clinically evaluated Articles
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hVIVO used Nuvonis’ GMP Vero cells to produce Novel SARS-CoV-2 virus for a human challenge model
One of the main benefits of using Nuvonis’ fully tested GMP Vero cells is the unparalleled speed towards clinical trials. A case example from one of our customers, hVIVO: First contact with Nuvonis in July 2020, due diligence, contracting, provision of GMP Vero cells and protocols, as well as full documentation Production of GMP material in November 2020 ...
By Nuvonis
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Aramis Biosciences Announces First Patient Dosed in Phase 2 Clinical Trial Evaluating A197 for the Treatment of Dry Eye Disease
Aramis Biosciences announced that the first patient has been dosed in its phase 2 proof of concept clinical trial evaluating A197, a novel, first-in-class, topical immunomodulatory agent for the treatment of dry eye disease. “This is an important milestone for Aramis Biosciences and a hopeful moment for dry eye patients given the suboptimal efficacy and tolerability limitations commonly ...
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4 factors that make a nasal aspirator safe
Do you remember the moment when you found that you have to clear your baby’s nose? You probably thought it was a joke and you didn’t want to believe it. “A nasal aspirator? What else will they come up with… Do I really need it? Is that even safe?!” Most parents share your doubts at first. However, these uncertainties disappear once you find out how much relief a ...
By Nosiboo
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Combatting the Opioid Crisis with Cell Therapies for Chronic Back Pain
It’s no secret that opioid addiction is at an all-time high and represents a major public health threat. The CDC estimates that opioid addiction resulted in a record 72,000 drug overdose deaths in 2017 alone. What strikes me as one of the most tragic parts of this narrative is that so many of these deaths were people who became addicted to opioids after simply seeking relief ...
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Cell-Penetrating Peptides: Features, Mechanisms, Applications
Cell-penetrating peptides (CPPs) refer to water-soluble, partly hydrophobic, and/or polybasic short peptides that are fewer than 30 amino acids in size. Different types of CPPs like chimeric peptides and hydrophobic peptides have different lengths, charges, solubility, and hydrophobicity. At current, cell-penetrating peptides are often classified in line with their characteristics, including ...
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Application of Flow Cytometry in the Pharmaceutical Industry
Flow cytometry (FC) is an important tool for analyzing complex pathways and responses of single cells, which can track cell phenotypes and functions in multiple dimensions. It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or ...
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HIT Weekly Series Episode 6 - Conclusions
Today, HIT remains a critical clinical context in many hospital settings, when heparin, mainly unfractionated, is used in cardiology, intensive care units, or ECC, including CPB and increasingly ECMO. This is a paradoxal disease, as this anticoagulant drug can provoke thrombocytopenia associated with thrombosis in affected patients. Detecting the risk of HIT is mandatory, as it requires an ...
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The Development Process of DUBTAC
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered “undruggable”, and several projects have entered clinical evaluation worldwide. Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer. ...
By BOC Sciences
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High Throughput SHERLOCK CRISPR SARS-CoV-2 Test
Abstract: The ability to control the spread of COVID-19 has been hampered by a lack of rapid, scalable, and easily deployable diagnostic solutions. Efforts to increase testing capacity have been adversely impacted by supply chain challenges due to dependencies on a limited set of reagents, consumables, and instrumentation. Here, we present a diagnostic method based on CRISPR (clustered regularly ...
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FluGen Awarded US Department of Defense Funding to Conduct Clinical Study Evaluating Investigational M2SR Flu Vaccine and Current Standard-of-Care High Dose Vaccine
Study is the Company’s first trial evaluating ability of M2SR and the current licensed standard of care to protect against drifted virus strains, and its second study in older adults, a population most vulnerable to mortality from flu – Safety and immunogenicity study expected to begin in Q2 2022 – MADISON, Wis., July 1, 2021 /PRNewswire/ — FluGen, Inc., a clinical-stage ...
By FluGen, Inc.
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Homocysteine, vitamin B12 and folic acid plasma levels in relation to cognitive functions in an Egyptian elderly group
Several studies suggested that elevated plasma total homocysteine (tHcy) concentrations are associated with cognitive impairment and dementia. High plasma homocysteine concentrations can be largely attributed to inadequate status of folic acid and vitamin B12. On the other hand, data from several studies indicate that plasma homocysteine increases with age, independent of vitamin status. We ...
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No-touch Forehead Temperature Measurement in Two Clinical Settings
Background. Healthcare personnel prefer devices that maximize efficiency while minimizing cross-contamination as well as cost. The Caregiver® (Thermomedics, Inc., Miami. FL), a new infrared non-contact forehead thermometer has been developed for clinical professional use. Our objective was to evaluate the clinical accuracy and repeatability of the Caregiver as compared to measurements ...
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Rational Vaccines Announces a Clinical Trial to Determine Baseline Characteristics of Patients Diagnosed With Recurrent Symptomatic Herpes Simplex Type 2 (HSV-2) Virus
Study to be conducted at two leading research institutions in the U.K. Results will inform protocol design of Phase 1/2 clinical trial of Company's lead HSV-2 therapeutic vaccine candidate WOBURN, Mass. and OXFORD, England, Aug. 15, 2022 /PRNewswire/ -- Rational Vaccines, a company focused on revolutionizing the treatment and prevention of herpes to eradicate the disease, today announced the ...
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Bispecific Antibodies and Bispecific Antibody ADCs
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches have emerged. Bispecific antibody conjugates (BsAb ADCs) are one of the emerging new technologies. The high specificity of bispecific antibodies enables more precise targeting of tumor cells. On the other ...
By BOC Sciences
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Dyve Biosciences enrolls first patient in gout trial
Dyve Biosciences announced today that it enrolled its first patient in the Phase 2 clinical study of its DYV-700 topically administered therapeutic for acute gout treatment. Thousand Oaks, Calif.–based Dyve won FDA clearance to begin the Targets Phase 2 trial in December 2019. The double-blind, placebo-controlled, randomized clinical trial is set to evaluate the efficacy of DYV-700 in ...
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Why Healthcare Needs to Think Provider Quality Management and Not Just Peer Review
When an adverse event occurs, the immediate priority is to deal with the situation at hand. Move beyond those immediate and reactive issues and the improvement-minded naturally begin to think about causal and contributory factors and their related corrective actions. These typically fall into two key areas: human and system factors. Human Factors Driven by regulatory and accreditation ...
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Validation of a two-gene mRNA urine test for detection of high-grade prostate cancer in German men.
Organizations Martini-Klinik Prostate Cancer Center and Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, MDxHealth, B.V., Nijmegen, Netherlands, MDxHealth, Inc., Irvine, CA, Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium, Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany Abstract ...
By MDxHealth
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Antibody-Drug Conjugates For The Treatment of Prostate Cancer
Currently, ADC has played a significant role in the treatment of some malignant tumors, such as trastuzumab in the treatment of breast cancer, but its application in the treatment of prostate cancer (PCa) progress slowly. In recent years, ADC has made rapid progress in the treatment of metastatic castration-resistant prostate cancer (mCRPC). STEAP1, TROP2, PSMA, CD46, and B7-H3 are currently ...
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Polymeric Membrane Dressings for Topical Wound Management of Patients With Infected Wounds in a Challenging Environment: A Protocol With 3 Case Examples
Dr. Linda Benskin, a PhD wound specialist nurse with a pediatrics background, volunteered for five years in rural West Africa teaching village health workers, treating medical patients, and managing wounds. During this time, she discovered PolyMem® wound dressings among boxes of donated bandages. In that extremely hot climate, other modern dressings made infections worse or slowed healing, ...
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Challenging brain diseases continue to demand new, efficient treatment methods
During this spring, the COVID-19 pandemic has dramatically changed every aspect of life. The business environment has changed not to mention the healthcare sector where the very foundations have been tested around the world. The news have been filled with corona topics and at times the pandemic has seemed to hide other alarming issues: for example, it has been reported in the US that ...
By Nexstim Plc
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