugs to the target site in the body is crucial for successful treatment. Over the years, several innovative drug delivery systems have been developed to improve drug efficacy and patient outcomes. In this article, we will discuss four novel drug delivery systems that have shown promising results in recent research. These systems include ...
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. As a "living" drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for the treatment of tumors. Compared with ...
This article aims to engage in an incisive analysis of cell and gene therapies, decoding their transformative implications on human health and medical research. ...
Understanding these pathways is crucial for advancing our knowledge of B cell biology and developing targeted therapies for B cell-related diseases. ...
Oligonucleotides and siRNA are important tools for regulating protein activation and post-transcriptional gene expression, and are important means for targeted therapy of specific genes. siRNA can play its role in gene therapy through post-transcriptional gene silencing. ...