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Cholesterol Articles & Analysis
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When you hear the word "sterol," your mind probably jumps to one famous, and often misunderstood, molecule: cholesterol. We’re constantly bombarded with messages about "good" and "bad" cholesterol, and its impact on our cardiovascular health. But what if I told you that cholesterol is just one member of a vast and vital family of molecules ...
At its core, Lipid Metabolism encompasses the intricate biochemical processes involved in the synthesis, breakdown, and transport of fatty acids, cholesterol, and other lipid molecules. Cholesterol, often unfairly maligned, is actually the cornerstone of steroid hormone production. Through a series of sophisticated enzymatic reactions, primarily occurring in the ...
This diverse category includes statins for cholesterol management, antihypertensives like ACE inhibitors and beta-blockers, anticoagulants, and antidiabetic agents. ...
Exosomal lipids, such as sphingomyelins, phosphatidylserines, and cholesterol, are critical in regulating exosome biogenesis, membrane fusion, and interaction with recipient cells. ...
Their ingredients are produced in bacteria or yeast through genetic engineering and are fortified with vitamins, cholesterol, specific amino acids and fatty acids. Protein-free medium Protein-free media do not contain any protein, only non-protein components. ...
It contains monounsaturated fats, which are beneficial for heart health and can help lower bad cholesterol levels. Olive OilOlive oil is a staple in Mediterranean cuisine and is known for its high content of monounsaturated fats. ...
ByMatexcel
Lipids are absorbed in two ways: triglycerides composed of medium- and short-chain fatty acids are absorbed after emulsification and enter the blood through the portal vein; triglycerides composed of long-chain fatty acids combine with apolipoproteins and cholesterol to form celiac particles and finally enter the blood through the lymph. ...
Furthermore, bile acids play a crucial role in the excretion of cholesterol and other waste products from the body, contributing to the maintenance of overall cholesterol homeostasis. In addition to their role in fat and cholesterol metabolism, bile acids possess antimicrobial properties, which can help to maintain a balanced gut microbiome and ...
In addition, supplementation of conventionally reared mice with specific bacterial strains resulted in increased body weight, elevated LDL and cholesterol levels, and altered expression of some genes involved in lipid transport. ...
Discovery of drug targets and lead compounds Many effective agents currently in use, such as cyclooxygenase inhibitors like rofecoxib and cholesterol-lowering drugs like simvastatin, target lipid metabolizing enzymes and thus regulate lipid metabolic networks. ...
And the research team hypothesized that the high ratio of fusion DOPE may facilitate the fusion of LNP into cells through the inverted hexagonal H(II) phase to destroy the endosomal membrane, thereby enhancing protein translation and promoting the endosomal release of encapsulated mRNA. AA3-DLin/DOPE/ cholesterol /DMG-PEG molar ratio of 40:40:25:0.5 was finally determined to be ...
Polysaccharide-peptide complexes isolated from mulberry leaves can lower blood sugar in diabetic mice induced by streptozotocin and also reduce plasma triglycerides and cholesterol. The hypoglycemic mechanism of mulberry leaf peptides may stimulate insulin secretion, relieve the degradation and inactivation of insulin in peripheral tissues, thereby increasing insulin blood ...
Bile acids are specialized molecules synthesized from cholesterol within the liver. These amphipathic compounds possess a hydrophilic region (carboxylic acid moiety) and a hydrophobic region (steroid backbone). ...
Bile acids are synthesized in the liver from cholesterol as a raw material. As a natural "emulsifier", they can promote the dissolution, digestion and absorption of fats, fat-soluble vitamins, etc. ...
N- & C-terminal modification Terminal modifications include polyethylene glycol (PEG) modifications and cholesterol modifications, which are usually introduced into the 5' or 3' end of the sense sequence. PEG modification can increase particle size, shield negative charge, and reduce cytotoxicity, thus avoiding nuclease degradation and renal clearance of siRNA in vivo as well ...
Furthermore, mammalian cell membranes contain cholesterol, enhancing membrane stability and preventing the insertion of AMPs, providing safety for the use of AMPs. ...
Apart from ionizable lipids, the other three components are also essential for LNPs. Helper lipids and cholesterol increase LNP stability and enhance cellular internalization. ...
It inhibits the synthesis pathway of cholesterol in osteoclasts, promotes the early apoptosis of osteoclasts, and inhibits the migration and attachment of osteoclasts. ...
Additionally, the inclusion of cholesterol or other stabilizing agents can enhance the stability and drug-loading capacity of the vesicles. ...
These mutations lead to immature synapses in the cerebral cortex, abnormal metabolism of cholesterol in the brain leading to abnormal neuronal development, and abnormal neuronal signaling. ...