clinically used Articles
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An independent assessment of AI for prostate cancer detection - Case Study
Yale Medicine, an academic medical center with a high volume of prostate biopsies, conducted a study to determine Paige Prostate’s utility as a prescreening tool for clinical use. A total of 1,876 prostate core biopsy slides were analyzed by Paige Prostate, and only those cores categorized by the AI as “suspicious” or as out of distribution were manually reviewed by Yale ...
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Forms of technology and effectiveness of infertility clinics
The form of technology adopted by a clinic (long-linked vs. intensive technology) was examined here as a contingency factor in assessing the effectiveness of two infertility clinics. Each clinic used a different medical technique for treatment, reflecting a different form of technology. The relationships of technology forms with clinic effectiveness were explored using a case-study approach. It ...
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Chest CT Segmentation - Case study
The challenge An industry-leading medical device company required the capability to automatically generate an accurate 3D model of complex patient-specific anatomies The anatomical model was needed for planning challenging surgical navigation procedures The pre-existing solution was slow and not robust, requiring extensive and time-consuming manual editing by the interventionist Our ...
By RSIP Vision
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Preliminary studies of EDDA-tricine-HYNIC-Tyr³-octreotide labelled with technetium-99m: radiopharmaceutical development for the diagnosis of neuroendocrine tumours
The use of labelled molecules with high specificity for an organ or receptor in scintigraphy generates good local images and minimises the exposure of other organs. Octreotide was the first somatostatin synthetic analogue introduced in clinical use in the localisation of tumours with superexpression of somatostatin receptor (sstr). This work studied the labelling of HYNIC-Tyr3-octreotide with ...
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Ayurvedic potentials for cellular protection, regeneration and immunomodulation with special reference to resistance against low radiation
The exposure to acute low Linear Energy Transfer (LET) at more than 10 rem or 0.1 Sv due to background radiation, occupation exposure or free radicals appears to be responsible for biological changes that have a health impact on cells, including DNA damage and contribute to the ageing process and to the manifestation of diseases, including cancer. Individuals and subpopulations (cultural groups ...
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Direct Detection of Unamplified Hepatitis C Virus RNA Using Unmodified Gold Nanoparticles
Abstract Background:Gold nanoparticles (AuNPs) exhibit a unique phenomenon known as Surface Plasmon Resonance,which is responsible for their intense red color. This color changes to blue upon aggregation of AuNPs. Objective:Thiswork aims to develop a rapid, simple and cheap assay for direct detection of unamplified HCV RNA extracted from clinical samples using unmodified AuNPs. Methods:Serum ...
By D-Kimia, LLC
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The impact of variability in the risk of disease exemplified by diagnosing diabetes mellitus based on ADA and WHO criteria as gold standard
The diagnosis of clinically mute diabetes mellitus (DM) is based on a nominal concentration of fasting peripheral venous plasma glucose (f-vPG) at ≥7.0mmol/l, to be exceeded by first and confirmatory measurement. Aim: to identify error sources in the clinical use of biochemical data, to use the diagnostic concept for clinically mute DM. Materials and methods: error contributors were established. ...
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Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including Parkinson’s disease (PD). Despite widespread clinical use, its therapeutic mechanisms are unknown. Here, we developed a mouse model of subthalamic nucleus (STN) DBS for PD, to permit investigation using cell type–specific tools available in mice. We found that electrical STN DBS relieved ...
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Clinical validation of the Caregiver non-contact thermometer model PRO-TF300 in febrile and afebrile patients age 0 to < 18
Background: The CAREGIVER Thermometer Model PRO-TF300 (Thermomedics Inc., Delray Beach, FL) is a non-contact clinical professional thermometer used to read human body temperature in children and adults through the determination of infrared energy from the middle of the forehead. The purpose of this paper is to describe the methods and findings of the CAREGIVER’S validation for clinical use ...
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SpinTech MRI Earns FDA 510(k) Clearance for Rapid, Quantitative Brain-Imaging Technology
The US Food and Drug Administration (FDA) has given 510(k) clearance to SpinTech MRI’s latest magnetic resonance imaging software device, STAGE (STrategically Acquired Gradient Echo), a post-processing software platform that enables comprehensive, quantitative brain imaging with enhanced visualization in significantly less time than conventional approaches. STAGE allows MRI ...
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Many Faces of Sepsis (1): Cancer Therapy and Management Febrile Neutropenia - Case Study
The purpose of this case study is to highlight ways in which medical algorithms can be integrated into the clinical decision making process. This case study is the first of a series focused on sepsis, a common but complex clinical problem. Use of algorithms can help healthcare providers diagnose sepsis early. Throughout our discussion, appropriate algorithms are suggested to help clinicians ...
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Clinical validation of the Caregiver non-contact thermometer model PRO-TF200/ PRO-TF300 in febrile and afebrile patients of all ages
Background. The CAREGIVER® Model PRO-TF200 and PRO-TF300 (Thermomedics, Miami, FL) are non-contact clinical professional thermometers used to read human body temperature in children and adults through the determination of infrared energy from the middle of the forehead. Both models function identically, thus they will be referred to hereafter as "CAREGIVER". The purpose of this paper is to ...
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Performance Evaluation of the Circadia Contactless Respiratory Monitor and Circadia Sleep Analysis Algorithm
Abstract—The current study aims to evaluate the performance of the Circadia Sleep Analysis Algorithm, which - in combination with the non-contact and minimally invasive Circadia bedside monitor - allows for long-term sleep assessment and continuous evaluation of sleep therapy outcomes. The Circadia Contactless Respiratory Monitor was initially used to record 17 nights of sleep data from 9 ...
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Robotic Surgery: Who will be the Next Top Dog?
The competitive stakes in robotic surgery have never been higher as medical device companies try to disrupt the market that Intuitive Surgical pioneered more than two decades ago. Robotic surgery pioneer Intuitive Surgical celebrated a big milestone this week: The number of robotic-assisted procedures performed worldwide using the da Vinci surgical system has just surpassed 10 million. ...
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Value-Based Robotics, Pt.4: Micromate™ - Bringing Usability To The Operating Room
Our Value-Based Robotics series advances towards the actual clinical use of robotics and issues concerning practicality and surgeon onboarding and training. It is generally accepted that robotic surgical systems enable minimally invasive surgery and improve outcomes, including shorter recovery times, less scarring, and reduced healthcare costs. This being said, the jury is still out on whether ...
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7 Medical Calculators for Celiac Disease Diagnosis - Case Study
This case study is presented to highlight how medical calculators can be useful clinical decision making tools for celiac disease diagnosis. Throughout the discussion, links to medical calculators that healthcare providers can use are provided. Incorporating these resources into a clinician’s workflow can lead to better outcomes through more accurate diagnoses and better management for this ...
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7 Things You Should Know About Artificial Hearts
Artificial hearts may sound like science fiction, but they’ve actually been in clinical use to help end-stage heart failure patients for more than 35 years — here’s what you should know. As the number of patients suffering from heart disease has increased over the years, so too has the need for heart transplants. Unfortunately, the global supply of donor hearts remains limited, ...
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Comparison of Quantity of Coronary Atherosclerotic Plaques Detected by Computed Tomography Versus Angiography
Abstract Numerous clinical studies using coronary computed tomography angiography (CTA) and conventional invasive coronary angiography (ICA) confirmed the strong relation between atherosclerotic disease burden and risk of adverse events. Few studies have compared coronary CTA and ICA regarding semiquantitative plaque burden measurements, reproducibility, and cardiovascular risk assessment. ...
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Combatting the Opioid Crisis with Cell Therapies for Chronic Back Pain
It’s no secret that opioid addiction is at an all-time high and represents a major public health threat. The CDC estimates that opioid addiction resulted in a record 72,000 drug overdose deaths in 2017 alone. What strikes me as one of the most tragic parts of this narrative is that so many of these deaths were people who became addicted to opioids after simply seeking relief ...
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Dynamic process modelling of patients` no-show rates and overbooking strategies in healthcare clinics
Abstract: Clinic appointment cancellation and 'no-shows' by patients can disturb day-to-day scheduling and lead to inefficient resource allocation and lost revenue. This paper presents an approach for dynamic process modelling and analysis of patients' no-show rates in conjunction with the overbooking strategy. To this end, a dynamic discrete event simulation model of a clinic operation is ...
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