clinical assessment Articles
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Pulse Oximetry with Clinical Assessment to Screen for Congenital Heart Disease in Neonates in China: A Prospective Study - Case study
Background Several pioneering studies have provided evidence for the introduction of universal pulse oximetry screening for critical congenital heart disease. I lowever, whether the benefits of screening reported in studies from high-income countries would translate with similar success to low-income countries is unknown. We assessed the feasibility and reliability of pulse oximetry plus clinical ...
By Masimo Corp
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Dynamic process modelling of patients` no-show rates and overbooking strategies in healthcare clinics
Abstract: Clinic appointment cancellation and 'no-shows' by patients can disturb day-to-day scheduling and lead to inefficient resource allocation and lost revenue. This paper presents an approach for dynamic process modelling and analysis of patients' no-show rates in conjunction with the overbooking strategy. To this end, a dynamic discrete event simulation model of a clinic operation is ...
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Dynamic process modelling of patients' no–show rates and overbooking strategies in healthcare clinics
Clinic appointment cancellation and 'no–shows' by patients can disturb day–to–day scheduling and lead to inefficient resource allocation and lost revenue. This paper presents an approach for dynamic process modelling and analysis of patients' no–show rates in conjunction with the overbooking strategy. To this end, a dynamic discrete event simulation model of a clinic ...
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Project - T-Pin Case Registry
We continue to assess the outcomes of T-Pin cases in the orthopaedic surgery community. We are seeking qualified surgeons to collect outcome data for patients whose fractures have been treated with the T-Pin System. Subjetive and objective assessment of factors such as patient selection factors, intraoperative observations and clinical pearls, and postoperative assessment will be ...
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How eCOA Improves Patient Experience and Data Quality
With the rising demand for improving patient safety in clinical trials, the adoption of patient-centric solutions is considered the best route to enhance data accuracy and experience automated workflows. This is where eCOA comes into play. In this blog post, we will find out how electronic clinical outcome assessments are helping the clinical trials industry handle the ever-growing list of ...
By Clinion
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Are clinicians delivering the best care for patients with bladder and bowel dysfunction? A recent study suggests otherwise
People with neurogenic bladder and/or bowel dysfunction often suffer from highly individualized symptoms. It can be difficult to quantify change in an individual’s symptoms using standardized measurement tools, and points to the value of Patient—Centered Outcome Measures. As a relatively new concept, Patient—Centered Outcome Measures (PCOM) aims to place patients, their ...
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Diagnostic yield of automatic and patient-triggered ambulatory cardiac event recording in the evaluation of patients with palpitations, dizziness, or syncope.
BACKGROUND: Recent studies have shown that patient-triggered cardiac event recorders (CER) have an increased diagnostic yield and are more cost effective than conventional 24-h-Holter electrocardiograms (ECGs) for the evaluation of sporadic, potentially arrhythmia-related symptoms. HYPOTHESIS: The aim of this study was to determine the diagnostic yield of a patient-triggered CER combined with ...
By Novacor
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Why open-source AI platforms are the future of patient health tracking in clinical trials
Imagine you’ve just been diagnosed with cancer and you’re enrolled in a clinical trial for a promising new drug. You notice that after chemotherapy you struggle with occasional fatigue. Yet, whenever you visit your doctor every couple of weeks, you feel fine. This is not only a frustrating experience for patients, but it can also compromise the safety data in a clinical trial. The ...
By AiCure
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Preliminary Examination of the Ability of a New Wearable Device to Capture Functional Hand Activity After Stroke
Background and Purpose— A reliable measure of movement repetitions is required to assist in determining the optimal dose for maximizing upper limb recovery after stroke. This study investigated the ability of a new wearable device to capture reach-to-grasp repetitions in individuals with stroke. Methods— Eight individuals with stroke wore an instrumented wrist bracelet while ...
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Long-Term Outcomes Following Lumbar Nucleus Replacement
Abstract Background Nucleus replacement devices are designed to replace the native pain-generating lumbar nucleus while preserving the annulus fibrosus, endplates, and natural motion. The DASCOR Disc Arthroplasty Device seemed to perform well clinically but was discontinued in 2009. While there are no commercially available NRDs today, the potential advantages of using such devices have ...
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A Comprehensive Analysis of Cell and Gene Therapy
The scientific realm of biomedicine has witnessed extraordinary evolution in recent years, particularly in the spheres of cell and gene therapies. These therapies have radically revamped disease treatment modalities, transcending traditional approaches to become some of the most groundbreaking advancements in modern healthcare. This article aims to engage in an incisive analysis of cell and gene ...
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What is heart failure with preserved ejection fraction (HFpEF)?
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
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What Clinical Trial Speed Factors Can Sponsors Actually Control?
When promising drug candidates are identified for further investigation in clinical trials, sponsor companies are usually optimistic about outcomes. But there are times, when after years of sunk effort and resources, clinical trials fail to bring a viable drug to market. Frequently, a drug fails for safety or efficacy reasons that are beyond a sponsor’s control. However, to some degree, ...
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Through a Simple Blood Test, Our Body’s Gut Bacteria Can Help Detect Early-stage Colorectal Cancer
Analysis of microbiome signatures in plasma for early CRC detection Colorectal cancer (CRC) represents the 3rd leading cause of cancer-related deaths in the United States. Patients diagnosed with distant stage of the disease represent 22% of all CRC cases and have 15% 5-years survival rates, in contrast to 91% 5-years survival rate of patients with localized disease at diagnosis, indicating how ...
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Summary of new EU Clinical Trial Regulation
The changes the regulation brings companies need to already be reviewing their current processes, systems and supporting infrastructure for clinical trial applications and operations. They need to do so in every changing regulatory environment where Clinical Trial and related data is being ever more scrutinized. This paper provides a synopsis of the new regulation Insights on timing The ...
By DDi LLC
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Understanding the Importance of Preclinical Animal Models in Drug Development
In the world of pharmaceuticals, developing safe and effective drugs is a complex and time-consuming process. Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. One critical component of this evaluation is the use of preclinical animal models. Preclinical ...
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Application of Enzyme Detection in Clinical Diagnosis
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Bridging Clinical Research to Real-World Patient Care Through Predictive Analytics
The ability to predict how a clinical trial participant will adhere to their treatment, and even respond to that treatment, has great promise to advance patient-centric clinical research. But, as we look to understand the impact a drug has on patients’ everyday health outside of a research environment, what happens to these unique, predictive findings around dosing and outcomes once a drug ...
By AiCure
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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