clinical need Articles
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Electrospun nanofibres of polycaprolactone, and their use for tendon regeneration
Inferior scar tissue formed when injured tendons heal often results in ongoing pain and site morbidity. With current treatments being ineffective, there is a clinical need for a tissue engineered approach. Electrospinning produces nanofibres with morphologies and architectures similar to the natural extra cellular matrix. Research incorporating electrospinning for tendon regeneration is limited. ...
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What to know of when searching for the best family chiropractor!
It is likely to see many people nowadays suffering from various kinds of physical health issues. These problems may be due to a number of reasons such as sports injuries, old age or else. Regardless of what health issue one may be experiencing, it is important to seek the needed help in order to recovery easily. Many people in today’s world therefore seek the aid of a professional ...
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Characterization of a Novel 3 MegavoltLinear Accelerator for DedicatedIntracranial Stereotactic Radiosurgery
Abstract The purpose of this article is to investigate and characterize from a physics perspective theZap-X (ZAP Surgical Systems, Inc., San Carlos, CA), a new, dedicated self-contained and self-shielded radiosurgery system, focusing on beam energy and performance, leakage, radiationsafety, dose delivery accuracy, regulations, quality assurance, and treatment planning. Thisinvestigation is ...
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IV safety valve dev Linear Health wins GCMI accelerator grant – Via MassDevice
Linear Health Sciences was featured in MassDevice focused on the GCMI/LHS Partnership Medical device accelerator the Global Center for Medical Innovation has issued its 1st grant to Linear Health Sciences, developer of the Orchid safety release valve designed to prevent dislodgment of IVs. The Oklahoma City-based company said it is developing safety release valves for a variety of medical ...
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Robotics startup Vicarious files pre-submission with FDA, fresh from $220M SPAC raise
Vicarious Surgical has filed a pre-submission with the FDA, marking the start of a regulatory process it hopes will lead to a 510(k) application by late 2023. Dive Brief: Vicarious Surgical has filed a pre-submission with the FDA, marking the start of a regulatory process it hopes will lead to a 510(k) application by late 2023. The filing, which Vicarious disclosed in its first quarterly ...
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Through a Simple Blood Test, Our Body’s Gut Bacteria Can Help Detect Early-stage Colorectal Cancer
Analysis of microbiome signatures in plasma for early CRC detection Colorectal cancer (CRC) represents the 3rd leading cause of cancer-related deaths in the United States. Patients diagnosed with distant stage of the disease represent 22% of all CRC cases and have 15% 5-years survival rates, in contrast to 91% 5-years survival rate of patients with localized disease at diagnosis, indicating how ...
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Essential Clinical Trial Systems for Small, Midsize, and Large Pharma
Revisiting the “why” behind decision making can be a helpful exercise in all aspects of business. This is no less true for clinical operations executives when it comes to the clinical trial systems they employ to facilitate their teams’ work. The technology that supports clinical trial systems has evolved steadily over the past several decades, yet the ultimate goal of ...
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Nanostics is Developing and Validating a Simple Blood Test to Predict Severity of COVID-19 Disease in SARS-CoV-2 Positive Patients
Edmonton, Alberta - Nanostics Inc., a diagnostic healthcare company that focuses on developing tests to determine a patient's disease risk, announced today plans to develop and validate ClarityDX COVID-19; a simple blood test to predict the severity of COVID-19 disease in patients. Nanostics, in collaboration with the Canadian BioSample Repository (CBSR) at the University of Alberta and Century ...
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Detailed Introduction to Steroids Analysis
Steroid hormone is a class of compounds that contain cyclopentane polyhydrophenanthrene structure formed by cholesterol and catalyzed by cytochrome P450 enzymes. Steroid hormones mainly include adrenocorticotropic hormones secreted by the adrenal cortex and sex hormones secreted by the gonads, which are mainly divided into four categories: progesterone, corticosteroid, estrogen and androgen. ...
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A Natural Polysaccharide-based Bioadhesive for Wound Repair Found
Hundreds of millions of people suffer skin tissue damage every year, including accidental injury, surgical injury, chronic ulcer, etc., and severe cases may lead to amputation or even life-threatening. Suturing is currently the preferred method for clinically closing wounds. However, wound suturing takes a long time during the operation, and removing the stitches will cause secondary damage to ...
By CD BioGlyco.
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BeadReady™ successfully storing cells for 3D biofabrication
Another fantastic publication highlighting one of the multiple applications Atelerix products have within the scientific research and development industry. Anastassia Kostenko , Che J. Connon, and Stephen Swioklo (2023), have successfully shown that Atelerix BeadReady™ is a simple, adaptable solution for room temperature cell storage in combination with biofabrication and how this can be ...
By Atelerix Ltd
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The Toxicity Atlas - One year later
It’s been about a year since I started my PhD project named The Toxicity Atlas. In this four-year project, I’m collaborating with researchers from Amsterdam UMC and my colleagues at Medstone to find better treatment options for patients with brain cancer. Let me tell you more about my results so far. Information databases Developing new drugs costs a lot of money and a lot of ...
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Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening
Publication Summary: Recent advances in the directed differentiation of human pluripotent stem cells to kidney organoids advances the prospect of drug screening, disease modelling, and even restoration of renal function using patient-derived stem cell lines. Here, we demonstrate the successful adaptation of our directed differentiation protocol to the NovoGen Bioprinter® MMX technology to ...
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Characteristics and Applications of Luminex Multiplex Technology
Luminex multiplex assays is a multi-functional, multi-indicator parallel analysis system that organically integrates color-coded beads, laser technology, applied fluidics, the latest high-speed digital signal processor and computer algorithms to create a high degree of specificity and sensitivity for multi-factor detection. It can be widely used in immunoassay, nucleic acid research, enzymatic ...
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Applications of Liposomal Drug Delivery System Technology
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, ...
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Nanostics Announces the Launch of its Bladder Cancer Clinical Study Identifying Disease Predictors for Early Detection of Bladder Cancer
Clinical study launched in June 2022 with patient recruitment in Alberta with plans to expand to further sites across North America. The aim of the study is to validate a novel and minimally invasive liquid biopsy test for bladder cancer diagnosis using Nanostics’ ClarityDX® diagnostic platform. The study is supported in part by the Alberta Innovates AICE-Concepts Program with a ...
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Image is Everything: MRI and Helium Safety
MRI Magnetic resonance imaging (MRI) is a diagnostic procedure that uses a combination of a very large magnet, radio waves, and a computer to produce detailed, cross-sectional, and three-dimensional images of organs and structures within the body. An MRI scan is a valuable diagnostic tool that can show injuries or other anomalies that cannot be seen in a CT scan or X-ray. For instance, soft ...
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Luminex Multiplex Assay
Principle of Luminex Multiplex Assay Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test ...
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Intracranial Neoplasms: The Evolution of Radiotherapies
CURRENT STANDARD OF CARE FOR BRAIN TUMORS The current initial standard of care for aggressive brain tumors—whether they are primary brain tumors (ie, tumors that originate in the brain), or metastatic tumors from cancers that started outside of the brain—is resection. After surgery, a follow-up treatment, also referred to as adjuvant treatment, is often recommended to help eliminate ...
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How One Smart MedTech Company is Leveraging Innovation to Save the Lives and Limbs of VTE Patients
Medical device start-up companies must focus on innovation, regulatory compliance, efficient processes and prudent financial management in order to survive. Smart MedTech companies prioritize their funding to only support innovation which will result in new products that fulfill significant unmet clinical needs over the long-term. Thrombolex, a relatively new entrant into the MedTech sector, is a ...
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