Chronic Chagas Disease Articles & Analysis
99 articles found
ELANE, or neutrophil elastase (NE), is a serine protease stored in the azurophilic granules of neutrophils and is encoded by the ELANE gene on chromosome 19. It plays a pivotal role in the host defense system by degrading bacterial proteins, remodeling extracellular matrices, and shaping inflammatory responses. However, the same proteolytic activity that protects against pathogens can, when ...
Matrix Gla Protein (MGP) is a small, vitamin K-dependent extracellular matrix protein that plays a critical role in the regulation of vascular calcification and bone development. As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study ...
National No Smoking Day is observed in the UK annually on the second Wednesday of March, falling on the 12th of March 2025. Inaugurated on Ash Wednesday in 1984, the day aims to raise awareness of the dangers of smoking and encourage smokers to quit, highlighting the benefits of a smoke-free life. Smoking poses serious health risks, affecting nearly every organ in the body. Smokers significantly ...
Nicotinamide adenine dinucleotide (NAD) and its reduced form (NADH) are essential coenzymes involved in a wide array of cellular metabolic processes. As critical mediators in oxidation-reduction (redox) reactions, NAD/NADH plays a pivotal role in energy production and cellular metabolism. Understanding and analyzing these biomolecules has become increasingly important in areas such as disease ...
Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme extracted from the intestines of the silkworm, Bombyx mori. It has gained considerable interest in both the medical and wellness communities for its potential therapeutic benefits, particularly in promoting pain relief, reducing inflammation, and aiding tissue healing. Understanding serrapeptase and its applications can shed ...
Elastase is a powerful enzyme that plays a critical role in various biological processes, both in physiological and pathological contexts. It belongs to the family of serine proteases, which are enzymes characterized by a unique serine residue in their active site. This enzyme is known for its ability to degrade elastin, a key protein that provides elasticity and resilience to tissues such as ...
Drug antibody testing is a laboratory testing method specifically designed to evaluate the immune response of the human body to certain drugs. This test is commonly used to monitor a patient's immune response to biological agents or other drugs, especially in the treatment of chronic diseases such as autoimmune diseases, certain cancers, and inflammatory diseases. The principle of drug antibody ...
Structure of Matrix Metalloproteinase (MMP) Family In vertebrates, the MMP family consists of 28 members, at least 23 of which are expressed in human tissues, 14 of which are expressed in the vascular system. MMPs are usually classified into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs based on their substrates and the organization of their ...
Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of diabetes is increasing year by year. Diabetes has various types and requires long-term treatment. Antidiabetic drugs are essential for people with the disease. These drugs can be classified into insulin ...
Evaluating the stress related effects of various restraint methods in rodents Any restraining device used in an inhalation exposure set-up will be, by definition, restricting the subject’s ability to move. For nose-only inhalation set-ups, typical restraints are rigid, fully enclosed and include a metal or acrylic plunger forcing the subject forward and preventing the subject from ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
What is cystic fibrosis? Cystic fibrosis (CF) is a rare genetic disorder that affects the lungs, digestive system, and other organs. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a protein that regulates chloride ions transport across cell membranes. These mutations cause the CFTR protein to be either absent or not function ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. These models facilitate the study of disease pathology, identifying underlying mechanisms, and developing potential treatments. In the context of respiratory diseases, numerous models have been developed, with a prominent ...
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. In China, there are more than 114 million adults with diabetes, accounting for about a quarter of the world's diabetes patients. With the change of living and eating habits, diabetes has become the third major factor affecting human health after ...
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple ...
It cannot be denied that the healthcare sector is evolving quickly due to development and technological advancements. The creation of remote patient monitoring (RPM) systems and apps is a result of this. Healthcare providers can remotely monitor and examine patient health data thanks to remote patient monitoring systems. This provides people with convenience and easy access to healthcare. ...
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases. The human genome contains approximately 3 billion base pairs of DNA. Among them, only about 30 ...
Did you know that almost 36 million people in the EU live with a rare disease and the number goes up to 350 million worldwide? These diseases are an important cause of chronic illness, disability, and premature death in children as well as adults. A rare disease is any disease that affects a very small percentage of the population. It has no single accepted definition; however, countries ...
Medical History A 55-year-old white male has degenerative arthritis of the knees. 10 months ago, the patient underwent total knee replacement on the left knee without complication. The surgical incisions had closed without signs of surgical site infection. At the time, he made a good recovery. He is fully functional and fully independent. Patient is a chain smoker with a wife and two children. He ...
Medical History Jane is a 40-year-old, married mother of two teenage boys. She teaches at the local elementary school and has been in good health for most of her life. She has no surgical history. Her most severe ailment up to this point has been the flu at age 27. Her students are first-graders; they are often difficult to control. She also experiences the normal stresses of raising ...