clinical diagnosis Articles
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Biomedical applications of organically modified bioconjugated silica nanoparticles
Nanoparticles are one of the most important prominent areas in the field of nanotechnology, with a broad significant role in current life sciences and human healthcare applications. Among the nanoparticles silica nanoparticles are explored in many biological applications because their size dependent novel properties and functions differ drastically from those of the bulk materials. In biomedical ...
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Application of Enzyme Detection in Clinical Diagnosis
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study
Abstract Background: Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality, most of which occurs in low and middle-income countries. The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous ...
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Nature: Structure-based classification of tauopathies
Abnormal accumulation of misfolded tau in filaments is characteristic of many neurodegenerative diseases—precisely for this reason, these neurodegenerative diseases are collectively referred to as tauopathy. The Michel Goedert team and the Sjors Scheres team at the Molecular Biology Laboratory of the Medical Research Council in Cambridge, UK, witnessed the use of cryo-EM to dissect tau ...
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SNP Array, A Powerful Tool for Diagnosis and Agrigenomics Research
Single-nucleotide polymorphisms (SNPs) are a kind of DNA polymorphisms caused by single-nucleotide variants in both coding and non-coding regions, which are the most common and smallest variants. There are more than 3 million SNPs in the human genome with an average of 1 in 500-1000 base pairs. SNP microarrays are capable of detecting a large number of subtle DNA alterations and/or abnormal ...
By CD Genomics
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Biochemical and Clinical Applications of Glucose Oxidase (GOD)
Glucose oxidase (GOD) is a typical oxidoreductase found in honey and molds such as Penicillium notatum. It can highly specifically catalyze the β-D-glucose reaction to generate gluconic acid, which has the function of converting glucose and removing oxygen. Since GOD can quantitatively generate hydrogen peroxide, it is widely used in the field of biochemistry and clinical examination as a ...
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Quantifying Tissue Properties of the Optic Radiations Using Strategically Acquired Gradient Echo Imaging and Enhancing the Contrast Using Diamagnetic Susceptibility Weighted Imaging
Abstract Visualization of the optic radiations is of clinical importance for diagnosing many diseases and depicting their anatomic structures for neurosurgical interventions. In this study, we quantify proton density, T1, T2*, and susceptibility of the optic radiation fiber bundles in a series of 10 healthy control participants using strategically acquired gradient echo imaging. Furthermore, we ...
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Amplicon Sequencing for Microbiome Research: Introduction, Advantages, and Applications
The identification of microbial groups is an important step in understanding the interrelationship of microorganisms in a community. It is done to determine all present microbial taxa and their relative abundance, and as well their phylogenetic relationships. One of the methods used to establish phylogenetic relationships is by sequencing common genes. One of the easiest genes to be sequenced are ...
By CD Genomics
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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The impact of variability in the risk of disease exemplified by diagnosing diabetes mellitus based on ADA and WHO criteria as gold standard
The diagnosis of clinically mute diabetes mellitus (DM) is based on a nominal concentration of fasting peripheral venous plasma glucose (f-vPG) at ≥7.0mmol/l, to be exceeded by first and confirmatory measurement. Aim: to identify error sources in the clinical use of biochemical data, to use the diagnostic concept for clinically mute DM. Materials and methods: error contributors were established. ...
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What is FGL2?
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
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Prevalence of plastic additives in indoor air related to newly diagnosed asthma
This paper presents a correlation between the certain plastic additives and newly diagnosed asthma. We studied this association by measuring the plastic additives in the indoor air of the homes of presenting patients at the Skin and Allergy hospitals, including old and new, clinically diagnosed cases of asthma and controls. A total of 465 people filled in a questionnaire that probed, for example, ...
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Beyond Insulin: Immunotherapy for Type 1 Diabetes-PI
Type 1 diabetes (T1D) is a complex T-cell-mediated autoimmune disease that results in the destruction of insulin-producing beta cells and inadequate insulin secretion. Prior to the discovery of insulin in 1921, patients with T1D died within a year or two of diagnosis. Since the discovery and mass production of insulin, T1D is no longer a terminal disease. However, over time, many patients still ...
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Comparison Between Illumina and Nanopore Sequencing Technologies
What is Illumina Sequencing? Illumina sequencing is a second-generation sequencing technology that has become a powerful tool for genomics research. The method uses reversible dye terminator technology to detect the sequence of a DNA molecule. The process begins by fragmenting the DNA sample into short fragments, typically 100-150 base pairs (bp) in length. These fragments are then ligated to a ...
By CD Genomics
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Israeli hospital pilots rapid diagnostics of blood cancer with Sight Diagnostics
Israeli-founded firm Sight Diagnostics, the company that uses AI and cutting-edge hardware to deliver rapid, complete blood count results, has signed a new research agreement with Jerusalem’s Shaare Zedek Medical Center to identify the possibility of blood cancer using a combination of images and data collected from Sight’s OLO device and patient clinical information provided by the ...
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Nanostics Re-Opens ClarityDX Prostate Clinical Study with New US Recruitment Site
Summary Nanostics' clinical validation study for ClarityDX Prostate, a liquid biopsy test for the early diagnosis of clinically significant prostate cancer, re-opens recruitment after lifting of COVID-19 research restrictions A top-ranked research institute in the Northeast US will now partner with Nanostics' by recruiting patients for the clinical validation study This partnership will ...
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How Whole Exome Sequencing Works: Principles and Workflow Demystified
As the development of biological experimental technology, especially gene-sequencing technology, both laboratory and clinical researchers realize that genome sequencing is the best way to analyze the etiology, pathophysiology, treatment and prognosis of diseases. Researches further demonstrate that there are only 30 million base pairs of genes that contain essential information of proteins for ...
By CD Genomics
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Detailed Introduction to Clinical Significance of Amylase
As a kind of enzymes for diagnostic use. Serum amylase (AMS) is the main type of amylase in serum. It belongs to glycoside chain hydrolase, which is mainly derived from the pancreas. In addition, there are also a small amount of secretion in the proximal duodenum, lung, uterus, and breast during lactation. Amylase plays an important role in the digestion of polysaccharide compounds in food. The ...
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Diagnosing heart failure with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine, overtaking heart failure with reduced ejection fraction (HFrEF) and becoming the most common form of heart failure, with a prevalence that is increasing by 1% annually.[1] Despite this, there remains no gold standard in diagnosing HFpEF. Diagnosing ...
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High School Sports Concussions - Case Study
High School Sports Concussions Lucy, a 15-year-old female is competing in a karate tournament a few hours from her home. She is a black belt and has been working very hard to place in the tournament. While in the semi-final match, she was caught with a round-house kick to her head. She was wearing headgear and she did not get knocked down. Following the match, which she lost, her parents and her ...
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