cornea Articles
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Monte Carlo studies of the eyelid's influence on the absorbed dose in eye tissues
The aim of this work was to investigate the influence of the eyelid on the absorbed dose distribution in eye tissues. The study was performed using two versions of the female adult head phantom (FeH) connected to the GEANT4 Monte Carlo code: one has the eyes open and the second, closed. The calculations of organ dose, normalised to air KERMA free-in-air, were done for external exposures to photon ...
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Novel corneal implant in trials
The first in-human trials of a novel artificial implant designed to replace dysfunctional corneal endothelium have shown the device to be safe and well-tolerated, according to a study presented at the 25th ESCRS Winter Meeting online.“The initial results of the EndoArt (EyeYon Medical) are very promising indeed,” said Ruth Lapid-Gortzak MD, PhD, Amsterdam University Medical Centre in ...
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Implantation of an Artificial Endothelial Layer for Treatment of Chronic Corneal Edema
Abstract Purpose: The purpose of this study was to describe a novel device that may serve as an alternative to Descemet membrane endothelial keratoplasty (DMEK) for the treatment of chronic corneal edema. Methods: The EndoArt (EyeYon Medical, Israel) is a flexible, 50-μm thin artificial endothelial layer that matches the cornea’s posterior curvature and functions as a fluid barrier ...
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Contact Lens Permeation Testing from Systech Illinois
A contact lens design using a particular material will require the measurement of Oxygen Permeation. Materials with higher permeation rates together with thinner lenses will perform better, providing greater comfort during use. However, simply choosing the material with the highest permeation rate and making the lens thin is not an easy option. The lens shape and thickness varies with the ...
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Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated vaccine against herpes simplex virus type 1 (HSV-1), a widespread human pathogen that can cause ...
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Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1 (F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
Abstract Herpes simplex virus type-1 (HSV-1) can cause severe ocular infection and blindness. We have previously shown that the HSV-1 VC2 vaccine strain is protective in mice and guinea pigs against genital herpes infection following vaginal challenge with HSV-1 or HSV-2. In this study, we evaluated the efficacy of VC2 intramuscular vaccination in mice against herpetic keratitis following ocular ...
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Breakthrough Device Designation Received From the FDA for EndoArt
NESS ZIONA, Israel, Feb. 5, 2020 /PRNewswire/ -- EyeYon Medical (https://eye-yon.com/) is a start-up company developing a variety of ophthalmic products for vision-threatening conditions. EyeYon's new product, now on an accelerated path as a Breakthrough Device, is an Artificial Endothelial Layer - EndoArt® - a polymer film implant, attached to the posterior corneal surface, to treat chronic ...
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19C27
What is 19C27? Description LZQ is an OEM factory for all kinds of medical tools, such as Profile Drill P144, Dental Milling Bur/ Zirconia Bur P245, High Precision Fittings P76, Abutment/Transfer P25, ect. We can produce a whole kit of tools for customers' surgical cases. Product Details A complete line of Ophthalmic Surgical Knives includes Stab Knife, Slit Knife and Clear Cornea Knife, ...
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Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study
Abstract Introduction. To compare the safety and efficacy of the Therapeutic Hyper-CL™ lens versus a standard bandage contact lens (PureVision B&L) for chronic corneal edema. Methods. Prospective, multicenter, randomized, crossover study. Chronic corneal edema patients were randomized to one of two arms. The first arm was fitted with the Therapeutic Hyper-CL™ lens while the ...
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What Is Collagen?
Collagen is a family of proteins. At least 30 kinds of genes encoding collagen chains have been found, which can form more than 16 kinds of collagen molecules. According to its structure, it can be divided into fibrous collagen, basement membrane collagen, microfibrillar collagen, anchored collagen, hexagonal reticular collagen, non-fibrous collagen, transmembrane collagen, etc. According to ...
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How Much Do You Know about Glycosaminoglycans?
Glycosaminoglycan (GAG) is a general term for the glycan part of proteoglycan macromolecules. Glycosaminoglycans are large linear polysaccharides composed of repeating disaccharide units, and their main configuration contains amino sugars and uronic acids (glucuronic acid and/or iduronic acid). Glycosaminoglycans can be divided into chondroitin sulfate, dermatan sulfate, keratan sulfate, ...
By CD BioGlyco.
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Exploring the Potential Applications of Fluorescent Microspheres
Microspheres are small spherical entities formed by dispersing or adsorbing drugs in a polymer matrix. The particle size is typically between 1 μm and 250 μm, and the largest can reach more than 800 μm. Microsphere technology is at the intersection of cutting-edge disciplines such as materials science, polymer technology, medical technology, and microelectronics. Once injected into the ...
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Therapeutic contact lens for Fuchs endothelial corneal dystrophy: Monitoring with Scheimpflug tomography - Case Study
Abstract Purpose This case report demonstrates the effectiveness of a combined unique soft contact lens design and hypertonic saline at reducing corneal edema symptoms. In addition, this case shows that using tomographic data is invaluable for detecting and monitoring of these presentations. ...
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A single contact lens could give your entire life a head-up display
Mojo Vision's smart contacts put text in my eye and let me see in the dark. The company is aiming for even more than that. There aren't many meetings in Las Vegas during CES that still make my jaw drop. The few I can think of mostly involved Oculus. I had no idea what a company I've never met with before, called Mojo Vision, was going to show me. I knew they made very, very small displays. I ...
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Aramis Biosciences Announces First Patient Dosed in Phase 2 Clinical Trial Evaluating A197 for the Treatment of Dry Eye Disease
Aramis Biosciences announced that the first patient has been dosed in its phase 2 proof of concept clinical trial evaluating A197, a novel, first-in-class, topical immunomodulatory agent for the treatment of dry eye disease. “This is an important milestone for Aramis Biosciences and a hopeful moment for dry eye patients given the suboptimal efficacy and tolerability limitations commonly ...
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CD Genomics Perspective: RNA Sequencing, A Powerful Method for Studying Various Diseases
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
By CD Genomics
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RVx201 Herpes Vaccine
RVx201 Herpes Vaccine Description 2022 RVx201 is a first-in-human herpes simplex virus type 2 (HSV-2) live-attenuated therapeutic vaccine modified to be interferon sensitive that destroys the ability of the virus to inhibit immune responses. Produced by Rational Vaccines, Inc., the technology is based on the pioneering research of the late Dr. William Halford, who dedicated over 25 years to ...
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