Clinical Response Articles & Analysis
11 articles found
It is the process that bridges the gap between basic research and clinical testing, allowing for the evaluation of potential drug candidates in biological systems before they are tested in humans. ...
In the past, clinical data managers were responsible for data entry and cleaning. In the late 90s, the role of the CDM began to change as electronic data capture (EDC) became more prevalent. ...
ByClinion
IL-2 regulates innate immune cells In humans, monocytes express IL-2R under the stimulation of IFN-γ, but only activated monocytes can bind with IL-2. During the inflammatory response, the expression of IL-2R will affect macrophage differentiation, limiting T cell proliferation and function. ...
The paper tackles 2 important problems: 1) analysis of complex single cell datasets; 2) prediction of response to immunotherapy in cancer. Manual analysis of large volumes of highly complex cytometry and other single cell data such as that generated in clinical trials is not only slow, but is biased in that investigators can generally only identify cell ...
This evolution is captured by a 2021 survey of 89 oncologists, published in Blood Cancer Journal last month, aimed at understanding clinicians’ general attitudes toward the use of MRD and how MRD status might impact decision-making in common clinical scenarios. Responses were received from oncologists who treat multiple myeloma patients in academic and ...
Bare-handed field workers or mine workers are highly susceptible to infection. The clinical symptoms vary according to the intensity of infection and the immune function of the host. ...
They confirmed that epigenetic regulation is directly involved in T cell failure, which has a great impact on the clinical response to cell therapy. The team also studied DNA methyltransferase 3α (DNMT3A) in a mouse model and in the setting of chronic viral infection. ...
“We are gratified to see these promising results published in Frontiers in Genetics, providing another scientific validation for our novel approach to match patients’ genetic background to T cell responses, which was already successfully applied for the design of our off-the-shelf cancer vaccines. We believe long-term immunity to coronaviruses will likely originate ...
Diagnosis and Detection breakthroughs Instead of clinical sleep studies, doctors are increasingly turning to AI-enhanced peripheral wrist sensors from Oxitone. ...
Abstract Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. ...
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. ...