cell therapy Articles
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bit.bio CEO featured in TechRound
bit.bio featured in TechRound's look forward at 2022. bit.bio CEO Dr Mark Kotter joined several experts giving their thoughts on what is to come for the health sector in 2022. His focus was on what will happen in the cell therapy space coupled together with synthetic biology ...
By bit.bio
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This Startup Is Making — and Programming — Human Cells
bit.bio was featured in Wired after an interview with CEO Mark Kotter and CMO Ramy Ibrahim. They cover our opti-ox™ technology which has the ability to manufacture cells consistently at scale. The piece also explains how cell reprogramming could help develop whole new kinds of treatment such as cell ...
By bit.bio
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Sterility Assurance Applied to Stem Cell Therapies
Abstract Stem cell therapies are becoming more important in the pharmaceutical industry. The genetic manipulations of the cells involved create a powerful tool to treat serious diseases, such as cancer. In 2017, the Food and Drug Administration (FDA) made several advancements towards regulation of stem cell therapy: Published perspective on stem cell therapy in the New England Journal of ...
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Natural Killer Cells May Be Scaled and Engineered as a Next Generation, Off-the-Shelf Cell Therapy for Cancer
The advent of immunotherapies for cancer, and more recently of cellular immunotherapies, has substantially altered the treatment landscape. In hematological malignancies, complete response rates to CAR-T cells can exceed 80%. These responses are often durable in nature and have attracted considerable excitement and investment in the development of cell therapies for an expanded range of ...
By Nkarta, Inc.
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bit.bio CEO features in Charles River Laboratories Disruptor series
bit.bio CEO Mark Kotter is featured as part of the Disruptor series from Charles River Laboratories (CRL). The series, created by CRL, celebrates the work of their partners, engaging in meaningful conversation about the current state of human health and future of scientific innovation and its impact. Mark discusses bit.bio's software approach to biology and how human cells that are programmed ...
By bit.bio
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Absorbed dose using a nanoscale ion beam for Bragg peak calibrations
The proton beam was investigated for cancer cell therapy in the pancreas. Neon ion interaction profiles were compared with the result of the proton beam, which was investigated for nanoscale ion beam interactions. Simulation for the Bragg peak calculation was performed for interactions with a human organ, the pancreas. The results show the absorbed dose and dose equivalent, which vary with the ...
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Injecting mRNA and generating CAR-T directly in the body to repair the heart in one shot
January 6, 2022—Researchers at the Perelman School of Medicine at the University of Pennsylvania published a research paper in Science titled: CAR-T cells produced in vivo to treat cardiac injury. Heart damage or inflammation can induce fibroblasts to overproduce fibrous material, causing cardiac fibrosis, which hardens the heart muscle and impairs heart function. Heart failure, liver ...
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A Comparative Data Set Showcasing MatriClone Matrices for iPSCs
For this month’s reagent round up, I would like to share a comparative data set showcasing our MatriClone matrix. MatriClone is an exciting opportunity for customers looking to accelerate their cell therapy workflows and deliver new treatments to market. For those who are not familiar with the matrix, it is comprised of truncated recombinant Laminin-511 protein and is designed to support ...
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Maintaining Quality in Stem Cell Products: Recent Developments in Regulation (Series Part 1 of 4)
Background Stem cells are naturally occurring cells in the body that have the ability to divide and produce a range of different cell types. They are important in the growth and development of the body as well as repair after injury. The past few years have brought a dramatic increase in the body of knowledge concerning stem cells, and their research and investment into uses in medicines1. ...
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Science: Knockout of this epigenetic gene gives CAR-T cells the ability to continuously attack cancer cells
Simply put, CAR-T is to transform the patient's immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells. In 2017, CAR-T therapy was first approved by the FDA for the treatment of blood cancers such as leukemia and lymphoma. ...
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Application of refractable nanocomposite on cell based therapy in central nervous system
Quantum Dots (QDs) are nano–particles carrying high stability fluorescence to follow the grafted cells which can be used in investigating the movement of cells and understanding the organogenesis of stem cells during development and wound repair processes in adulthood. For its easy acquirement and bypassing moral ethical issues, it makes the human adipose derived stem cells an attractive, ...
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Effect of interferon receptor pathway on CAR-T cell-mediated killing of solid tumors
Researchers at Massachusetts General Hospital (MGH) have found that interferon gamma receptor (IFNgR) signaling is essential for the susceptibility of CAR-T cell immunotherapy to kill malignant gliomas. The same phenomenon has been observed in other solid tumors. The findings may partially explain why liquid and solid tumors respond very differently to CAR-T cell therapy. Chimeric antigen ...
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A Comprehensive Analysis of Cell and Gene Therapy
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...
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Therapeutic Massage for Arthritis in Pets
As most of you know by now, arthritis is one of the most common diseases that afflicts pets. In fact, according to most estimates, 1 in 5 dogs is affected by osteoarthritis. Additionally, it is estimated that 40-92% of cats are affected by arthritis. There are numerous potential treatment modalities for arthritis including medications, rehabilitation, and even VetStem Cell Therapy. Another ...
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A Novel Potential Target for CAR-T Cell Therapy in Human Solid Tumors Discovered
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in clinical studies, cell therapy has actually not been successful in the treatment of patients with solid tumors, in part due to the lack of tumor targets ...
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Natural killer cell reprogramming with chimeric immune receptors
Abstract Natural killer (NK) cells are emerging as a new tool for cell therapy of cancer. However, some cancer subtypes are relatively resistant to NK cell cytotoxicity. Expression of anti-CD19 chimeric signaling receptors can enhance NK-cell reactivity against CD19+ leukemia and lymphoma cells. Here we describe a method to enforce expression of such receptors in human NK cells relying on ...
By Nkarta, Inc.
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Interview with Hoyoung Yun, CEO of Curiosis
‘Curiosity is the most powerful asset you own.’ CEO of Curiosis, Hoyoung Yun interviews with MedicalTimes and talks about the company’s products, technologies, achievements, and prospects. Curiosis is a company that provides cell-related diagnostic devices and lab automation which are needed in producing cell therapy products. The company launched new live cell imaging products, ...
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The Problem with Gene-Modified Cell Therapy Manufacturing
Gene-modified cell therapies (GMCTs) represent the most effective therapeutic platform for many patients with advanced diseases including relapsed and refractory leukemia, non-Hodgkin lymphoma, and other blood cancers [1]. Specifically, chimeric antigen receptor T cell (CAR-T) therapies targeting CD19 have demonstrated remarkable responses and possibly cures in patients with advanced acute ...
By Indee Labs
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bit.bio featured in TechRound list of top University of Cambridge spin outs
bit.bio featured in TechRound's article about startups that have spun out from the University of Cambridge. Other companies featured include Sano Genetics, Meshed, Cambridge Future Tech and WOAW. Izzy Murphy writes about how these businesses were spun out of Cambridge and evolved into the successful companies they are today. She covers how the idea for bit.bio’s fundamental technology ...
By bit.bio
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VetStem Cell Therapy Helps Senior Lab Walk Again
We absolutely love hearing stem cell success stories from pet owners. But some stories are extra touching because it’s clear that VetStem really improved a pet’s quality of life. That’s the case with Molly, a senior chocolate lab who was suffering from severe osteoarthritis and a potential spinal ...
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