clinical application Articles
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Biochemical and Clinical Applications of Glucose Oxidase (GOD)
Glucose oxidase (GOD) is a typical oxidoreductase found in honey and molds such as Penicillium notatum. It can highly specifically catalyze the β-D-glucose reaction to generate gluconic acid, which has the function of converting glucose and removing oxygen. Since GOD can quantitatively generate hydrogen peroxide, it is widely used in the field of biochemistry and clinical examination as a ...
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Evolutionary, Medical, and Clinical Applications of Whole Exome Sequencing
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiology, diagnosis, and treatment of certain diseases. The human genome contains approximately 3 billion base pairs of DNA. Among them, only about 30 ...
By CD Genomics
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The Future of Quantitative Susceptibility Mapping (QSM) in Clinical Applications
The use of Quantitative Susceptibility Mapping (QSM) is often viewed as incompatible with current standard radiology workflows. Some radiologists or departments may be unaware of its existence or purpose. Despite the skepticism surrounding its viability in a clinical setting, QSM shows great potential in a wide range of clinical applications, particularly for biomarker detection and ...
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Lehigh Valley Health Network: External Beam Electron Treatment with 3D Printed Modulated and Simple Bolus - Case Study
This patient case demonstrates the clinical application of Adaptiiv’s technology used in radiation oncology through the design and fabrication of both modulated and uniform thickness (simple) ...
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Targeted Region Sequencing in Human Disease Studies and Clinical Care
Introduction to target region sequencing Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers to obtain whole genome or targeted regions of samples. Targeted region sequencing is preferred by ...
By CD Genomics
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Potentials of transforming growth factors alpha and beta-1 in predicting the clinical outcome of bladder carcinoma
The 'protein traffic hypothesis' suggests that the inflammation associated with autoimmune disease, trauma and disturbances of blood circulation is the result of misguided protein trafficking. The hypothesis divides the antigen spectrum into an intracellular component and an extracellular component. While the intracellular component is recognised by MHC class-I molecules and is presented to CD8 ...
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Experimental confirmation of the `protein traffic hypothesis` by routine diagnostic tests
The 'protein traffic hypothesis' suggests that the inflammation associated with autoimmune disease, trauma and disturbances of blood circulation is the result of misguided protein trafficking. The hypothesis divides the antigen spectrum into an intracellular component and an extracellular component. While the intracellular component is recognised by MHC class-I molecules and is presented to CD8 ...
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Molecular imaging with targeted quantum dot bioconjugates: the need for contrast optimisation studies
Quantum dots have the potential to be used as contrast agents for molecular imaging in vivo, but there are many challenges in optimising such procedures, both in pre-clinical animal models and in the potential clinical applications. In particular, it is critical to obtain the optimal target-to-background contrast to achieve maximum diagnostic accuracy. However, available data are insufficient to ...
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Combination of high efficiency nano–silver and alginate for wound infection control
Numerous chemical and physical methods have been employed to prepare metal nanoparticles, including chemical reduction. Silver has been known to have potential for bactericidal properties and promotion of wound healing. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. We used chemical reduction for preparation of ...
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Dosimetry analysis of two new design 103 Pd interstitial brachytherapy sources
With increased demand for low 103 Pd (palladium) seed sources, to treat prostate and eye cancers, new sources have been designed and introduced. This paper presents the two new palladium brachytherapy sources, IR03- 103 Pd and IR04- 103 Pd that have been developed at Agricultural, Medical & Industrial Research School . The dosimetric parameters, such as the dose rate constant Λ , ...
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Editorial: Quantitative Susceptibility Mapping in Neurodegeneration
Introduction Magnetic resonance imaging offers a wide variety of contrast mechanisms to study soft tissue in the body. Using the complex data from the SWI scans, it is possible to produce magnetic source images using a novel reconstruction method that takes the phase data and reconstructs what is referred to as a quantitative susceptibility map (QSM). The phase images represent local frequency ...
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Nuclea Launches Strategic Partnership with Aelan in Field of Epigenetics
CAMBRIDGE, MA--(Marketwired - Jun 30, 2015) - Nuclea Biotechnologies Inc. announced today that it is partnering with Aelan Cell Technologies Inc. (San Francisco, California) for the development, validation and commercialization of novel biomarker tests and companion diagnostics using human STEM cells as models. Their collaboration has the potential to impact disease monitoring and drug ...
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Aelan Cell Technologies Adds Human Embryonic Stem Cell Expert Meenakshi Gaur, Ph.D. to Stem Cell Clinical Program
SAN FRANCISCO, CA--(Marketwired - Sep 11, 2015) - Aelan Cell Technologies announced today the addition of Meenakshi Gaur, Ph.D. to their stem cell clinical program. Dr. Gaur will serve as the Director of Research and Development of the Stem Cell Program, leading a research team that will develop technology aimed at rejuvenation of human mesenchymal stem cells for clinical applications. "Dr. Gaur ...
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Do You Really Know Hydroxyapatite?
As an important branch of biomedical materials, bioceramics are mainly used to manufacture hard tissue repair devices and artificial organs in vivo, and generally have good biocompatibility. According to the chemical activity in the physiological environment, bioceramics can be divided into three types: Nearly inert bioceramics, only weak or no chemical reaction occurs when exposed to the ...
By Matexcel
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Huateng Pharma Supplies Minoxidil Intermediate 2,4-Diamino-6-chloropyrimidine (CAS NO.156-83-2)
Minoxidil was first introduced by Upjohn Company of the United States, and was first used as an oral drug for the treatment of refractory hypertension in the 1970s. In later clinical applications, doctors observed hair regrowth and generalized excessive hair in balding patients, which led to the development of minoxidil preparations. Minoxidil can increase local blood supply, stimulate the ...
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Summary of new EU Clinical Trial Regulation
The changes the regulation brings companies need to already be reviewing their current processes, systems and supporting infrastructure for clinical trial applications and operations. They need to do so in every changing regulatory environment where Clinical Trial and related data is being ever more scrutinized. This paper provides a synopsis of the new regulation Insights on timing The ...
By DDi LLC
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What Are the Applications of Enzymes in Disease Research and Treatment?
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive. 1. The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or ...
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OneThree’s Workflow for Identifying Synergistic Drug Combinations - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
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Has the future of complement therapeutics arrived?
Silence Therapeutics, a pioneer in the development of novel small interfering RNA (siRNA) therapeutics, and Mallinckrodt plc, a global biopharmaceutical company, announced the submission of a clinical trial application (CTA) for SLN501, a siRNA therapy targeting the complement C3 protein, on March 23, 2022. Silence will receive a $3 million milestone payment from Mallinckrodt as a result of the ...
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Uses of Recombinant Human Collagen
Collagen is the main structural protein in vertebrates. It plays an essential role in providing a scaffold for cellular support and thereby affecting cell attachment, migration, proliferation, differentiation, and survival. Natural animal collagen and its recombinant collagen are favorable replacements in human tissue engineering due to their remarkable biomedical property. However, this ...
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