clinically available Articles
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Phase I STTR award
Gene.iobio is a popular variant analysis tool developed at the University of Utah in the laboratory of Professor Gabor Marth. With an average of 15,000 weekly page views, gene.iobio is used by academic variant analysts, clinical researchers, and is available to customers of a direct to consumer genomics company. In order to continue delivering a high-quality experience to all users, we have ...
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The Potency Determination of 15 Cannabinoids using the Hemp Analyzer
According to a 2020 Grand View Research report, the industrial hemp market is expected to exceed 15 billion USD by 2027. This accounts for all segments of the market, including application of the product in pharmaceuticals, medicinal and therapeutic products, skin care products, and fiber/textiles. This growth, and the confidence in hemp products, will require applicable testing to ensure product ...
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OneThree`s Workflow for Predicting Drug Toxicity - Case study
Background OneThree Biotech was born out of the largest precision medicine institute in America with the purpose of decreasing the failure rate of bringing therapeutics to market using biology driven artificial intelligence. Our technology was builtin a lab setting; allowing us to engineer our methodologies around real-world results. While working with major biotech and pharma partners; ...
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Diabetomics Lumella - New Point-of-Care Blood Test Kit for Early Detection of Preeclampsia
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. We recently reported that many RA patients have anti-citrullinated albumin (ACA) ...
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The race to a vaccine - unintended consequences?
A gold rush is on to find a vaccine for COVID-19. According to the World Health Association (WHO) in early May, there are more than 100 projects around the world centered on the development of a vaccine for the coronavirus. Eight candidate vaccines are already being tested in people in clinical trials. Once an effective vaccine (or vaccines) has been identified, it will need to be produced ...
By Vistex Inc
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New structural target against COVID-19
A new structural target for drug development against COVID-19 has been unveiled today by Sibylla Biotech in collaboration with the Italian National Institute of Nuclear Physics (INFN), the University of Trento and University of Perugia.The breakthrough drug discovery strategy pioneered by Sibylla in this study would not only promise to reduce the risk of drug resistance and harmful side effects, ...
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SpinTech MRI Earns FDA 510(k) Clearance for Rapid, Quantitative Brain-Imaging Technology
The US Food and Drug Administration (FDA) has given 510(k) clearance to SpinTech MRI’s latest magnetic resonance imaging software device, STAGE (STrategically Acquired Gradient Echo), a post-processing software platform that enables comprehensive, quantitative brain imaging with enhanced visualization in significantly less time than conventional approaches. STAGE allows MRI ...
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Diagnosing heart failure with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine, overtaking heart failure with reduced ejection fraction (HFrEF) and becoming the most common form of heart failure, with a prevalence that is increasing by 1% annually.[1] Despite this, there remains no gold standard in diagnosing HFpEF. Diagnosing ...
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Bardy Diagnostics Carnation Ambulatory Monitor Patch decreases both time to diagnosis and readmissions in Emergency Department patients with possible arrhythmia concerns in Clinical Study from Overlake Medical Center
BELLEVUE, WA — July 29, 2021– A recent clinical study from Overlake Medical Center utilizing the Bardy Diagnostics Carnation Ambulatory Monitor (CAM) patch was presented at the 2021 Heart Rhythm Society (HRS) Conference. The abstract, “Accelerating Proper Evaluation of Emergency Department Patients for Arrhythmia Concerns with Discharge Use of ECG Patch Monitors,” authored ...
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Clinical implementation of the Humacyte human acellular vessel: Implications for military and civilian trauma care
ABSTRACT: The incidence of wartime vascular injury has increased and is a leading cause of mortality and morbidity. While ligation remains an option, current resuscitation and damage control techniques have resulted in vascular repair being pursued in more than half of wartime injuries. Options for vascular reconstruction are currently limited to autologous vein or synthetic conduits, choices ...
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Monoaromatic Heterocyclic Chemistry: Applications and Synthesis
Summary Heterocyclic compounds with aromatic characteristics are called aromatic heterocyclic compounds, which can be classified into monoaromatic heterocycles and fused heterocycles. The common monoaromatic heterocycles are five-membered Furan, Pyrrole, Thiophene, Pyrazole, Imidazole, Oxazole, etc., and six-membered Pyridine, Pyranone, Pyridazine, Pyrimidine, Triazine, etc. Aromatic ...
By BOC Sciences
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Understanding Pediatric Cardiomyopathy: Causes, Symptoms and Treatment Options
Up to 5,000 American infants and children are diagnosed with pediatric cardiomyopathy each year. Learn more about this rare but potentially serious condition. Cardiomyopathy, which is a general term for diseases of the heart muscle, is relatively rare in children, affecting only about 12 out of every 1 million Americans under the age of 18. Among the approximately 1,000 to 5,000 new cases ...
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Three generations of ADC Nearly a decade of development-PIII
Novel cytotoxic drugs New cytotoxic drugs have been developed to target cancer cells with low antigen expression or resistance to auristatins or maytansinoids. For this purpose, PBD dimers have been developed, which have a molecular structure containing two alkylated imine functional groups capable of forming covalent bonds with DNA.PBD dimers are about 50-100 times more potent than conventional ...
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Idience: developing selective and potent PARP inhibitor IDX-1197 for solid tumors
The first wave of PARP inhibitors has improved outcomes in people with a variety of solid tumors. However, Idience has identified opportunities to improve the efficacy of existing drugs and overcome resistance. The company plans to target homologous recombination repair-proficient patients with a clinical-phase PARP inhibitor that is now available for licensing. Ildong Holdings, a major ...
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Cost-Effectiveness of Percutaneous Deep Vein Arterialization for Patients with No-Option Chronic Limb-Threatening Ischemia: an Exploratory Analysis Based on the PROMISE I Study
Abstract Background. As the most advanced stage of peripheral arterial disease (PAD), chronic limb-threatening ischemia (CLTI) is associated with a high risk of lower-limb loss and mortality. Percutaneous deep vein arterialization (pDVA) is a promising new treatment alternative for CLTI patients who cannot be treated with conventional revascularization techniques. Our study objective was to ...
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12 Protocols for Balance Assessment with force/pressure plate
Balance is achieved and maintained by a complex set of sensorimotor control systems. (check What is Balance?) When any of these systems is injured or deficient, balance can markedly be affected. Therefore, it is important to have tools that can help health professionals identify if there is a balance problem and the specific nature and/or the cause of the problem. Several conditions like stroke, ...
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Costs Attributable to Arteriovenous Fistula and Arteriovenous Graft Placements in Hemodialysis Patients with Medicare coverage
Keywords Vascular access · Hemodialysis · Healthcare costs · Health economics · Arteriovenous fistula · Arteriovenous graft Abstract Introduction: Hemodialysis (HD) in end-stage renal disease (ESRD) patients requires vascular access (VA) through an arteriovenous fistula (AVF), a prosthetic arteriovenous graft (AVG), or a central venous catheter. While AVF or ...
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The 7-Steps to Recuperation from Stroke Arm Paralysis
About two-thirds of those that experience arm paralysis after stroke are unable to fully use their affected limb six months after stroke (1-3). Not having a fully functional arm and hand after a stroke is not only frustrating but also devastating to many individuals. Day-to-day operations and activities of daily living become more difficult, take longer to complete, and may require assistance ...
By Neurolutions
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