clinically effective Articles
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Pre-Clinical Effectiveness - Case Study
VersaWrap as a Protective Interface Background: Fibrous scar tissue between tendon and the surrounding tissue is a common complication following flexor tendon repair. Several factors contribute to scar tissue formation, including damage to the tendon sheath, suture placement, and tendon immobilization. Scar tissue formation results in increased work of flexion (WOF) and contracture formation, ...
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Forms of technology and effectiveness of infertility clinics
The form of technology adopted by a clinic (long-linked vs. intensive technology) was examined here as a contingency factor in assessing the effectiveness of two infertility clinics. Each clinic used a different medical technique for treatment, reflecting a different form of technology. The relationships of technology forms with clinic effectiveness were explored using a case-study approach. It ...
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Impact of low anterior resection syndrome (LARS) on quality of life
Low anterior resection syndrome (LARS) has a substantial negative impact on quality of life and almost 70% of patients experienced major LARS 1-11 years after rectal surgery. Rectal cancer patients experience symptoms of low anterior resection syndrome (LARS) several years after their rectal surgery with a substantial impact on quality of life (QoL) as shown in this observational cohort study. ...
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Preliminary evidence of efficacy from an open label trial of a therapeutic AIDS vaccine derived from the blood of HIV-positive donors
Two earlier reported studies indicated the beneficial clinical effects of THIVAC, a therapeutic HIV vaccine derived from the blood of HIV-positive donors. However, in those studies no stringent statistical analysis to support the beneficial clinical outcome was attempted. This report retrospectively analyses the effect of the therapy on the CD4 counts in 272 treated individuals who had at least ...
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Marsi-Bionics presents the clinical successes of its exoskeletons to internal medicine doctors
The Atlas 2030, the world's only exoskeleton for children, is capable of achieving much more effective therapy in the treatment of Spinal Muscular Atrophy The Mak Active Knee, the exoskeleton that works like a robotic knee, is achieving previously impossible rehabilitations due to speed and absence of pain Elena Garcia Armada, founder of Marsi-Bionics and scientific researcher at the CSIC, ...
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Rho kinase inhibition in Amyotrophic Lateral Sclerosis - Case Study
REAL is a phase 2a open-label study to assess preliminary safety, tolerability, and effect on clinical outcomes as well as neurodegeneration biomarkers of BRAVYL in patients with ALS. The study will enroll approximately 20 patients, all of whom will be treated with BRAVYL for 24 weeks. ...
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The Effects of Excipients on Pharmaceutical Preparation
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
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The Effects of Excipients on Pharmaceutical Preparations in Drug Design
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
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Accurate CO Tracking During High-Risk Surgery - Case Study
A head-to-head comparison shows that the Retia Argos Monitor accurately tracks changes in CO as the vena cava is clamped and unclamped during liver surgery, while the leading competitor monitor fails. As shown, the Argos Monitor tracks with the reference standard, while the competitor monitor shows increasing CO when the vena cava is clamped and CO is actually decreasing (205 – 210 ...
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Clinical significance of low-dose radiation therapy: radiation hormesis
This study was designed to investigate the clinical significance of low-dose radiation therapy, radiation hormesis, and accuracy of therapeutic regimen. Radiation hormesis was performed in six patients (four patients with malignant diseases and two patients with benign diseases) in the experimental room where they could be exposed to a low level of direct gamma ray and inhale radon gas ...
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Mechanism of action and therapeutic efficacy of the biotechnology-derived immunostimulating extract OM-85 in respiratory tract infections
The burden of Respiratory Tract Infections (RTIs) in children and adults is very high, especially in developing countries. At least 1.9 million children throughout the world died from acute RTIs in 2000, 70% of them in Africa and Southeast Asia. As causative therapies of these frequently recurring infections have substantial limits, preventive measures deserve priority. Among these, non-specific ...
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Idience: developing selective and potent PARP inhibitor IDX-1197 for solid tumors
The first wave of PARP inhibitors has improved outcomes in people with a variety of solid tumors. However, Idience has identified opportunities to improve the efficacy of existing drugs and overcome resistance. The company plans to target homologous recombination repair-proficient patients with a clinical-phase PARP inhibitor that is now available for licensing. Ildong Holdings, a major ...
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A Quick Guide to Proteolytic Enzymes
Protease formulations are without a doubt one of the most fully functional dietary supplements in terms of providing significant health benefits. Clinical studies have documented numerous effective benefits and support for people facing a variety of health challenges, including: a) Asthma b) Atherosclerosis c) Autoimmune disease d) Bronchitis e) Cancer f) ...
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Cost-Effectiveness of Percutaneous Deep Vein Arterialization for Patients with No-Option Chronic Limb-Threatening Ischemia: an Exploratory Analysis Based on the PROMISE I Study
Abstract Background. As the most advanced stage of peripheral arterial disease (PAD), chronic limb-threatening ischemia (CLTI) is associated with a high risk of lower-limb loss and mortality. Percutaneous deep vein arterialization (pDVA) is a promising new treatment alternative for CLTI patients who cannot be treated with conventional revascularization techniques. Our study objective was to ...
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Can We Predict Treatment Success in tVNS?
Predicting Treatment Success Transcutaneous vagus nerve stimulation (tVNS) has recently emerged as a promising treatment for depression and an effective mood enhancer, showing benefits over similar treatments including traditional vagus nerve stimulation (VNS) which is invasive and costly. tVNS targets the auricular branch of the vagus nerve and works by applying a small electrical stimulation ...
By Parasym Ltd.
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A new skin care peptide discovered
Nuritas announces the discovery of a new ingredient: PeptiYouth, the first nature-identical peptide discovered by AI that helps restore the extracellular matrix and addresses five key signs of aging. PeptiYouth succeeds in creating synergy with retinol and vitamin C, demonstrating that it is possible to improve skin care formulas. This intelligent plant-derived ingredient has been hidden in ...
By Nuritas Ltd.
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Researchers Prepared New Tools for the Production of Exosome Drug Carriers
Recently, Yang Hui, a researcher at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, developed a nanofluidic chip technology to achieve high-throughput preparation of exosome drug carriers and experimentally verify the anti-tumor effect of novel exosome drug carriers. Exosomes are nanoscale particles that can be secreted into the extracellular space or body fluids by ...
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Getting CPOE Adoption Right
Chris Snyder, a speaker at the marcus evans National Healthcare CMO/CMIO Summit 2013, on effective CPOE adoption. Interview with: Chris Snyder, Chief Medical Information Officer, Peninsula Regional Medical Center The adoption of Computerized Physician Order Entry (CPOE) technologies has been slow in the US, although 2014 is the proposed start date for Stage 2 of the Meaningful Use Requirements. ...
By Marcus Evans
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3D Bioprinting Of Prevascularised Implants For The Repair Of Critically-Sized Bone Defects
By combining different cell populations in a fibrin bioink, researchers from Trinity College Dublin, Royal College of Surgeons in Ireland and University of Illinois Chicago were able to sprout an in vitro microvessel network that was then exploited to prevascularise a 3D printed scaffold implanted in a critical size femoral defect using REGENHU bioprinter. This dual approach was observed to ...
By Regenhu
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SmartTab Completes Gastric Environment Validation Study for InjectTab™ Platform
What if you were able to simply take a pill to receive the medication you’re used to receiving through a shot, like insulin? As a leading innovator and disruptive drug delivery company, SmartTab is driving the future of drug delivery to places people would have never expected it to go and injections with a conventional syringe and needle will soon be a thing of the past. SmartTab's ...
By SmartTab
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