clinical value Articles
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Scientists Find Smart Human Antibody Neutralizes Ebola and Its Deadly Relatives
A research team's latest study shows that two human antibodies can simultaneously target two Ebola viruses: Ebola and Sudan. These two species have caused the largest and deadliest outbreaks. The new report suggests that researchers could combine these two potent antibodies to create an effective antiviral therapy. The work is published in Cell in the paper, “Asymmetric and ...
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Entrepreneur in Residence
Celdara Medical, LLC (CM) is developing a portfolio of preclinical therapeutic assets, platforms, and companies. Each of these has a different development path, and we work with many different modalities, and in many different indications, but everything we do is singularly focused on saving lives and/or improving quality of life. The successful Entrepreneur In Residence will identify one or ...
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Basic Information and Application of Alcohol Dehydrogenase
Alcohol dehydrogenase is abundant in human and animal liver, plant and microbial cells. It is a zinc-containing metalloenzyme with broad substrate specificity. Alcohol dehydrogenase can use nicotinamide adenine dinucleotide (NAD) as a coenzyme to catalyze the reversible reaction between primary alcohols and aldehydes: CH3CH2OH+ NAD+→ CH3CHO +NADH+ H+. In humans and mammals, alcohol ...
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Value of BWT Measurement in Bladder Scanner
Being the first bladder scanner in the world which can measure BWT bladder wall thickness, M5 makes it possible that BWT can be monitored easily and quickly on daily basis. This feature fosters research on coorelation between BWT and different urological diseases. During the interview with Dr. Xu Kexin from Peking University People's Hospital whose team has been using M5 for about one year, we ...
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FluGen Announces Completion of First Cohort in Age De-escalation Clinical Trial of M2SR Flu Vaccine Candidate in Pediatric Subjects Ages 6 Months to 17 Years
MADISON, Wis., Sept. 7, 2022 /PRNewswire/ — FluGen, Inc., a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases, today announced the completion of enrollment of the first cohort in an age de-escalation clinical trial of M2SR (M2 Deficient Single Replication) live virus vaccine, the company’s investigational supra-seasonal intranasal ...
By FluGen, Inc.
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Techniques to Enhance Drug Solubility
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and ...
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Idience: developing selective and potent PARP inhibitor IDX-1197 for solid tumors
The first wave of PARP inhibitors has improved outcomes in people with a variety of solid tumors. However, Idience has identified opportunities to improve the efficacy of existing drugs and overcome resistance. The company plans to target homologous recombination repair-proficient patients with a clinical-phase PARP inhibitor that is now available for licensing. Ildong Holdings, a major ...
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What Are the Applications of Enzymes in Disease Research and Treatment?
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive. 1. The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or ...
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Transitioning to a single-use mindset, getting ahead of the curve
If single use devices are inevitable, the next step after “why” needs to be an understanding of “how” medtech companies and device makers can get on the right side of the movement. The move towards single use scopes and other medical devices had its start long before Covid-19, but the pandemic has accelerated this trend across the medical technology field. An emphasis ...
By Noah Medical
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Do you really have to sacrifice MRI image quality for speed?
To understand the significance of the SpinTech MRI STAGE software platform, it helps to begin by asking a question: Given that MRI is an incredibly powerful diagnostic tool for neurological diseases like Alzheimer’s, dementia, Parkinson’s and multiple sclerosis (MS), why have radiologists and neurologists had to choose between conducting faster MRI exams and obtaining higher-quality ...
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Transcutaneous Vagus Nerve Stimulation (tVNS) Enhances Divergent Thinking
Highlights of Research A clinical study investigated transcutaneous vagus nerve stimulation (tVNS). Results indicate tVNS stimulates afferent fibers of the vagus nerve; and, that tVNS enhances creativity performance in divergent thinking. Divergent thinking is a thought process or methodology that is used to generate creative ideas by exploring a number of possible solutions to a problem. ...
By Parasym Ltd.
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Nanostics Receives CE Mark for its ClarityDX Prostate Test to Detect Clinically Significant Prostate Cancer
Nanostics’ biomarker and machine learning-powered test, ClarityDX Prostate®, received a CE-IVD Mark. A CE-IVD Mark is required for all in vitro diagnostic (IVD) devices to be placed in the European Economic Area, Iceland, Norway, and Liechtenstein and allows Nanostics to market and sell ClarityDX Prostate® in these countries. The ClarityDX Prostate® test provides patients ...
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Nanostics Announces Study Data Supporting ClarityDX Prostate as a Reflex Test to Predict Clinically Significant Prostate Cancer
Real-world data shows that at a 94% sensitivity level for prostate cancer ClarityDX Prostate® is 147% more specific than the PSA test for predicting clinically significant prostate cancer. Using ClarityDX Prostate® as a reflex test vs. PSA test alone could have resulted in 37% fewer unnecessary biopsies. The clinical study recruited men from two sites in Alberta, Canada, and one site ...
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Nanostics Announces the Launch of its Bladder Cancer Clinical Study Identifying Disease Predictors for Early Detection of Bladder Cancer
Clinical study launched in June 2022 with patient recruitment in Alberta with plans to expand to further sites across North America. The aim of the study is to validate a novel and minimally invasive liquid biopsy test for bladder cancer diagnosis using Nanostics’ ClarityDX® diagnostic platform. The study is supported in part by the Alberta Innovates AICE-Concepts Program with a ...
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Top Advances in Echocardiography Transforming Cardiac Imaging on World Heart Day
In honor of World Heart Day on September 29, we're diving into the world of cardiovascular diagnostics. Echocardiography, one of the most widely used screening and diagnostic modalities in healthcare, has seen a resurgence thanks to advances and groundbreaking innovations within the last few years. Join us as we explore the top trends shaping these diagnostic methods. 1. ...
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Cost-Effectiveness of Percutaneous Deep Vein Arterialization for Patients with No-Option Chronic Limb-Threatening Ischemia: an Exploratory Analysis Based on the PROMISE I Study
Abstract Background. As the most advanced stage of peripheral arterial disease (PAD), chronic limb-threatening ischemia (CLTI) is associated with a high risk of lower-limb loss and mortality. Percutaneous deep vein arterialization (pDVA) is a promising new treatment alternative for CLTI patients who cannot be treated with conventional revascularization techniques. Our study objective was to ...
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