coronary artery Articles
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How Fluoropolymers are Being Used in Cardiac Procedures
Your three main coronary arteries are responsible for bringing blood to the heart. When they start to become blocked, it can weaken the heart and eventually lead to a heart attack if the blockage isn't addressed and there isn't enough blood supply to the heart. On the left side of the heart, there are two coronary arteries responsible for providing rich blood supply to the heart to ensure it ...
By Fluorostore
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Rationale, Design, and Methodological Aspects of the BUDAPEST-GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions)
Abstract The heritability of coronary atherosclerotic plaque burden, coronary geometry, and phenotypes associated with increased cardiometabolic risk are largely unknown. The primary aim of the Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions (BUDAPEST-GLOBAL) study is to evaluate the influence of genetic and environmental factors on the ...
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Elevated Preoperative Galectin-3 Is Associated With Acute Kidney Injury After Cardiac Surgery
Annotations Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft surgery and/or valve. Patients in the highest third of Gal-3 levels had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the lowest third. Elevated preoperative Gal-3 levels significantly ...
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A Contemporary Review of ST-Elevation Myocardial Infarction: Pathophysiology, treatment options and hot topics
Pathophysiology, treatment options and hot topics Improvements In Stemi Treatment The immediate and long-term prognosis of patients experiencing an ST segment elevation myocardial infarction (STEMI) has changed dramatically since the introduction of coronary reperfusion therapies during primary percutaneous coronary intervention (pPCI). The evolution of these therapies accelerated with the ...
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Exercising Coronary Artery Disease patient - Case study
A cyclo-ergometer exercise test was performed on this 57-year old male patient. He is a smoker with a family background of CAD. He is suffering from left bundle branch block making ST-segment analysis impossible. The patient has achieved 78 % of max. heart rate at 120 watts. Moderate paleness and dyspnoea have been observed at the end of the 120 watts step. However, after a normal initial ...
By PhysioFlow
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Physiology and Pathology of Coronary Microcirculation
The heart is a unique organ in many respects since its activity is mandatory to sustain life. The heart’s circulatory system and coronary flow regulation are highly adapted to the vital role of the heart in sustaining life and to everyday physiological challenges. Understanding coronary physiology is key for treating patients with ischemic heart disease in general, and ...
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Noninvasive, Transthoracic, Low-Frequency Ultrasound Augments Thrombolysis in a Canine Model of Acute Myocardial Infarction
Background - Limitations of coronary thrombolysis include the time to reperfusion, patency rate, and bleeding. We evaluated the use of noninvasive transcutaneous ultrasound to augment coronary thrombolysis. Methods and Results - In 24 dogs, a thrombotic occlusion of the left anterior descending coronary artery was induced and documented by 12-lead ECG and coronary angiography. After $60 minutes ...
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EluNIR DES in a Challenging Case - Case Study
Background: This paper describes a challenging case of implantation of the EluNIR™ Ridaforolimus eluting elastomeric stent (Medinol Ltd.). This complex case involved a patient with a flow-limiting lesion in a native coronary artery post bypass surgery. The new EluNIR stent system includes a stent with a low metal footprint that comprises struts of variable width: ultra-narrow struts ...
By Medinol
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EluNIR First-in-Patient Implantation- Case Study
Background This paper outlines the first in-patient implantation of the EluNIR™ ridaforolimus eluting elastomeric stent (Medinol Ltd.). This complex case involved a patient with a flow-limiting lesion in a native coronary artery post bypass surgery. The new EluNIR stent system includes a stent with a low metal footprint which comprises struts of variable width: ultra-narrow struts having ...
By Medinol
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MRE associated with increased risk of cardiovascular disease in patients with NAFLD - Case study
A new study was published in March of 2021 demonstrating that elevated liver stiffness, as measured by magnetic resonance elastography (MRE), is associated with higher rates of cardiovascular disease in patients with non-alcoholic fatty liver disease (NAFLD). As clinical researchers, regulators and pharmaceutical partners pursue noninvasive biomarkers to replace liver biopsy, links to adverse ...
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ABILITY Diabetes Global enrolls thousandth patient: A Cardinal Milestone Achieved
ABILITY Diabetes Global (Randomized Comparison of Abluminus DES+ Sirolimus-Eluting Stents versus Everolimus-Eluting Stents in Coronary Artery Disease Patients with Diabetes Mellitus Global) started off with the index patient enrolment on 11th June 2020 in Italy (at the peak of the 1st wave of COVID-19 pandemic) by P.I. Prof. Antonio Colombo and the pace of enrolment since then has been steady and ...
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Chocolate PTCA Balloon Catheter for pre-dilatation of an occluded right coronary artery - Case Study
Incomplete stent expansion and malapposed stent struts are a predictor of subacute and late stent thrombosis. Appropriate lesion preparation prior to stent implantation is necessary to assure complete stent expansion and stent strut apposition. This is of particular importance in challenging lesions, in particular those with calcific plaque. The goal of the pre-dilatation is to obtain optimal ...
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What’s the difference between a heart attack, cardiac arrest and heart failure?
While heart attack, cardiac arrest and heart failure can sometimes be related, they’re actually three very different types of cardiac emergencies. Cardiac arrest, heart attack and heart failure — three terms that are familiar to most people, but often get confused with one another. While there can be some overlap between them in terms of cause and effect, they are actually three ...
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CD Genomics Perspective: RNA Sequencing, A Powerful Method for Studying Various Diseases
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
By CD Genomics
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The first CRISPR gene editing of vascular endothelium was made possible thanks to nanoparticles
The vascular endothelium is a single layer of endothelial cells that lines the surface of the vascular lumen, and it plays an important role in maintaining vascular homeostasis and tissue fluid balance. Many disorders, such as coronary artery disease, stroke, bronchopulmonary dysplasia, and pulmonary hypertension, are caused by endothelial dysfunction. Genome editing in endothelial cells can also ...
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Chronic Total Occlusion – Left Anterior Descending Proximal to Mid Lesion - Case study
Overview Dr. Craig Rosen used the Teleport® Microcatheter and several Sapphire® II PRO and Sapphire® NC Plus PTCA Balloons to perform a proximal to mid left anterior descending coronary artery (LAD) revascularization of a chronic total occlusion using stents. Patient History A 60-year-old Caucasian male patient with a BMI of 29, so overweight but not obese, presented ...
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Dental Problems Linked To Heart Disease and Diabetes
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. Every day new research is making the link stronger. Periodontal infection is the advanced stages of gum disease that causes bone loss. The bone loss is irreversible. Gingivitis is the early stage of gum disease and with early ...
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Autotransfusion device maker ships units to Ukraine
The developer of an autotransfusion device for collecting and cleaning a patient’s lost blood is sending hundreds of units to Ukraine as casualties climb from the Russian invasion. Baltimore-based Sisu Global Health has already sent 1,005 of its Hemafuse devices to hospitals in Kyiv and is planning a third shipment of 500 more any day now, co-founder and President Gillian Henker said. ...
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What is heart failure with preserved ejection fraction (HFpEF)?
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
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Cellular and molecular differences between HFpEF and HFrEF
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
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