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Chromatograph Articles & Analysis: Older

16 articles found

Precise Determination Methods for Collagen Protein Content

Precise Determination Methods for Collagen Protein Content

The content of collagen can be accurately determined by comparing the chromatographic peaks of unknown samples with those of standard products with known concentrations.SpectroscopyUltraviolet-visible (UV-Vis) absorption spectroscopy can be used to measure the concentration of collagen, as proteins absorb ultraviolet light at specific wavelengths (such as 280nm). ...

ByMtoZ Biolabs


Determination of Monosaccharide Content and Types in Recombinant Protein Vaccines

Determination of Monosaccharide Content and Types in Recombinant Protein Vaccines

By comparing the retention times of different monosaccharides on the chromatographic column, the types of monosaccharides can be identified. Mass spectrometry can provide more detailed information about the monosaccharides, including the exact mass, structure, and connection method of the monosaccharides. ...

ByMtoZ Biolabs


Determination of Collagen Protein Content in Liquid Phase

Determination of Collagen Protein Content in Liquid Phase

Enzymatic HydrolysisProteolytic enzymes are used to further break down collagen into peptides or amino acids, which helps to improve its resolution and detection sensitivity in LC.3. Chromatographic AnalysisSelect appropriate chromatographic columns (such as reverse phase columns) and mobile phases (such as water/acetonitrile or water/methanol gradient) to ...

ByMtoZ Biolabs


How to Test the Content of Collagen Protein

How to Test the Content of Collagen Protein

Hydroxyproline Content Determination(1) Collagen is rich in hydroxyproline, thus, the collagen content can be indirectly calculated by determining the hydroxyproline content of a sample.(2) This method typically involves acid hydrolysis of the sample to release the amino acids which are then analyzed using an amino acid analyzer or chromatographic techniques.2. Specific Staining ...

ByMtoZ Biolabs


Metabolomics Technologies in Medical Research

Metabolomics Technologies in Medical Research

NMR spectroscopy does not require chromatographic processing. Sample preparation is simple and can be repeated multiple times. ...

ByCreative Proteomics


Bile Acid: A Comprehensive Exploration of Function and Metabolism

Bile Acid: A Comprehensive Exploration of Function and Metabolism

In GC-MS, bile acid samples undergo vaporization and gas-phase separation within the chromatograph. Subsequently, the gas-phase components are introduced into the mass spectrometer for ionization and analysis. ...

ByCreative Proteomics


What are Host Cell Proteins and Its Effect on Biopharmaceutical Development

What are Host Cell Proteins and Its Effect on Biopharmaceutical Development

In addition, as the purification cycle increases, HCPs can accumulate on the surface of the Protein A resin, thereby contaminating the chromatographic resin, resulting in reduced column performance and shortened lifetime. ...

ByCreative Proteomics


Eight Commonly Used Techniques for Drug Analysis

Eight Commonly Used Techniques for Drug Analysis

Chromatography Chromatography is a means of separation and analysis. The main chromatographic detection techniques include gas chromatography, liquid chromatography, and thin-layer chromatography. ...

ByCD Formulation


Everything You Want to Know About Horseradish Peroxidase

Everything You Want to Know About Horseradish Peroxidase

HRP in different activities 1) RZ > 3 activity > 250 u/mg, mainly used in immunology, is a high purity peroxidase. Special chromatographic purification techniques are used to remove isozyme B which can affect immunological reactions. (2) RZ > 2 activity > 180 u/mg is mainly used in clinical chemistry, but some of the customers have also used this size product in ...

ByCreative Enzymes


The Potency Determination of 15 Cannabinoids using the Hemp Analyzer

The Potency Determination of 15 Cannabinoids using the Hemp Analyzer

This study optimizes a quantitative chromatographic determination of 15 cannabinoids using the Shimadzu Hemp ...

ByShimadzu Scientific Instruments Inc


Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis

Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis

The organic layer was collected and analyzed using an Agilent 7890A gas chromatograph (Agilent Technologies, Santa Clara, CA, USA) under the following conditions; 1.5 kV of capillary voltage. ...

ByKoBioLabs


3 Reasons for Biopharmaceutical Labs to add Mass Detection to Routine Analyses

3 Reasons for Biopharmaceutical Labs to add Mass Detection to Routine Analyses

The ACQUITY QDa mass detector, which can be used by chromatographers with their existing bioseparations systems, allows these labs to collect their own mass data in a compliant manner, leading to streamlined workflows and faster time-to-results. ...

ByWaters Corporation


LC/MS/MS analysis of metabolites of synthetic Cannabinoids JWH-018 and JWH-073 in Urine

LC/MS/MS analysis of metabolites of synthetic Cannabinoids JWH-018 and JWH-073 in Urine

Abstract A liquid chromatographic method was developed to resolve a comprehensive set of metabolites of JWH-018 and JWH-073. ...

ByRestek Corporation


An overview of post-column derivatization methods from a pharmaceutical applications perspective

An overview of post-column derivatization methods from a pharmaceutical applications perspective

The detected signal, in conjunction with a reproducible retention time for a chromatographic method, is usually sufficient to identify and (with an appropriate set of calibration standards) quantify each analyte of interest. ...

ByPickering Laboratories, Inc.


Testing of Pharmaceutical & Cosmetic Raw Materials & Final Product Formulations for CODEX, USP/NF & BP Regulations

Testing of Pharmaceutical & Cosmetic Raw Materials & Final Product Formulations for CODEX, USP/NF & BP Regulations

To insure the consistency of the data from material tested by these guidelines, these agencies provide a number of BASIC requirements for the Instrumentation (spectrometers, chromatographs, software) and Sample Handling (collection, storage, preparation). ...

ByBuck Scientific Inc


High throughput HPLC/MS purification in support of drug discovery

High throughput HPLC/MS purification in support of drug discovery

Recovery studies have proven the reliability of this process and development of fast chromatographic separations provide enhanced throughput without additional capital investment. ...

ByAura Industries Inc.

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