cholesterol Articles
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Influence of dietary cholesterol and stress on the metabolism of linoleic acid: Δ6-desaturase activity vs. product/precursor ratios
Δ6-desaturase is a membrane bound enzyme located in a pivotal position within the Essential Fatty Acid metabolic pathway. Changes in the activity of Δ6-desaturase affect the cellular provision of long chain polyunsaturated fatty acids and therefore factors that influence this enzyme are considered relevant to disease processes. This study investigated the effects of social isolation stress and ...
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Biopharma PEG Supplies Cholesterol (Plant-Derived) Used As Excipients for Lipid Nanoparticles (LNPs)
Cholesterol, a derivative of cyclopentane polyhydrophenanthrene, is the main steroid compound in mammals. Most of the traditional cholesterol comes from animal brainstem and lanolin, which is of animal origin and has the risk of carrying animal viruses. Biopharma PEG innovatively uses plant sterols as starting materials to prepare plant-derived cholesterol (CAS NO.: 57-88-5) through biological ...
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Effects of tobacco (smoking and snuffing) in type 2 diabetic patients
The present study aimed to evaluate the effects of tobacco on different biochemical and physical parameters in type 2 diabetic subjects from Dera Ismail Khan, NWFP, Pakistan. A total of 100 chronic type 2 diabetic patients of different age and sex with no tobacco addiction and with tobacco addiction were requested to volunteer their complete biodata on a given Performa. Blood biochemical ...
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Abstract 9761: Novel Modulators of Low Density Lipoprotein Receptor Metabolism
Abstract Intervention with drugs to reduce Low Density Lipoprotein-cholesterol (LDL-C) has proven to decrease the risk of subsequent cardiovascular events, including mortality. Our goal is to develop novel, small molecule, LDL-C lowering drugs by targeting the Low Density Lipoprotein Receptor (LDLR) degradation pathway, which is modulated by the protease proprotein convertase subtilisin-like ...
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Function and Detection of Bile Acids
What is Bile Acid? Bile acids are the main components of bile and are synthesized in the liver from cholesterol through a series of enzymatic reactions. Bile acids can be divided into free bile acids and conjugated bile acids according to their structures. Free bile acids include bile acids, goose deoxycholic acid, deoxycholic acid and lithophanic acid. The above free bile acids are combined ...
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Abstract 10306: Identification and Characterization of Orally Bioavailable Small Molecule Protease Proprotein Convertase Subtilisin-like Kexin Type 9 Inhibitors (Best of Basic Science Abstract)
Abstract Intervention with drugs to reduce low density lipoprotein-cholesterol (LDL-C) has proven to decrease mortality and morbidity. Here, we report the development of small molecules that lower LDL-C by targeting the LDL-receptor (LDLR) degradation pathway, which is modulated by the protease proprotein convertase subtilisin-like kexin type 9 (PCSK9). PCSK9 is synthesized as a 72-kDa zymogen ...
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Copper in human health
Copper is an essential mineral for human health and at the same time can be toxic, depending upon the amounts ingested. Copper is associated with bone health, immune function and increased frequency of infections, cardiovascular risk and alterations in cholesterol metabolism. Its metabolism is tightly intertwined with other microminerals and its deficiency is known to impair iron mobilisation, ...
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Associations between perfluoroalkyl compounds and immune and clinical chemistry parameters in highly exposed bottlenose dolphins (Tursiops truncatus)
Perfluoroalkyl compounds (PFCs) are ubiquitous, persistent chemical contaminants found in the environment, wildlife, and humans. Despite the widespread occurrence of PFCs, little is known about the impact these contaminants have on the health of wildlife populations. We investigated the relationship between PFCs (including Σperfluorocarboxylates, Σperfluoroalkyl sulfonates, perfluorooctane ...
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Vitamins: Types and Their Functions
Vitamin A: Helps body growth and tissue repair, helps with eye health, fights bacteria to avoid infection, protects epithelial tissue health, and promotes bone and tooth development. Vitamin B1: Promotes the metabolism of carbohydrates, maintains a healthy nervous system, stabilizes appetite, stimulates growth and maintains good muscle condition. Vitamin B2: Promotes the metabolism of ...
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The scientific basis for probiotic strains of lactobacillus
The concept of using Lactobacillus species for disease treatment and prevention as well as health restoration and maintenance is not new. However, in recent times, there has been a renewal of interest in the use of probiotics (as distinct from antibiotics) (also termed biotherapeutic agents), driven in large part by consumers and the lay press. Probiotics have been used therapeutically to ...
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8 Health Benefits of Taking Probiotics
Probiotics refer to a certain number of live microorganisms that can have a beneficial effect on the health of the host. At present, there are more than 20 kinds of probiotics used in China, mainly including Bifidobacterium, Lactobacillus, Clostridium butyricum, Saccharomyces boulardii, Enterococcus, Bacillus licheniformis and Bacillus cereus. Probiotics have eight major functions. 1. Maintain ...
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Abstract 15053: New Insights into the Development of the Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists
Abstract Protease proprotein convertase subtilisin-like kexin type 9 (PCSK9) is an important target for the treatment of hypercholesterolemia. PCSK9 is synthesized as a zymogen that undergoes autocatalytic processing and secretion. Secreted PCSK9 binds to the LDL-receptor (LDLR) and chaperones it to the degradation pathway. Several pharmaceutical companies have developed injectable mAb PCSK9 ...
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What Are Lipids?
Lipids are hydrocarbon-containing molecules that make up the structure and function of living cells. Lipids include fats, oils, waxes, certain vitamins (such as vitamins A, D, E, and K), hormones, and most cell membranes that are not composed of proteins. Lipids are insoluble in water because they are non-polar, but are therefore soluble in non-polar solvents such as chloroform. What are lipids ...
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Estimation of stones in gallbladder with FT-IR | JBES Journals
By: Ali Ibrahim Shar, Gul Afshan Soomro, Ghulam Abbas Shar, Muhammad Bachal Korai Abstract Forty (40) specimens of the gallstones were taken from the infected peoples who were admitted and cured in the Peoples University of Medical & Health Sciences for Women, Shaheed Benazirabad, Nawabshah, Sindh, Pakistan. In our work gallstones (total 40) were found in the age ranges from 20-60 years for ...
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Dietary fibre and human health
Food habits of new lifestyle have contributed to the appearance of chronic diseases such as obesity or cardiovascular diseases, which are mainly due to bad eating habits. Solutions can be found in providing the consumers with functional foods and health capability. Such food is rich in dietary fibre, with specific physicochemical behaviour and healthy properties. Dietary fibre rich food products ...
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Liver function assessment in workers exposed to vinyl chloride
Objective: To investigate liver function in vinyl chloride workers and assess its relation with current/past occupational exposure to vinyl chloride monomer (VCM). Methods: A medical examination including the execution of liver function tests (LFTs) and liver ultrasonography was executed in a group of 757 workers with a long-standing service in the production of VCM/polyvinylchloride (PVC). ...
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Immune cells in Chernobyl radiation workers exposed to low dose irradiation
Immune response parameters were studied in Chernobyl radiation emergency workers exposed to low-dose irradiation during 1986–1989 and nuclear industry workers exposed under professional limits. Analysis was performed in irradiation dose limits of 250 and 100 mSv. The comparison group included participants of the clinical–epidemiological registry (n – 42,000) studied in the same time periods. The ...
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Akkermansia muciniphila - Preclinical studies
A large body of evidence suggests that Akkermansia muciniphila may help protect against specific metabolic disorders and cardiometabolic risk factors associated with a low-grade inflammatory status. Indeed, preclinical studies performed in diet-induced obese mice revealed very interesting beneficial effects linked to the daily oral administration of Akkermansia muciniphila. Giving the ...
By A-Mansia
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121 - Development of Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists
Abstract Protease proprotein convertase subtilisin-like kexin type 9 (PCSK9) is an important target for the treatment of hypercholesterolemia. Several pharmaceutical companies have focused on the development of mAbs. Yet, our approach has focused on developing orally bioavailable small molecule antagonists. PCSK9 is a serine protease that is synthesized as a zymogen that undergoes autocatalytic ...
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Nonalcoholic Fatty Liver and How Fucoxanthin Might Help
Many may not have heard of nonalcoholic fatty liver (NAFL) yet it is a very common condition. If NAFL is not addressed, it can progress to a serious condition known as Nonalcoholic fatty liver disease (NAFLD) Non-alcoholic fatty liver is the buildup of extra fat in liver cells that is not caused by alcohol. It is normal for the liver to contain some fat. However, if more than 5% -10% percent of ...
By Algatech
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