colitis Articles
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Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment ...
By KoBioLabs
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Characterization of an escherichia coli o157:h7 o-antigen deletion mutant and effect of the deletion on bacterial persistence in the mouse intestine and colonization at the bovine terminal rectal mucosa
Escherichia coli O157:H7 causes hemorrhagic colitis and the life-threatening hemolytic-uremic syndrome in humans and transiently colonizes healthy cattle at the terminal rectal mucosa. To investigate the role of the O antigen in persistence and colonization in the animal host, we generated an E. coli O157:H7 mutant defective in the synthesis of the lipopolysaccharide side chain (O antigen) by ...
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The Effect of Probiotics for the Gut Health
There are trillions of microbes inhabiting the human intestine. These microbes gradually reach a balance of types and numbers during the process of reproduction, and this balance is closely related to the body's normal metabolism. Once the structure of the intestinal flora becomes imbalanced, various metabolic diseases will follow. The probiotics multiply in large quantities in the intestine, ...
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Applications of Diamine Oxidase
Diamine oxidase (DAO) is an intracellular enzyme that catalyzes diamine in mucosal or ciliated epithelial cells of the mammalian small intestine. It protects the intestinal mucosa by regulating intracellular ion homeostasis, influencing conduction pathways, and promoting cellular repair. Serum DAO is elevated in small intestinal mucosal barrier failure or in intestinal mucosal cell necrosis; ...
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Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review
Abstract Aerosol generating procedures (AGPs) may expose health care workers (HCWs) to pathogens causing acute respiratory infections (ARIs), but the risk of transmission of ARIs from AGPs is not fully known. We sought to determine the clinical evidence for the risk of transmission of ARIs to HCWs caring for patients undergoing AGPs compared with the risk of transmission to HCWs caring for ...
By Inspir Labs
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A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of ...
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World Rare Disease Day
On February 29 (or the last day of February) we celebrate World Rare Disease Day to raise awareness about these diseases, aiming to improve access to diagnosis, treatment and medical care. What are these diseases? Rare diseases are those that occur infrequently in the general population. In Argentina, “rare diseases” are those whose prevalence in the general population is equal to ...
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Human Microbiome Research Promotes Progress of Precision Medicine
A large part of bacterial, archaeal, viral, and fungal microbial taxa consists of the human microbiome. While many of these microorganisms are commensal, some are harmful to humans and many are symbiotic. Our livelihoods are strongly intertwined with the microbes we allocate our bodies with, regardless of whether their appearance is advantageous, insignificant, or harmful. Over the past few ...
By CD Genomics
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A Quick Guide to Proteolytic Enzymes
Protease formulations are without a doubt one of the most fully functional dietary supplements in terms of providing significant health benefits. Clinical studies have documented numerous effective benefits and support for people facing a variety of health challenges, including: a) Asthma b) Atherosclerosis c) Autoimmune disease d) Bronchitis e) Cancer f) ...
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Probiotics Have Many Benefits for the Human Body
Probiotics are active microorganisms that are beneficial to the human body. They promote nutrient absorption and maintain the health of the intestinal tract by regulating the balance of the intestinal flora. The human intestinal flora contains a large number of microorganisms, as many as hundreds of species. In addition to probiotics, there are other microorganisms, such as viruses, fungi, ...
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ELife: T Interferon Suppresses Inflammatory Diseases by Balancing the Microbiome
The maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls the response to acute microbial infection through the involvement of STAT1 transcription factors. However, the contribution of tonic levels of interferon to immune homeostasis in the absence of acute infection remains largely unexplored. The ...
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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HBOT for Complementary Therapy
If you’re considering HBOT, it’s important to understand the benefits and risks this therapy entails. The treatment should be discussed with a certified healthcare professional to develop a plan of action based on scientific evidence and tailored to your exact condition. Hyperbaric oxygen therapy can be used as complementary therapy to address several medical problems. The theory ...
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Saving Us from Ourselves: Harnessing the Power of CAR-T to Combat Autoimmunity
What is autoimmune disease? Autoimmune disease a condition in which the body’s immune system mistakenly attacks the body itself. Thus far, more than 80 different autoimmune diseases have been identified, with some of the most prevalent including rheumatoid arthritis, Crohn’s disease, type 1 diabetes, and multiple sclerosis [1]. Autoimmune disease is one of the top ten causes of ...
By Indee Labs
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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What does the environment have to do with diseases that affect the immune system?
The rise in recent decades of diseases such as inflammatory bowel disease and rheumatoid arthritis suggests that factors in the environment are contributing. In 1932, New York gastroenterologist Burrill Crohn described an unusual disease in 14 adults. The patients had bouts of abdominal pain, bloody diarrhea, and lesions and scars on the bowel wall. Doctors in other parts of North America and ...
By Ensia
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Recapitulating the Multifaceted Inflammatory Environment of the Intestine In Vitro
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. With access to a donor-derived cell biobank and the ability to recapitulate region-specific environments of the intestine, Altis Biosystems is working toward the development of an in vitro RepliGut® model to accurately recapitulate the complex intestinal ...
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Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis
Abstract Gut microbiota play an important role in immune responses and energy metabolism. In this study, we evaluated whether administration of Lactobacillus fermentum (L. fermentum) KBL375 isolated from healthy Korean feces improves the atopic dermatitis using the house dust mite (Dermatophagoides farinae)-induced atopic dermatitis (AD) mouse model. Administration of L. fermentum KBL375 ...
By KoBioLabs
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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...
By KoBioLabs
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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