clinically informative Articles
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Short Bowel or Short Fuse; Finding the patience to survive with a short gut
A parents perspective If you have not had the chance to read A Parent’s Perspective: Our Son’s Short Bowel Syndrome Diagnosis, I encourage you to do so. While the goal is to give as much insight into Short Bowel Syndrome as possible, we want to steer clear of the boring clinical information online. From one Short Bowel Parent to another, trust me, you’ll have no better teacher ...
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Exploring Knowledge Graphs for COVID-19 Drug Discovery
Today, there are only a few therapies approved to treat COVID-19, but while novel therapies can take decades and billions of dollars to develop, are there opportunities to repurpose existing drugs for new therapies? Our latest whitepaper showcases how CAS Knowledge Graphs reveal new connections and insights that identify drugs to potentially repurpose. Drug repurposing is critical for faster ...
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A study of e-discussion within a domain of uncertainty: the case of Tourette’s Syndrome
The growing popularity of the internet has made it easier and faster to find health information on rare and poorly understood disease topics. Much of this information is valuable, though the internet also allows the rapid and widespread distribution of false and misleading information, especially through peer-based networks. Providers frequently advise that it is important for health consumers to ...
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Application of Enzyme Detection in Clinical Diagnosis
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Israeli hospital pilots rapid diagnostics of blood cancer with Sight Diagnostics
Israeli-founded firm Sight Diagnostics, the company that uses AI and cutting-edge hardware to deliver rapid, complete blood count results, has signed a new research agreement with Jerusalem’s Shaare Zedek Medical Center to identify the possibility of blood cancer using a combination of images and data collected from Sight’s OLO device and patient clinical information provided by the ...
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Amplicon Sequencing for Microbiome Research: Introduction, Advantages, and Applications
The identification of microbial groups is an important step in understanding the interrelationship of microorganisms in a community. It is done to determine all present microbial taxa and their relative abundance, and as well their phylogenetic relationships. One of the methods used to establish phylogenetic relationships is by sequencing common genes. One of the easiest genes to be sequenced are ...
By CD Genomics
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Managing clinical knowledge among hospital nurses
Knowledge Management (KM) tools and processes, while established in many industries, are relatively new to healthcare. Healthcare organisations resemble virtual organisations that build flexible and dynamic care networks of multiple medical providers and professionals to address a patient's needs. This research studies the major factors impacting clinical KM strategy and processes in the floor ...
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TAILOR-PCI Proves Genotype-guided Antiplatelet Therapy Reduces MACE
TAILOR-PCI was a 7-year 5,300-patient clinical trial of precision medicine for cardiac stent patients, funded by Mayo Clinic and the National Institutes of Health (NIH). Genomadix’s FDA-cleared rapid RX CYP2C19 genotyping test was used to personalize antiplatelet therapy with clopidogrel or ticagrelor. The results were published on August 25, 2020 in the Journal of the American Medical ...
By Genomadix
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Genomadix’s European Scientific Advisory Board Comments on TAILOR-PCI Results
Genomadix’s European Scientific Advisory Board Comments on TAILOR-PCI Results *The largest genetics-based clinical trial in cardiology history supported by Genomadix’s Precision Medicine technology * The results of the TAILOR-PCI trial (Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention) were recently ...
By Genomadix
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The Toxicity Atlas - One year later
It’s been about a year since I started my PhD project named The Toxicity Atlas. In this four-year project, I’m collaborating with researchers from Amsterdam UMC and my colleagues at Medstone to find better treatment options for patients with brain cancer. Let me tell you more about my results so far. Information databases Developing new drugs costs a lot of money and a lot of ...
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Dermal absorption of chlorpyrifos in human volunteers
Objective: The methods and results are described of a study on the dermal absorption of chlorpyrifos (CPF) in humans established via urinary excretion of the metabolite 3,5,6-trichloro-2-pyridinol (TCP). Methods: Two dermal, single, doses of CPF were applied in two study groups (A and B) each comprising three apparently healthy male volunteers who gave their written informed consent. The clinical ...
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Rational Vaccines Announces a Clinical Trial to Determine Baseline Characteristics of Patients Diagnosed With Recurrent Symptomatic Herpes Simplex Type 2 (HSV-2) Virus
Study to be conducted at two leading research institutions in the U.K. Results will inform protocol design of Phase 1/2 clinical trial of Company's lead HSV-2 therapeutic vaccine candidate WOBURN, Mass. and OXFORD, England, Aug. 15, 2022 /PRNewswire/ -- Rational Vaccines, a company focused on revolutionizing the treatment and prevention of herpes to eradicate the disease, today announced the ...
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Bridging Clinical Research to Real-World Patient Care Through Predictive Analytics
The ability to predict how a clinical trial participant will adhere to their treatment, and even respond to that treatment, has great promise to advance patient-centric clinical research. But, as we look to understand the impact a drug has on patients’ everyday health outside of a research environment, what happens to these unique, predictive findings around dosing and outcomes once a drug ...
By AiCure
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Top Advances in Echocardiography Transforming Cardiac Imaging on World Heart Day
In honor of World Heart Day on September 29, we're diving into the world of cardiovascular diagnostics. Echocardiography, one of the most widely used screening and diagnostic modalities in healthcare, has seen a resurgence thanks to advances and groundbreaking innovations within the last few years. Join us as we explore the top trends shaping these diagnostic methods. 1. ...
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Proteins That Provide Key Information to Identify Patients with Poor Prognosis Found
In recent years, immune-based cancer treatment methods have given doctors and patients a lot of hope. Drugs called immune checkpoint inhibitors have provided life-saving benefits to more and more people suffering from melanoma, lung cancer, bladder cancer, and many other types of cancer. Although these drugs are exciting, a frustrating sticking point is that doctors cannot predict who will ...
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RARE ANSWERS™: A System to Improve Patient Outcomes - Case study
At Alexion, our mission is to transform the lives of people affected by rare diseases and devastating conditions. In addition to developing and delivering life-changing medicines, this mission drives us to seek opportunities to advance innovative solutions to system-wide challenges faced by rare disease patients, such as the “diagnostic odyssey.” What is the Diagnostic Odyssey? ...
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Introducing Navigating Cancer’s Medical Advisory Board Ahead of ASCO Presentations Illustrating Equitable Cancer Care Innovation
Navigating Cancer is filling an important role in the healthcare community during a time that has placed tremendous pressure on healthcare providers to better support a growing and diverse patient population, outside-of-the-clinic. Digital health tools and remote symptom monitoring enable more efficient care delivery and improve patient outcomes – while providing actionable insights based ...
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Applications of Single-Cell RNA Sequencing in Drug Discovery and Development
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. This knowledge enhances our understanding of ...
By CD Genomics
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Preliminary Examination of the Ability of a New Wearable Device to Capture Functional Hand Activity After Stroke
Background and Purpose— A reliable measure of movement repetitions is required to assist in determining the optimal dose for maximizing upper limb recovery after stroke. This study investigated the ability of a new wearable device to capture reach-to-grasp repetitions in individuals with stroke. Methods— Eight individuals with stroke wore an instrumented wrist bracelet while ...
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