clinical response Articles
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Drug adherence in Parkinson`s disease
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor ...
By Sensidose AB
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A Bayesian design for phase I cancer therapeutic vaccine trials
Abstract Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not ...
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Clinician Attitudes are Shifting on MRD-guided Decision Making in Multiple Myeloma
This September marks four years since the 2018 Food and Drug Administration clearance for clonoSEQ to detect and monitor minimal residual disease (MRD) in bone marrow from patients with acute lymphoblastic leukemia (ALL) and multiple myeloma (MM). In the years following, researchers have explored the value of using MRD status to guide treatment in blood cancers – and the mounting ...
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Science: Knockout of this epigenetic gene gives CAR-T cells the ability to continuously attack cancer cells
Simply put, CAR-T is to transform the patient's immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells. In 2017, CAR-T therapy was first approved by the FDA for the treatment of blood cancers such as leukemia and lymphoma. ...
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Treos Bio Announces the Publication of Preclinical Data in Frontiers in Genetics Showing its COVID-19 Peptide Vaccine Mimics the Diversity of T Cell Immunity Produced by Natural SARS-CoV-2 Infection
LONDON, June 28, 2021 (GLOBE NEWSWIRE) – Treos Bio Limited (“Treos”), a clinical stage biotechnology company using data science and proprietary biomarkers to develop precision off-the-shelf and personalized peptide cancer immunotherapies, today announced the publication of a peer-reviewed article titled “A Peptide Vaccine Candidate Tailored to Individuals’ Genetics ...
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Idience: developing selective and potent PARP inhibitor IDX-1197 for solid tumors
The first wave of PARP inhibitors has improved outcomes in people with a variety of solid tumors. However, Idience has identified opportunities to improve the efficacy of existing drugs and overcome resistance. The company plans to target homologous recombination repair-proficient patients with a clinical-phase PARP inhibitor that is now available for licensing. Ildong Holdings, a major ...
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AI’s Evolving Role in Monitoring and Treating Sleep Disorders
Obstructive sleep apnea (OSA) is a serious and life-threatening condition. Approximately 5.9 million adults are diagnosed with OSA, but as many as 23 million people are estimated to be dealing with OSA yet go undiagnosed. The impact on health can be significant, ranging from inconveniences to life-threatening illnesses. Obstructive sleep apnea can cause disrupted sleep for both OSA sufferers and ...
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Going beneath the surface of skin cancer - Case study
Summary In this Cell Patterns publication, Ozette co-founders and collaborators at the Cancer Immunotherapy Trials Network (CITN) outline a novel method of analysis of single cell data, FAUST, and validate the multiple potential applications. The paper tackles 2 important problems: 1) analysis of complex single cell datasets; 2) prediction of response to immunotherapy in cancer. Manual ...
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IL-2 and IL-2 Receptor Series: Pioneering Solutions for Immunotherapy Research
Interleukin-2 (IL-2) is a 15kDa secretory protein with a 4-alpha-helical bundle structure. As a T-cell related growth factor, IL-2 can enhance the killing activity of NK cells and promote B cells to produce immunoglobulins. In addition, it aids in the development of regulatory T cells (Tregs), thereby producing peripheral T cell immune tolerance, as well as regulating the proliferation and ...
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What are Strongyloides?
Strongyloides is an opportunistic pathogenic parasitic nematode. Adults parasitize in the small intestine of cats, dogs and humans. The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. The disease is mainly prevalent in warm and humid tropical and subtropical regions. In recent years, due to the continuous increase of HIV/AIDS infection rate in ...
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Enhancing Healthcare Security: The Role of Door Frame Metal Detectors in Hospitals and Clinics
Enhancing Healthcare Security: The Role of Door Frame Metal Detectors in Hospitals and Clinics The safety and security of patients, healthcare professionals, and visitors are paramount in hospitals and clinics. With the evolving landscape of security threats, the implementation of robust security measures is essential to ensure a secure environment conducive to healing and care. Door frame metal ...
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Global ADC Drug Overview
In recent years, antibody-drug conjugates (ADCs) have been widely sought after due to their excellent clinical performance and market returns. ADC drugs are composed of three parts: antibody, effector molecule (Payload, usually cytotoxic agent) and linker. Compared with traditional drugs, ADC drugs have obvious advantages in improving targeting and reducing side effects. 1. Global ADC listing ...
By BOC Sciences
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Improved Sepsis Detection & Compliance: 6 Areas your Next Solution should Address
Sepsis accounts for over 20% of deaths worldwide (WHO) and 85% of cases occur in low-resource settings.But this isn’t a problem mostly owned by third-world countries with inadequate equipment and detection technology. In the U.S., less than 50% of patients are correctly treated for sepsis, mostly due to clinicians missing the timeline for treatment. The problem is so widespread that ...
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A new perspective regarding laser therapy
In April of this year, prior to the beginning of our International Conference in Toronto, I had the rare opportunity to meet for several hours with Tiina Karu, Mary Dyson, Shimon Rochkind, Chukuka Enwemeka and several other leading authorities involved in the field of laser technology. Whereas their interests encompass basic research, pathology, tissue response mechanisms and clinical ...
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Remote Oncology Care: Review of Current Technology and Future Directions
Abstract Cancer patients frequently develop tumor and treatment-related complications, leading to diminished quality of life, shortened survival, and overutilization of emergency department and hospital services. Outpatient oncology treatment has potential to leave cancer patients unmonitored for long periods while at risk of clinical deterioration which has been exaggerated during the COVID19 ...
By Oncodisc
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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