central nervous system Articles
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Application of refractable nanocomposite on cell based therapy in central nervous system
Quantum Dots (QDs) are nano–particles carrying high stability fluorescence to follow the grafted cells which can be used in investigating the movement of cells and understanding the organogenesis of stem cells during development and wound repair processes in adulthood. For its easy acquirement and bypassing moral ethical issues, it makes the human adipose derived stem cells an attractive, ...
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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4 expression results in embryonic lethality (10.5 days postcoitum [dpc]), which was rescued by transferring the Mdm4 mutation into a Trp53-null background. Mutant embryos were characterized by overall growth deficiency, anemia, improper neural tube closure, and dilation of ...
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Building effective institutional frameworks to support pharmacogenetic research: an international empirical analysis
As science unravels the genetic basis of disease, the opportunities offered by pharmacogenetics and pharmacogenomics (PGx) for future healthcare become more and more apparent. The objective of this paper is to analyse the current state of PGx research and explore future strategies for more efficient research projects and supportive infrastructures. Based on internet searches and an online survey ...
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Regulation of cancer by therapeutic vaccination and dietary bio-modulation involving organ-specific mitochondria
Cancer therapy should aim to prevent recurrent disease. Surgery and toxic treatments remove only symptoms associated with cancer without trying to intervene in the aetiology, therefore the disease may recur. The autologous cancer vaccine supplemented with bio-modulation might fulfil requirements for effective tumour therapy. The autologous tumour vaccine is formed in the same way as our bodily ...
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Essential role for epidermal growth factor receptor in glutamate receptor signaling to nf-b
Glutamate is a critical neurotransmitter of the central nervous system (CNS) and also an important regulator of cell survival and proliferation. The binding of glutamate to metabotropic glutamate receptors induces signal transduction cascades that lead to gene-specific transcription. The transcription factor NF-B, which regulates cell proliferation and survival, is activated by glutamate; ...
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Acute exposure to DE‐71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae
The aim of the present study was to investigate the acute developmental neurotoxicity of polybrominated diphenyl ethers (PBDEs) in zebrafish larvae. From 2 to 120 h postfertilization Zebrafish embryos at were exposed to DE‐71 (0, 31.0, 68.7, and 227.6 µg/L). We studied the locomotor behavior of larvae, involvement of the cholinergic system, and selected gene and protein expressions in the central ...
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Absorption, distribution, and biotransformation of hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine (RDX) in B6C3F1 mice (Mus musculus)
Absorption, distribution, and biotransformation are three critical aspects affecting toxicant action in animals. In this study, B6C3F1 mice (Mus musculus) were exposed for 28 days to contaminated feed that contained one of five different RDX concentrations: 0, 0.5, 5, 50, 500 mg/kg. RDX (Hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine) and its reductive transformation products: MNX ...
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Prominent Names in RNA Delivery Discuss What’s Around the Corner
Oxford Global kicked off another exciting discussion group all about RNA therapeutics and emerging technologies for their delivery. Those attending were experts from the leading authorities in the field. Leading the conversation was Susan Rosenbaum, Founder, Chairman, and CEO of Lauren Sciences, a company that has been the recipient of twelve foundation grant awards and won first prize for Global ...
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Looking to the Future of Neuro Devices: Exclusive Interview with Alcyone Lifesciences CEO PJ Anand
Alcyone Lifesciences is a medical technology company based out of Lowell, MA, which specializes in central nervous system (CNS) drug delivery platforms for targeted infusions of the brain or spinal cord. Their Thecaflex DRx System was recently awarded Breakthrough Device designation by the FDA, for spinal infusion of therapeutic medications. Medgadget had the opportunity to speak with Alcyone ...
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Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration
School of Biological Sciences, The University of Hong Kong, Hong Kong, China. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Hong Kong, China. School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, ...
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Effect of mercury on the human health and environment: an overview
This article aims to review and to demonstrate the effect of mercury on the human health and environment. Mercury is one of the 12 toxic pollutants identified by the US Environmental Protection Agency and can be toxic at low levels in the environment. Mercury can stay in the atmosphere for up to a year. When released to the air, mercury is transported and deposited globally. Mercury ultimately ...
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Health and Safety in Heavy Industries
Many vapours and gases found in heavy industries pose an explosion risk. For any gas to combust it must reach its lower explosive limit (LELs). Lower explosive limits have been well established for 100s of chemicals and generally vapours from VOCs have relatively low explosion limits. For example, methane and hydrogen have LELs of 50,000 ppm and 40,000 ppm respectively whereas benzene has ...
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Cell-Penetrating Peptides: Features, Mechanisms, Applications
Cell-penetrating peptides (CPPs) refer to water-soluble, partly hydrophobic, and/or polybasic short peptides that are fewer than 30 amino acids in size. Different types of CPPs like chimeric peptides and hydrophobic peptides have different lengths, charges, solubility, and hydrophobicity. At current, cell-penetrating peptides are often classified in line with their characteristics, including ...
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Nature: Why do you just want to lie down when you get sick?
When we feel uncomfortable, we tend to eat less, drink less, and exercise less. This is not unique to humans—most animals reduce these three behaviors when fighting infection. Recently, a new study pinpoints clusters of neurons that control these responses (uncomfortable behavior). By provoking immune responses in mice, the researchers demonstrated that specific cell populations in the ...
By CD BioGlyco.
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Discovery of Pathways that Promote Remyelination
In the evolutionary history of vertebrates, the emergence of myelin has made the transmission of neural signals much faster, and if humans evolve like invertebrate squid, the vertebral diameter of humans may be thicker than that of giant red fir trees. Insulating myelin sheaths encapsulate nerve axons, thereby allowing rapid conduction of action potentials between neurons, and in addition, myelin ...
By Profacgen
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OCD: an "autoimmune disease"
Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a multifactorial disorder with an interplay of biological, psychological, and external factors, and ...
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Has the future of complement therapeutics arrived?
Silence Therapeutics, a pioneer in the development of novel small interfering RNA (siRNA) therapeutics, and Mallinckrodt plc, a global biopharmaceutical company, announced the submission of a clinical trial application (CTA) for SLN501, a siRNA therapy targeting the complement C3 protein, on March 23, 2022. Silence will receive a $3 million milestone payment from Mallinckrodt as a result of the ...
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Alkaloids: Nature's Chemical Wonders
In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. These naturally occurring compounds are known for their diverse chemical structures and profound biological activities. Many alkaloids have been discovered and studied extensively over the years, with more than 20,000 known alkaloids identified to date. Alkaloids ...
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Limits of Stability - The most used protocol for balance assessment
The Limits of Stability (LOS) is perhaps the most used protocol in the literature for balance assessment in a dynamic task. It quantifies the ability to intentionally displace the center of gravity to the patient’s stability limits without losing balance. This protocol provides information regarding voluntary motor control, which also helps screening fall risk in elderly people [1]. How ...
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Why CBD is your best workout buddy
CBD, short for cannabidiol, is the latest health buzzword but this healthful compound had been around since the year 2737 BC. According to The Center for Advancing Health, CBD was first brewed as tea to promote health and later used as a pain relief supplement during Victorian times. Today, you can find it in everything from face serums to workout supplements. It’s most commonly ...
By Relevium
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