Cell And Genetic Therapies Articles & Analysis
113 articles found
In modern biopharmaceutical manufacturing, downstream processing development has become one of the most critical and resource-intensive stages. While upstream cell culture or fermentation focuses on producing the target biomolecule, downstream steps transform crude harvests into highly purified and stable therapeutic products. For biologics such as monoclonal antibodies, recombinant proteins, and ...
The BCL2 gene, short for B-cell lymphoma 2, is a critical regulator of apoptosis, or programmed cell death. ...
By administering recombinant chemokines, scientists can redirect immune cells to the tumor microenvironment, potentially enhancing the efficacy of checkpoint inhibitors or CAR-T cell therapies. ...
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer ...
Podocytes are specialized epithelial cells located in the kidneys, playing a crucial role in the filtration barrier of the glomerulus. These unique cells have garnered significant attention in scientific research due to their pivotal function in maintaining kidney health and their involvement in various kidney diseases. The Structure and Function of Podocytes Podocytes possess a distinct ...
Organoids can reproduce multiple biological interactions—such as cell-to-cell and cell-to-matrix communication—and execute tissue-specific physiological functions. ...
Alfa Cytology unveils advanced PD-1 inhibitor development service for cancer research. Alfa Cytology, a prominent service provider in the oncology landscape, has recently launched its innovative PD-1 inhibitor development services. This initiative marks a significant advancement in the quest for more effective cancer therapies, focusing on enhancing precision and adaptability in treatment ...
In the ever-evolving landscape of cancer research, two intriguing concepts have emerged that are reshaping how scientists approach treatment: synthetic lethality and parthanatos. Both concepts encapsulate the complexity of cellular processes and open new avenues for targeted therapies. What is Synthetic Lethality? Synthetic lethality occurs when the simultaneous disruption of two genes ...
Immuno-oncology is an innovative field that utilizes the body’s immune system to combat cancer. By harnessing the natural capabilities of the immune system, immuno-oncology services are revolutionizing the way we approach cancer treatment, offering novel therapies that are changing the prognosis for many patients. Understanding Immuno-Oncology Immuno-oncology focuses on the interaction ...
M Phase (Mitosis) l The nucleus divides, and chromosomes are evenly distributed between two daughter cells. l This step ensures genetic material is faithfully inherited by new cells. 5. ...
Alfa Cytology unveils advanced cancer immunotherapy development services. Alfa Cytology, a renowned services supplier in oncology, has recently introduced its groundbreaking cancer immunotherapy development services. This initiative signifies a major leap forward in the development of more effective cancer therapies, aiming to boost both precision and versatility within treatment paradigms. ...
Among the various forms of immunotherapy, CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) has shown promise, particularly in treating acute lymphoblastic leukemia (ALL), especially in children and young adults. This therapy involves genetically modifying a patient’s ...
The primary focus is on harnessing this technology for modifying primary T cells, a type of white blood cell crucial for the immune response. This approach has opened new avenues for immunotherapy, providing hope for treating conditions like cancer, autoimmune disorders, and genetic diseases. ...
Cytokines are a diverse group of small protein molecules that play crucial roles in the immune system and various biological processes. They are synthesized and secreted by a range of immune cells, including monocytes, macrophages, T cells, B cells, and natural killer (NK) cells, as well as certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines are produced ...
Human umbilical cord cells, particularly those found in Wharton’s jelly, have emerged as a focal point in regenerative medicine and cellular therapy. Wharton’s jelly is a gelatinous substance that surrounds the umbilical cord’s blood vessels, providing structural support and protection. It is rich in mesenchymal stem cells (MSCs), which are known for their unique regenerative ...
Human corneal epithelial cells play a vital role in maintaining the health and function of the cornea, the transparent front part of the eye. This layer of cells acts as a protective barrier against environmental insults, pathogens, and mechanical injury. Given their crucial functions, understanding these cells is essential for advancements in ophthalmology and regenerative medicine. The corneal ...
GMP growth factors and cytokines designed for therapeutic manufacturing are an essential component of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct contact with patients. In fact, ...
In cancer research, zebrafish models have advantages over traditional cell culture assays because a wider range of phenotypes can be tested. ...
Human brain has approximately 171 billion cells, of which slightly more than half (approximately 86 billion) are nerve cells. These 86 billion nerve cells are a diverse cell population with hundreds of specialized types and functions, but all originate from three neural cell lineages--neurons, oligodendrocytes and astrocytes. All three cell lineages originate from a pool of neural stem and ...
Cell therapy constitutes a form of treatment where live cells are induced into a patient's body to effectuate reconstruction or repair of damaged tissue or to enhance the body's immune system. ...